IN-SILICO VALIDATION AND PHARMACOLOGICAL ACTIVITY OF POTENT ANTI VIRAL AND ANTI INFLAMMATORY ETHNO MEDICINAL PLANTS USED BY TRADITIONAL HERBALISTS WITHIN THORANGTLANG WILDLIFE SANCTUARY, MIZORAM, NORTH-EAST INDIA

Background: Our study aims to document the use of ethnomedicinal plants reported by herbalists in treating ailments that are becoming more prevalent. Using an ethnobotanical approach and in-silico studies, will advise further prevalence and give precedence to future pharmacological studies. Methods: The application of the plants was reported by 75 informants. From the 51 reported plants, 20 plants were frequently cited as having high potential anti viral and anti-inflammatory activity and were validated in in-silico approach. PASS was used for compound prediction, and AMT was calculated with the help of ADMET lab 2.0. Results: Out of the 20 plants validated in in-silico, the results of reported compounds revealed that Aeginetia indica could best act as an antiviral agent with Pa (0.939) and Pi (0.003), followed by Bacopa monnieri with Pa (0.880) and Pi (0.002) and Blumea balsamifera with Pa (0.743) and Pi (0.004). Subsequently, the plant which can act as the best anti-inflammatory ailment is Andrographis paniculata with Pa (0.845) and Pi (0.005), followed by Pisum sativum with Pa (0.749) and Pi (0.010) and Blumea balsamiferawith Pa (0.728) and Pi (0.013). Also, the plant which constitutes both potential is Blumea balsamifera. Conclusion: The pharmaceutical innovation could be useful to validate medicinal plants to treat a wide range of ailments, as well as to actively promote natural medicine and the discovery of novel medicines.