EFFECT OF ANTINEOPLASTIC LOADED TRANSDERMAL PATCH IN DMBA-INDUCED BREAST CANCER
AbstractBackground: The current study assessed the effect of an Antineoplastic-loaded transdermal patch in Dimethyl-benzanthracene (DMBA)-induced breast cancer. Materials and Methods: Different formulations composed of various concentrations of tamoxifen citrate, poly (SA: RA), glucose, and mannitol were formulated and evaluated in DMBA-induced breast cancer in female albino Wistar rats. Multiple parameters were evaluated, such as body weight, hemoglobin content, red blood cell, white blood cell, SGPT, and SGOT. Results: Treatment with formulations showed a decrease in body weight compared to disease. Equally, a considerable increase in hemoglobin was observed in the formulation-treated group over the disease grouping. Likewise, there is a decrease in SGPT and SGOT in formulation compared to disease. Conclusion: The present study revealed a transdermal patch loaded with tamoxifen showed promising antitumor activity.
Article Information
51
1528-1533
777 KB
860
English
IJPSR
Chandra Shekhar Sharma *, Prashant Kumar and Anurag Verma
Department of Pharmaceutics, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
sharma.chandrashekhar16@gmail.com
02 September 2022
11 December 2022
14 February 2023
10.13040/IJPSR.0975-8232.14(3).1528-33
01 March 2023
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