ANTI-NEOPLASTIC TRANSDERMAL PATCH: A NOVEL APPROACH IN BREAST CANCER THERAPY
AbstractBackground: In the present investigation Antineoplastic loaded transdermal patch was formulated using Liposomes, eudragit-RL, hydroxypropyl methyl cellulose K-50, and ethyl cellulose. Materials and Methods: Liposomes were formulated by solvent evaporation method using poly (sebacic acid-co-ricinoleic acid) in varying ratios and evaluated for particle size, drug loading, entrapment efficiency, transmission electron microscopy, differential scanning calorimetry and X-ray diffraction. Formulated tamoxifen-loaded liposomes were finally incorporated into transdermal patch and evaluated for thickness drug content, moisture content, moisture uptake, folding endurance, tensile strength diffusion coefficient, permeability coefficient, in-vitro permeation, and skin irritation. Optimized transdermal patches were tested for its pharmacokinetic and pharmacodynamics parameters. Results: Formulated transdermal patches showed improved bioavailability of tamoxifen when compared to its oral route. Conclusion: Tamoxifen-loaded liposomal transdermal patches could serve as a better alternative to existing marketed formulation in terms of bioavailability.
Article Information
44
5190-5199
1075 KB
659
English
IJPSR
Chandra Shekhar Sharma *, Subas Chandra Dinda and Anurag Verma
Department of Pharmaceutics, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
sharma.chandrashekhar16@gmail.com
22 August 2022
17 October 2022
19 November 2022
10.13040/IJPSR.0975-8232.13(12).5190-99
01 December 2022
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