SYNTHESIS AND BIOLOGICAL ASSESMENT OF QUINAZOLONE BASED AMIDE LINKAGE CONTAINING THIAZOLIDINONE AND THEIR DERIVATIVES
AbstractA number of substituted quinazolones are well known for their pharmacological activities like anti-inflammatory, antibacterial and analgesic etc. The present work deals with synthesis of quinazolone based thiazolidinone in order to enhance the biological properties. A Series of (2-(substituted phenyl)-4-oxothiazolidin-3-yl) -4- (4-oxo-2-phenyl quinazolin-3(4H)-yl) benzamide (6a-6h) were synthesized in good yield. The structures of the compounds obtained have been established on the basis of Spectral (IR, 1H NMR, 13C NMR and Mass) data. The present study also involves in vivo anti- inflammatory activity and in vitro antibacterial activity against few strains (gram positive and gram negative) of bacteria of synthesized compounds. Derivatives 6a, 6e and 6g exhibit promising anti-inflammatory and antibacterial activity with reference to standard drug Indomethacin and Ampicillin respectively
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