ANTIDIABETIC ACTIVITY OF METHANOLIC AERIAL EXTRACT OF EUPHORBIA MILII DES MOUL IN STREPTOZOTOCIN–NICOTINAMIDE INDUCED TYPE 2 DIABETIC RATS
AbstractIt is an ornamental shrub native to Madagascar and the Philippines, widely distributed in India. Euphorbia milii Des Moul is widely used in folk medicine to treat warts (South Brazil), cancer and hepatitis in (China). The present study seeks to evaluate the methanolic aerial extract of Euphorbia milii Des Moul (MAEEM) for its anti-diabetic effect against streptozotocin–nicotinamide induced type 2 diabetic model in Albino Wistar rats. Oral glucose tolerance test, Phytochemical screening and Acute toxicity study were carried out. Graded doses of MAEEM (100mg/kg, 200mg/kg and 400mg/kg) were administered to diabetic rats for 21 days. The activity was evaluated by using some biochemical parameters such as blood glucose levels, serum lipid profiles, liver profile markers (AST, ALP, ALT), and renal profile markers (serum creatinine, blood urea). Type-2 diabetes significantly altered these parameters, while oral administration of the MAEEM significantly ameliorated them.
Article Information
35
3978-3984
689 KB
266
English
IJPSR
Shivali Sagar *, Rajeev Sati and Monika Bisht
School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Dehradun, Uttarakhand, India.
shivalisagar007gmail.com
28 November 2022
05 February 2023
27 May 2023
10.13040/IJPSR.0975-8232.14(8).3978-84
01 August 2023
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