DIURETIC ACTIVITY OF ETHANOLIC EXTRACT OF IMPERATA CYLINDRICAL (L.) P. BEAUV. (POACEAE) LEAVES ON RAT
AbstractThis work aimed to evaluate the diuretic activity of Imperata cylindrica (Poaceae) leaves on rat. The extract was administered orally at doses 100, 200 and 400 mg/kg. The 24h urine volume and its pH were measured, natriuresis and kaliuresis were dosed. The results show that I. cylindrica increases diuresis, natriuresis and kaliuresis, but doesn’t affect urine pH. Diuresis of 24 h urine increases from 3.23 ± 0.32 ml in control group, to 5.33 ± 0.38, 6.83 ± 1.23 and 75 ± 1.32, respectively, in rats treated with the extract (P<0.05). Natriuresis increases from 1.21 ± 0.52 mEq/L to 2.38 ± 0.20, 3.15 ± 0.11 and 5.46 ± 0.72 mEq/L (P<0.05). Kaliuresis increases from 0.51 ± 0.71 mEq/L to 0.73 ± 0.65, 1.21 ± 0.51 and 1.75 ± 0.36 mEq/L (P < 0.05). The pH does not change, it is 8.52 ± 1.59 in control group and 8.51 ± 1.59, 8.47 ± 1.57 and 8.49 ± 1.58, in groups treated with the extract (N.S). These results show that Imperata cylindrica is a mild diuretic at the doses used, which might act at the ascending limb of Henle Loop or the diluting zone.
Article Information
18
719-724
9116 KB
610
English
IJPSR
S. G. Andriamalala *, T. T. Andriamampianina, R. Razanadrabenafindra, F. Randimbivololona, N. Quansah and P. Randrianavony
Department of Pharmacology, Faculty of Sciences, University of Antananarivo, Madagascar.
andriamalalas@yahoo.fr
15 June 2022
29 August 2022
19 November 2022
10.13040/IJPSR.0975-8232.14(2).719-24
01 February 2023
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