FORMULATION AND EVALUATION OF TOPICAL ITRACONAZOLE NANOGEL

Itraconazole is a triazole antifungal category drug used for the treatment of local &Systemic fungal infections. Itraconazole is not recommended to neutropenic and other immune-compromised patients who have difficulty swallowing the oral capsule formulation, and it has many side effects. Commercially, Itraconazole topical gel preparation is not available in the market; thus, this formulation is made for better patient compliance, reduces the drug dose, and avoids side effects like liver damage and kidney damage avoiding first-pass metabolism. The gel was formulated by preparing nanocomposite with polymer inclusion complex by microwave-induced diffusion technique. Which ultimately results in enhancing the water solubility of nanocomposites. The resultant polymer-based nanocomposite retains the inherent properties nanoparticles, while providing higher stability, and this nanocomposite is incorporated into the gel base. Prepared nanogel Prepared nanogel is characterized by pH determination, Spreadability, Viscosity measurement, In-vitro diffusion, antifungal activity. Among the formulation, F₃ was selected as the best formulation having % CDR of 76.57 % & more Antifungal activity than the marketed formulation. The results indicated that nanocomposite-based nanogel is a promising approach for the transdermal delivery of Itraconazole.