HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF ACALYPHA COMMUNIS MULL. ARG. AGAINST INTOXICATION OF THIOACETAMIDE AND RIFAMPICIN-INDUCED RATS
AbstractBackground: The present study aimed to evaluate the hepatoprotective activity of aqueous extract of Acalypha communis in Wistar rats. Methods: The hepatoprotective activity was studied by Thioacetamide (TAA) (100 mg/kg b.wt.i.p) and Rifampicin (RMP) (100 mg/kg, po) induced models. Acute toxicity studies and preliminary phytochemical screening were also studied to evaluate the toxicity. Results: No toxicity profile was observed in rats after oral administration of the ethanolic leaf extract at 5mg/kg body weight. The different doses of 200 mg/kg and 400 mg/kg were administered with the extract of Acalypha communis; there was significant (P < 0.001) reduction in Biochemical parameters with respect to control. Phytochemical screening of the plant extract revealed the presence of tannins, alkaloids, flavonoids, saponins, and terpenoids. Conclusion: It can be concluded that the hepatoprotective activity elucidated by Acalypha communis could be mainly due to the presence of a high-value class of compound like the phenolic group as the major content in the plant.
Article Information
34
845-851
1195 KB
416
English
IJPSR
T. Muthuramu *, Gopinath, Thressiamma Sebastin, Neethu Murali and K. U. Athira
Department of Pharmacology and Toxicology, KTN College of Pharmacy, Palakkad, Kerala, India.
muthucology@gmail.com
06 June 2022
24 July 2022
04 August 2022
10.13040/IJPSR.0975-8232.14(2).845-51
01 February 2023
Download