THE POTENTIAL APPLICATIONS OF PLANT-BASED ANTI-CANCER COMPOUNDS AND THEIR CHEMICAL DERIVATIVES
AbstractCancer has evolved as a detrimental disorder alongside cardiovascular diseases. Plant-derived natural products have been the most successful source of potential anti-cancer drugs and for the isolation and characterization of novel compounds. Till now, only about 10% of the world’s biodiversity has been assessed for biological activity and numerous useful natural lead compounds are expected to be discovered in the near future. The exploration for anti-cancer agents from plant sources commenced in 1950s with the discovery of alkaloids; vinblastine and vincristine from Catharanthus roseus and the segregation of the cytotoxic podophyllotoxins from Podophyllum peltatum. Subsequently, paclitaxel or taxol was isolated from Taxus brevifolia bark and camptothecin was isolated from Camptotheca acuminata. Likewise, homoharringtonine, elliptinium, combretastatin A-4 betulinic acid, pervilleine-A, silvesterol, schischkinnin, and montamine are some of the other effective plant-originated anti-cancer compounds. With the developments in structural chemistry, a range of synthetic and semisynthetic lead compounds were designed and developed in laboratories. For instance, the semisynthetic analogues of vinca alkaloids are vinorelbine and vindesine, which are used either alone or in combination to combat several cancer types. Similarly, docetaxel, favopiridol, and roscovitine are some other plant-derived synthetic compounds from computational and combinatorial chemistry. In general, natural drugs are very safe, effective, and do not cause associated side effects when compared to synthetic compounds and hence, most preferred to combat cancers. Here we have summarized the applicability of plant-derived natural and their synthetic compounds considering the current practices and future perspectives in cancer therapies.
Article Information
1
4794-4804
761 KB
777
English
IJPSR
A. Shirolkar, S. Chougule, A. Ranade, A. Pawase, S. Gaidhani and S. Pawar *
Department of Pharmacology, National Research Institute of Basic Ayurvedic Sciences (NRIBAS), Kothrud, Pune, Maharashtra, India.
sd_pawar@yahoo.com
22 March 2022
18 August 2022
13 September 2022
10.13040/IJPSR.0975-8232.13(12).4794-04
01 December 2022