EFFECT OF QUERCETIN ON HYPOXIA-REGULATED METASTATIC MARKERS IN AGGRESSIVE PANCREATIC CANCER CELLS UNDER HYPOXIC CONDITIONS
AbstractTumor hypoxia is an important pathological condition that influences several signaling cascades in malignant cells, eventually leading to therapy resistance. Several natural bioflavonoids hold promise as anti-cancer agents. However, the effect of Quercetin on hypoxic pancreatic cancer cells is unknown. We analyze the effect of Quercetin on expression levels of metastatic markers HIF1α and E-cadherin under hypoxic conditions. Quercetin treatment was significantly correlated with reduced HIF1α expression levels and elevated E-cadherin levels. Our results suggest that Quercetin may alter E-cadherin levels by regulating HIF1α expression. Quercetin may inhibit pancreatic cancer cell metastasis by regulating metastasis genes in a hypoxic microenvironment and has pharmacological potential in aggressive pancreatic cancer treatment.
Article Information
48
1507-1510
547 KB
308
English
IJPSR
Phani Bhushan Meka, Hiba Ahmed, Hajera Unissa, Huda Tahera, Mohammad Ahmed Waheed, Maryam Sadiq, Sumayya Afreen and Nazima Begum *
Vimta Labs Ltd, Hyderabad, Telangana, India.
Naazbio123@gmail.com
19 July 2022
26 August 2022
18 September 2022
10.13040/IJPSR.0975-8232.14(3).1507-10
01 March 2023
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