EXTRACTION ISOLATION CHARACTERIZATION AND PHARMACOLOGICAL SCREENING OF AEGLE MARMELOS FOR ANTIASTHMATIC ACTIVITY
AbstractAegle marmelos (L) Correa also known as Bale, belongs to family Rutaceae. The plant is used to treat several diseases like bronchitis, asthma, malarial, astringent, laxatives, digestive and febrifuge. Leaves are used as antipyretic, antimicrobial, antidiabetic, antihistaminic, anti-inflammatory, antioxidant, and hyperlipidaemic activity. The plant contains diterpenoids, triterpenoids, and phenolic compounds. The present investigation was carried out to isolate, purify, and characterize active constituents from the Aegle marmelos (L) Correa plant. Powdered material of the whole Aegle marmelos (L) Correa plant was taken to prepare extract using Soxhlet apparatus. Various phytochemical tests were performed for alkaloids, glycosides, phenolic, flavonoids, etc. TLC was done for the isolation of compounds. GC-MS, thin layer chromatography, and Nuclear magnetic resonance further characterized the isolated compounds. The anti-asthmatic was evaluated by using in-vitro models. The Petroleum ether extract of Aegle marmelos (L) Correa significantly inhibited histamine contraction and confirmed the significant anti-asthmatic activity.
Article Information
46
3070-3075
768 KB
295
English
IJPSR
Vaishnavi S. Kurade * and T. Narvekar Vandana
Dr. J. J. Magdum Pharmacy College, Jaysingpur, Kolhapur, Maharashtra, India.
vaishnavikurade32@gmail.com
16 October 2022
05 December 2022
30 April 2023
10.13040/IJPSR.0975-8232.14(6).3070-75
01 June 2023
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