A COMPREHENSIVE REVIEW OF SYNTHESIS, DOCKING TARGETS AND PHARMACOLOGICAL ACTIVITIES OF PYRAZOLINE DERIVATIVES
AbstractPyrazolines, among the various 5-membered heterocyclic compound derivatives, have drawn attention towards it because of their various pharmacologic activities. They are nitrogenous heterocyclic compounds containing two nitrogens in the adjacent position, which possess considerable biological activity. The synthesis of pyrazolines was initiated after the pioneering work of Fischer and Knoevenagel in the late 19th century. Later, Claisen-Schmidt condensation, and Aldol-condensation, became the most popular methods for the preparation of pyrazolines nowadays. It has been an exciting area of pharmaceutical chemistry to research the biological evaluation of pyrazoline derivatives. The review provides different methods for the synthesis of pyrazolines by Claisen-Schmidt condensation, Aldol-condensation, 1,3-Dipolar Cycloaddition and its biological activities like anti-inflammatory, anti-tubercular, hypotensive, Cannabinoid CB1 Receptor Antagonist activity, anti-viral, etc. It also gives information regarding different possible docking targets and examples in figures. This review article will help explore novel pyrazoline analogues for challenging pathophysiological conditions.
Article Information
17
2784-2793
834 KB
455
English
IJPSR
Rincy Meriyam Varghese *, Christy K. Jose, Santhosh M. Mathews and Mincy Mathew
Department of Pharmaceutical Chemistry, Pushpagiri College of Pharmacy, Thiruvalla, Kerala, India.
rincymeriyam97@gmail.com
14 September 2022
25 March 2023
30 April 2023
10.13040/IJPSR.0975-8232.14(6).2784-93
01 June 2023
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