FORMULATION AND EVALUATION OF NATURAL PALM OIL BASED VANISHING CREAM

In present work, a new vanishing cream using a natural base from palm oil and palm kernel oil and standard vanishing cream using stearic acid were prepared. The creams were o/w emulsions containing suitable combination of oil phase and aqueous phase along with preservatives. Both creams were white, non-greasy and smooth on application. They were subjected to various parameters such as; pH, viscosity, spreadability and tube extrudability. Stability studies of the prepared creams were  determined at different temperatures for a period of 3 months as per ICH guidelines and the results revealed that both  formulations  were with good stability except the standard vanishing cream which was slightly hardened at 5^oC. The pH was found to be 6.7 and 6.98, and spreadability was found to be 11.30g. cm/sec and 13.33g.cm/sec for natural base and stearic acid based creams respectively. The tube extrudability was found to be good and fair for natural base and stearic acid based cream respectively. Furthermore, the formulations were studied for primary skin irritation test on rabbits and observed for skin rashes, inflammation, itching or redness on applied portions. Results revealed no adverse skin reactions with all the formulations. It was observed that vanishing cream containing natural base was pleasant, effective, easily washable and completely safe for human use. In contrast with ointments, which are greasy and messy in nature and may cause staining of clothes, the prepared Natural palm oil based vanishing cream was pleasant, easily washable thereby increasing patient compliance