EFFECT OF XYLIA DOLABRIFORMIS LEAVES EXTRACT ON HIGH FRUCTOSE DIET INDUCED C57BL/6J OB/OB DIABETIC MICE

The objective of the present study was to investigate anti-diabetic and nephroprotective and cardioprotective activity of Xylia dolabriformis leaves extract, using High Fructoseinduced diabetic C57BL/6Job/ob mice as model for clinical type-2 diabetic. At a regular interval of an experimental protocol blood glucose, urinary creatinine, total proteins, insulin resistance, total β-cell count, LDL, HDL,VLDL and organs to body weight ratio were studied. The histo-pathological study was carried out by High Fructoseinduced diabetic and anti-diabetic rats pancreas. Statistical analysis of the results shown that in High Fructoseinduced diabetic rats chloroform and alcohol extracts of Xylia dolabriformis leaves at 40, 80, 160 and 200 mg/kg doses. Xylia dolabriformis leaves extract improved renal creatinine clearance, decreased the LDL, VLDL, increased the HDL and reduce renal total protein loss demonstrating nephroprotective and cardioprotective properties. The organ to body weight ratio studies carried out on last day, shown pancreas and liver specific effects of Xylia dolabriformis leaves. These results were also supported by histo-pathological studies. We conclude from the present study that Xylia dolabriformis alcoholic extract and chloroform extract long-term treatment may be beneficial in the management of diabetes.