SYNTHESIS, CHARACTERIZATION, AND ANTIOXIDANT ACTIVITY OF NEW PYRAZOLES
AbstractPyrazole and its derivatives are pharmacologically active and are being used in various disorders and diseases with a few side effects. The wide distribution of pyrazole compounds in nature with fascinating pharmacological action is key in the application of this development of newer derivatives. The main structure has a great variety of compounds that have essential pharmaceutical and agrochemical activities in addition to biological activity like anti-inflammatory, antifungal, antitumor, antiviral, antibacterial, anti-tubercular, and antiphrastic. Protection against various substances that causes oxidative stress in the body is needed in the modernizing world in this direction intermediate obtained from the Vilsmeier Haack reaction (4) was treated with aromatic amines to obtain N-[3-(naphthalen-1-yl)-1-phenyl-1H-pyrazol-4-yl] methylene) derivatives (5a-5l). The in-vitro antioxidant activity of newly synthesized compounds was determined by the Nitric oxide scavenging method.
Article Information
30
2907-2913
571 KB
285
English
IJPSR
Monica Arora * and H. M. Rudresh
Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Bangalore, Karnataka, India.
monicaarora15@gmail.com
14 September 2022
08 November 2022
24 December 2022
10.13040/IJPSR.0975-8232.14(6).2907-13
01 June 2023
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