QUALITY STANDARDIZATION OF AYURVEDIC FORMULATIONS – SANSHAMANI VATI AND MAHALAXMIVILAS RASA

Purpose: Sanshamani Vati (SHV) is useful in all types of Jwara, and Mahalaxmivilas Rasa (MLVR) is the best drug in various cardiovascular and respiratory disorders. To maintain the enormous trust in Ayurveda, it’s necessary to ascertain the quality, efficacy & safety of Ayurvedic formulations on scientific lines using modern techniques. Present work attempts have been made to standardize the traditional Ayurvedic formulations – SHV and MLVR with modern techniques. Method: The formulations were standardized for physicochemical, Elemental and phytochemical screening. The XRD profiling was done for MLVR. Also the authentication of RM used in SHV was done using HPTLC. The validation of the methods for Elemental and phytochemical assays was performed as per ICH guidelines. Results: The Physico-chemical and phyto-chemical screening of Sanshamani Vati, and Mahalaxmivilas Rasa Tablets was done. The HPTLC profile confirms the presence of Berberine at Rf 0.25 ± 0.02 in SHV and Myristicin at Rf 0.50 ± 0.02 in MLVR. The elemental content of Gold (Au), Iron (Fe), Mercury (Hg) & Copper (Cu) in MLVR was estimated by ICP-OES. HPTLC Densitogram confirms the presence of authenticated Tinospora cordifolia RM in SHV. The XRD profile confirms the absence of free toxic metals – Hg & As. Conclusion: The present work will help understand therapeutic value concerning the quality parameters of the formulations. The standardization parameters presented in this research may serve as a standard reference to set the quality parameters for Sanshamani Vati and Mahalaxmivilas Rasa.