THIN LAYER CHROMATOGRAPHIC SEPARATION OF BENZODIAZEPINES BY SEVEN DIFFERENT SOLVENT SYSTEMS
AbstractBenzodiazepines are psychoactive drugs used to treat anxiety, epilepsy, convulsions, and psychiatric and sleeping disorders. These medicinal compounds possess considerable importance in forensic toxicology due to their tranquilizing, hypnotic, and anticonvulsant properties. Thus, identifying and separating these compounds found significance in pharmaceuticals. The high-performance liquid chromatography (HPLC) technique is employed to separate benzodiazepines. The present research article aims to provide a more straightforward and efficient method for separating benzodiazepines. The thin layer chromatography (TLC) technique follows to separate benzodiazepines containing silica gel 60 F254 as a stationary phase. The seven different mobile phases for the separation of benzodiazepines are employed. The combination of Acetone: Toluene: Ethanol: Ammonia (45:45:7:3) is the best solvent system for separating benzodiazepines among the seven chosen solvent systems.
Article Information
41
1442-1451
1737 KB
620
English
IJPSR
Anjali Sharma, Geeta Wadhvani, Sushil Kumar Sharma and Shobhana Sharma *
Department of Chemistry, S. S. Jain Subodh P. G. College, Jaipur, Rajasthan, India.
shobhna.sharma51@gmail.com
23 July 2022
03 November 2022
20 November 2022
10.13040/IJPSR.0975-8232.14(3).1442-51
01 March 2023
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