XANTHAN GUM BASED ONCE A DAY MATRIX TABLET OF CEFIXIME TRIHYDRATE: DEVELOPMENT AND EVALUATION
AbstractThe present study was an attempt to investigate the feasibility of the matrix based sustained release unit dosage formulation of cefixime trihydrate. Matrix tablets were prepared by using xanthan gum along with the other polymer combinations (Guar gum, sodium alginate and hydroxypropylmethyl cellulose). Effect of different formulation variables like polymer concentration, ratio of polymer combination and compression force was evaluated. The Fourier transform infrared spectroscopy,differential scanning calorimeter and X ray diffraction analysis were also carried out to evaluate physico-chemical compatibility between drug and excipients. In vitro release results suggested a 24 h controlled drug release from the prepared tablet of cefixime trihydrate. Swelling and erosion studies were performed to verify the release mechanisms involved in the formulation. In vitro antimicrobial study was also performed to check the synergistic efficacy of CFT with excipients. The formulations were found to be stable up to 3 months of stability testing at 40ºC/75% RH
Article Information
13
3390-3399
687KB
1308
English
IJPSR
Nagendra Kumar , Rahul Tripathi , Gopal Nath and Brahmeshwar Mishra*
Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi – 221005, Uttar Pradesh, India
bmishrabhu@rediffmail.com
20 April, 2013
25 June, 2013
16 August, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3390-99
01 September, 2013
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