SYNTHESIS, CHARACTERIZATION OF BENZOXAZOLE DERIVATIVES FOR IN-VITRO ANTI-TUBERCULAR AND ANTI-BACTERIAL ACTIVITY – A RESEARCH ARTICLE
AbstractDifferent-different modification of Benz-oxazole moiety gives various numbers of novel compounds which shows various biological activities. Some new derivatives (G7-G10) containing Benzoxazole moiety were prepared by the use of different methods and reagents. O- Phenylenediamine treated with Chloroacetic acid to form 2(chloro methyl) benzimidazole (compound B) and 4- methyl, 2- amino phenol with methyl alcohol and carbon di sulfide to form 2-thio, 5- methyl, benz-oxazole (compound G1). Further Compound B treated with (compound G1) to form [(benz-imidazole)-2-methyl thio]-5-methyl, benzoxazole (compound G2). Finally compound G2 treated with a substituted aldehyde to form benzoxazole derivatives (G7-G10). Compound spectral analysis was done by Infrared spectroscopy (IR), 1H-Nuclear magnetic resonance (1HNMR) & Liquid chromatography-mass spectroscopy (LCMS). The serial Dilution method (MIC test) was used for anti-bacterial activity, and Alamar blue assay test was used for Anti-tubercular activity. Compounds G8 and G9 showed potent anti-tubercular activity against M. Tuberculosis, and Compounds G7, G8 and G10 were showed good antimicrobial activity.
Article Information
26
1789-1794
746 KB
327
English
IJPSR
Bhupendra Chauhan *, Gaurav Kumar, Sanjay Singh and Manisha Negi
Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, Uttar Pradesh, India.
bhupendrapharma@gmail.com
03 August 2022
05 September 2022
21 October 2022
10.13040/IJPSR.0975-8232.14(4).1789-94
01 April 2023
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