ROLE OF AQUEOUS EXTRACT OF JUSSIAEA REPENS ON CELLULAR OXIDATIVE STRESS AND METABOLIC STATUS IN DIABETIC RATS INDUCED BY STZ.

This work aimed to explore how crude aqueous extract of Jussiaea repens affected oxidative stress and metabolic status in streptozotocin (STZ) induced diabetic male rats. The diabetic rats were gavaged with aqueous extract of Jussiaea repens (50 mg/100 g body weight/day for 32 daysconsicutively) after an induction of STZ (8 mg/100g body weight, i.p.). Fasting blood glucose, insulin, serum LDH, total GSH, MDA, G-6-PDH, amylase, lipase, catalase and superoxide dismutase were measured. The hepatic levels of hexokinase, PFK, G-6-Pase, F-1,6-BPase and glycogen were also measured. The aqueous extract of Jussiaea repens decreased blood glucose level in diabetic control group. The extract supplemented group also demonstrated a notable improvement in blood insulin levels, SOD, GSH and G-6-PDH level in comparison to diabetic group. In diabetic group, the LDH and MDA levels were significantly higher than non-diabetic control rats and were significantly recovered in extract supplemented group. But catalase level showed no significant change. The liver glycogen, hexokinase and PFK were lower in the diabetic group, whereas G-6-Pase and F-1,6-BPase were higher, showing statistical recovery in the extract-treated group. Serum amylase and lipase followed the pattern of recovery like G-6-Pase and F-1,6-BPase. These findings suggested that aqueous extract of Jussiaea repens could regulate diabetes mellitus and oxidative stress in diabetics. This work will aid in the development of cheap herbal medicine for the amelioration of diabetes mellitus in future.