AN OVERVIEW OF AZOLE ANTIFUNGALS
AbstractFungal infections in critically ill or immunosuppressed patients were increasing in incidence in the human population over the last 1-2 decades. There were few advances in antifungal therapy and, until recently, there were few choices from which to select a treatment for systemic mycoses. However, in the past decade, there have been several developments in this area. Antifungal agents are sufficiently diverse in activity, toxicity, and drug interaction potential. Azoles are synthetic and semi-synthetic compounds. They have a broad spectrum of activity. Triazole antifungals are active to treat an array of fungal pathogens, whereas imidazoles are used almost exclusively in the treatment of superficial mycoses and vaginal candidiasis. Despite the advances, serious fungal infections remain difficult to treat, and resistance to the available drugs is emerging. Use of the currently available azoles in combination with other antifungal agents with different mechanisms of action is likely to provide enhanced efficacy.The present review aims to explore the pharmacology, pharmacokinetics, spectrum of activity, safety, toxicity and potential for drug–drug interactions of the azole antifungal agents
Article Information
2
4083-4089
340KB
1961
English
IJPSR
Pratibha Shivaji Gavarkar*, Rahul Shivaji Adnaik, and Shrinivas Krishna Mohite
Rajararambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli- 415404, Maharashtra, India
pratibhagavarkar@gmail.com
07 June, 2013
20 July, 2013
09 October, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4083-89
01 November, 2013
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