CHEMISTRY OF HYALURONIC ACID AND ITS SIGNIFICANCE IN DRUG DELIVERY STRATEGIES: A REVIEW
AbstractHyaluronic acid is an important naturally occurring polysaccharide present in extracellular matrices. The network-forming, viscoelastic and the charge characteristics of hyaluronic acid are important to many biochemical functions of living tissues. Its involvement in many diseases such as cancer, arthritis and osteoporosis, and the fact that it has specific protein receptors present on the cell surfaces, has given new impetus in drug design and synthesis of hyaluronic acid-drug conjugates. As a general arrangement, the review will focus on structure and conformation of hyaluronic acid, its chemistry and chemical methodologies that have led to a number of important hyaluronic-drug conjugates
Article Information
2
3699-3710
498KB
1939
English
IJPSR
R. Khan*, B. Mahendhiran and V. Aroulmoji
Scientific Research Consultant, Rumsey, Old Bath Road, Sonning, Berkshire, RG4 6TA, England, UK
riazazami@gmail.com
15 April, 2013
11 September, 2013
26 September, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3699-10
01 October, 2013
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