MICHELIA CHAMPACA LEAF EXTRACTS EXHIBIT HYPOGLYCEMIC EFFECT AND HYPOLIPIDEMIC ACTIVITY IN STREPTOZOTOCIN-NICOTINAMIDE-INDUCED DIABETIC RATS
AbstractA metabolic disease called diabetes mellitus in which blood glucose levels are abnormally high. It could be due to tissue glucose intolerance and impaired insulin production. In a Type II diabetes model generated by Streptozotocin and nicotinamide, the antidiabetic potential of ethanolic and aqueous leaf extracts of Michelia champaca (Magnoliaceae) was compared to a control group of diabetes. The anti-diabetic activity was tested on Wistar rats. The effective antihyperglycemic ethanolic and aqueous leaf extracts were tested at two doses of 250 mgkg-1 b.w. and 500 mgkg-1 b.w. for 21 days. Compared to the diabetic control group, the ethanolic extract at a dose of 500 mgkg-1 b.w. exhibits a highly significant (p<0.001) reduction in fasting blood glucose levels. After the trial, the blood sample was drawn from all animals for biochemical analysis. In extract-treated diabetic rats, the serum lipid profile was calculated. The biochemical investigation, serum cholesterol, serum triglyceride, high-density lipoprotein, and low-density lipoprotein support the ethanolic extract’s anti-diabetic effectiveness.
Article Information
45
5200-5206
763 KB
475
English
IJPSR
Jyoti Nanda *, Munesh Mani , Shanti Bhushan Mishra and Neeraj Verma
School of Pharmaceutical Sciences, CSJM University, Kanpur, Uttar Pradesh, India.
jyotinanda954@gmail.com
14 September 2022
11 November 2022
15 November 2022
10.13040/IJPSR.0975-8232.13(12).5200-06
01 December 2022
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