Volume 15 (2024) - Issue 11, November
Review Articles
MOLECULAR MECHANISMS OF FIBROBLAST GROWTH FACTOR IN HEPATO-CELLULAR CARCINOMA
Hepatocellular carcinoma (HCC) is a widespread and lethal cancer type that affects people worldwide. Growth factor signalling pathways are critical in non-alcoholic fatty acid liver disease (NAFLD) and HCC as they activate a cascade of events that disrupt normal liver function. Therefore, these pathways offer a promising therapeutic strategy for NAFLD associated HCC. Several studies have found tha...
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POTENTIAL NATURAL SKIN CANCER (MELANOMA) TREATMENTS USING FLAVONOIDS: BIOTHERAPEUTIC APPROACHES
There are a variety of treatment options for melanoma, but the high resistance of tumor cells to conventional therapies makes it necessary to develop new anticancer agents that will have decline toxic effects and greater effectiveness, thereby providing an incentive for the development of new treatments that can be used alone or in combination with other drugs. The flavonoids are phenolic phytocon...
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GLOBAL PERSPECTIVES ON MEDICAL DEVICE REGULATIONS: A COMPARATIVE STUDY OF US, CANADA, EUROPE, INDIA, AND JAPAN
This review paper compares medical device regulations across the United States (US), Canada, Europe, India, and Japan. It offers an understanding of the many regulatory frameworks that control the approval processes for medical devices, the Competent Authorities, the rules and regulations, the licensing or registration processes, the classification systems for devices, and the quality management/G...
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Research Articles
IN-VIVO TOXICOLOGICAL PROFILE OF THE AQUEOUS EXTRACT OF THE ROOTS OF SCHUMANNIOPHYTON MAGNIFICUM (K. SCHUM.) HARMS (RUBIACEAE) IN WISTAR RATS
Background: Also known as Gogologo, Schumanniophyton magnificum (K. Schum.) Harms is a medicinal plant used by the “Baka” Pygmies in the South region of Cameroon for the management of erectile dysfunction, but less information is known on its potential toxicity. Objective: This study aimed to assess the safety and toxicological potential of the aqueous extract of the plant's roots through acut...
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A COMPARATIVE STUDY OF THE ANTIBACTERIAL ACTIVITY OF URTICA DIOICA L. AND URTICA DIOICAL. VARIETY ANGUSTIFOLIA
Urtica dioica L. and Urtica dioica L. angustifolia are commercialized as the same plant under the name stinging nettles (Ortiga) but, to our knowledge, the antibacterial properties of the variety angustifolia are unknown. The antibacterial activity of Urtica dioica L., collected in the State of Mexico, was compared with that of Urtica dioica L. variety angustifolia, acquired in a market in Mexico ...
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BIOAVAILABILITY ENHANCEMENT AND CHARACTERIZATION OF POORLY WATER-SOLUBLE DRUG
Objectives: Lovastatin is an antilipidemic medication categorised as a statin, which exhibits limited absorption when taken orally owing to its low solubility and inconsistent dissolution rate. The primary objective of this research was to improve the drug's solubility and dissolving rate, as well as gain insight into its oral bioavailability. Materials and Methods: A precipitation-ultrasonication...
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FORMULATION AND IN-VITRO EVALUATION OF POLYETHYLENE GLYCOL BASED ORAL MUCOADHESIVE GELS OF TACROLIMUS MONOHYDRATE
Oral Lichen Planus (OLP) is a rare chronic autoimmune mucocutaneous inflammatory disease characterized by painful oral lessions. Immunosuppressive agent Tacrolimus monohydrate is one of the effective therapy options for OLP as it possesses benefits such as greater safety and efficacy at lower doses over currently employed topical corticosteroids. From amongst its topical dosage forms, mucoadhesive...
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A COMPARATIVE STUDY BETWEEN USE OF LOW DOSE BUPIVACAINE AND BUPIVACAINE PLUS FENTANYL IN SPINAL ANAESTHESIA IN TRANSURETHRAL RESECTION OF PROSTATE
Spinal anaesthesia is most frequently used for transurethral prostatectomy (TURP), because it permits early recognition of TURP syndrome. However, many elderly patients can have coexisting cardiac or pulmonary disease so, it is important to limit the distribution of spinal block in such patients. Aim and Objectives: To evaluate the efficacy and effect of addition of fentanyl 25 μg (0.5 ml) intrat...
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CHITOSAN NANOPARTICLES FROM PERSEA AMERICANA SEEDS: ANTIDIABETIC FORMULATIONS & BIOACTIVITY ASSESSMENT
Avocado (Persea americana) seeds are an excellent source of antioxidants, and phenolic compounds were used to create green synthesis nanoparticles that were then incorporated into formulations for solid herbal tablets. The process of ionic gelation is used to synthesize biopolymer chitosan nanoparticles. The characterization was done by UV and FTIR spectroscopy. FTIR spectroscopy showed that chito...
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AN UPDATED ANALYSIS OF ETIOLOGIES AND PROGNOSIS OF 30-DAY READMISSION IN HEART FAILURE
Background: The prevalence of Heart Failure (HF) is expected to rise over the next few decades, placing a significant strain on the healthcare system. Exact risk stratification in HF is still difficult, even though numerous prognostic markers of death and/or HF hospitalization have been found in HF patients; nonetheless, their practical usefulness is restricted. Aim and Objective: The current s...
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STUDIES ON THE METHANOL EXTRACT OF LEPIDAGATHIS FASCICULATA AND ITS FRACTIONS FOR THE TREATMENT OF DIABETES AND FOR IN-VITRO ENZYME INHIBITION
The present research focused to decide the premier dosage of methanol extract of Lepidagathis fasciculata whole plant extract and examining the α-amylase and α-glucosidase inhibitors of diabetic rats utilized to execute stronger command of hyperglycemia allowed for the blood glucose to be lowered in these animals. In streptozotocin-induced rats, the anti-hyperglycemic effects of oral administrat...
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PROFILE OF PEDIATRIC PATIENTS VISITING THE EMERGENCY DEPARTMENT AT A TERTIARY CARE TEACHING HOSPITAL IN SOUTH INDIA
Background: Understanding the dynamic profiling of emergency department (ED) visits, particularly among pediatric patients, is crucial for implementing targeted interventions to enhance outcomes and optimize triage systems for this vulnerable population. Aim and Objective: This study aimed to profile the demographics, clinical presentations, and treatments of pediatric patients admitted to the ED....
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MICROBIOLOGICAL OBSERVATION CONCERNING THE STABILITY PROFILE OF TRIPHALA CHURNA WITH REFERENCE TO BASELINE STUDY
Introduction: Triphala Churna a polyherbal Ayurvedic formulation – with significant therapeutic potential is used to treat a variety of oral ailments. To ensure product’s quality and effectiveness, it is essential to evaluate its microbiological stability. Materials and Methods: Triphala Churna was prepared using standard procedures and stored in various containers for ten months under differe...
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FORMULATION AND EVALUATION OF HERBAL LIPSTICK USING NATURAL COLOUR EXTRACT FROM AMARANTHUS GANGETICUS LINN LEAF
Cosmetics have been in high demand since ancient times until today. Lipsticks are a type of cosmetic used to enhance their appearance and protect the lips. Generally, waxes, oils, emollients, pigments, and varieties of dye or colouring agents are used to prepare lipsticks. Synthetic colours and other ingredients are hazardous to the human skin and body. Substituting synthetic ingredients with natu...
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STUDY OF DRUG RELATED PROBLEMS IN COMMON NEUROLOGICAL CONDITIONS AND INTERVENTION BY CLINICAL PHARMACIST IN A TERTIARY CARE HOSPITAL
Background: Drug-related problems are an ongoing, potentially harmful event that can affect the health of an individual. Various underlying health conditions and multiple drug uses are some of the factors contributing to drug-related problems (DRPs). This study aimed to determineDRPs in common chronic neurological conditions and intervention by clinical pharmacist in a tertiary care hospital, Indi...
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POLYPHARMACY PARADOX: UNRAVELING ENTERIC ULCER CONUNDRUM
Background/Aims: Polypharmacy, the concurrent use of multiple medications by a single patient, is common in modern healthcare to manage multiple comorbidities. While it helps address complex health conditions, it also brings significant challenges, such as increased risks of drug interactions and adverse effects, including the development of enteric ulcerlesions in the gastrointestinal tract. Meth...
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PHYTOCHEMICAL SCREENING, FUNCTIONAL GROUPS IDENTIFICATION BY FT-IR AND GC-MS ANYALYSIS OF CLERODENDRUM INFORTUNATUM L. LEAVES EXTRACT
The present investigation focuses on analysis of the active compounds present in the Clerodendrum infortunatum L. leaves extract of different solvents as Petroleum ether and methanol with help of the advance tools like GC-MS and FTIR which posses different pharmacological activities like wound healing, anti-inflammatory, anyalgesic, etc. The leaves were treated with petroleum ether followed by a 5...
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IN-VIVO ANTI-ULCER SCREENING OF METHANOLIC EXTRACT OF AMARANTHUS SPINOSUS
Background and Aim: The Amaranthaceae family have gained attention for their potential antiulcer properties. Peptic ulcers, a prevalent gastrointestinal disorder, necessitate the exploration of alternative therapies, and Amaranthaceae species may offer promising leads in this regard. Therefore, we have selected Amaranthus spinosus from the Amaranthaceae family for the evaluation of antioxidant and...
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A COMPARATIVE STUDY ON NUTRITIVE VALUE AND PHYSICO-CHEMICAL PARAMETERS OF ANDALUSIAN BREED OF DONKEY MILK WITH OTHER RUMINANT MILKS IN KAMAREDDY DISTRICT
Recently, there has been increasing interest in donkey’s milk. Donkeys’ milk is a good alternative source for infant nutrition in the case of cow milk protein allergy and substitute to human milk. The main aim of this study was to evaluate and compare the proximate composition and physico-chemical properties of Andalusian breed donkey milk with different species mainly buffalo, cow and goat mi...
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SYNTHESIS AND CHARACTERIZATION OF NOVAL SCHIFF BASE COMPLEXES OF MN(II), CO(II), NI(II), CU(II), ZN(II), PD(II), PT(II) METAL IONS FOR MICROBIAL ACTIVITIES AND THEIR NANOPARTICLES
New Schiff base metal ion complexes are synthesized and characterized by Mass, TGA, DTA, FTIR, UV-Visible, Conductivity, Magnetic properties, SEM, TEM EDX, and Elemental Analysis. The complexes have the general formula [ML2.H2O], where L=3-{(Z)-[(2-aminophenyl) methylidene] amino}-4-chlorobenzoic acid, and M= Mn (II), Co (II), Ni (II), Cu(II), Zn (II), Pt(II), and Pd(II). The Schiff base's imino, ...
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AN ANTIEPILEPTIC DRUGS FOR SEIZURE CONTROL IN EMERGENCY ROOM AND ASSESSMENT OF PATIENTS’ SATISFACTION TO ANTIEPILEPTIC MEDICATION IN TERTIARY CARE HOSPITAL
Background: Epilepsy is a common neurological disorder which results in significant morbidity. Epilepsy accounts for a significant proportion of the world’s disease burden, affecting around 50 million people worldwide. Aims: In this study, evaluate anti-epileptic drug for seizure control in Emergency room and effectiveness of various anti-epileptic drugs in terms of time to Seizure control. To a...
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EXPLORING THE EFFECTIVENESS OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS IN MIGRAINE MANAGEMENT: A COHORT PERSPECTIVE
Background: Migraine is a common neurological disorder that presents significant challenges in treatment. Effective management is crucial due to debilitating nature of the condition. Aim: This meta-analysis aims to evaluate efficacy of both pharmacological and non-pharmacological interventions in managing migraine symptoms. Methods: The analysis included 13 studies focusing on various intervention...
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FORMULATION AND EVALUATION OF RAPIDLY ORO-DISPERSIBLE TABLET CONTAINING VENLAFAXINE HYDROCHLORIDE FOR THE TREATMENT OF ANXIETY
Purpose: The main purpose was to develop Oro-dispersible tablet to overcome the problem of dysphagia which is common in pediatric, geriatric and unconscious patients. Method: The Oro-dispersible tablets were prepared by direct compression method by using two different individual superdisintegrant like Sodium Starch Glycolate and Crospovidone as well as combination of superdisintegrant with newly m...
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COMPARATIVE IN-VITRO STUDY OF ANTIMICROBIAL, ANTIFUNGAL OF SILVER NANOPARTICLES SYNTHESIZED FROM AQUEOUS AND ETHANOLIC LEAF EXTRACT OF GMELINA PHILIPPENSIS CHAM.
The development of a dependable green chemistry approach for the biogenic production of nanomaterials is an essential component of contemporary nanotechnology research. The biosynthesis of metal nanoparticles is a widely acknowledged method that employs a bottom-up approach with reduction as the primary process. When compared to chemical approaches, the nanoparticles created by this method are s...
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ATTENUATION OF HEMODYNAMIC RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION WITH TWO DIFFERENT DOSES OF LABETALOL IN CONTROLLED HYPERTENSIVE PATIENTS
Aim: The aim of the present study was to compare the efficacy of two different doses of labetalol for controlling these hemodynamic responses to laryngoscopy and tracheal intubation in controlled hypertensive patients. Material and Methods: Present study conducted on 90 patients posted for various elective surgeries under general anesthesia at our institute. Study populations were randomly divided...
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INDIA’S NATIONAL LIST OF ESSENTIAL MEDICINES 2022: A DESCRIPTIVE ANALYSIS
Objectives: The Indian government has revised the National List of Essential Medicines (NLEM) of India after seven long years in 2022. The objective of this study was to compare and analyse changes in the essential medicines listed in 2015 and 2022. We have also compared the listing of antibiotics in NLEM 2022 to those in the 23rd World Health Organization (WHO) Model list 2023. Materials and Meth...
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A STUDY ON ASSESSMENT OF DEPRESSION AND SLEEP DISTURBANCES AMONG PATIENTS WITH RHEUMATOID ARTHRITIS
The prevalence of Rheumatoid Arthritis is 0.1% to 1% and it is most common in developed countries. More than 2/3rd [54%-70%] of patients with RA have sleep disturbances. In RA multiple episodes of inflammation are predictive of an increased risk of developing depression. The prevalence of depression in individual RA ranges 14% to 48%. Sleep disturbances & depression in those with RA patients w...
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EVALUATION OF THE ANALGESIC EFFECT OF THE COMBINATION OF INTRA-CANAL ANALGESICS AND CRYOTHERAPY IN CONTROLLING PAIN DURING NON-SURGICAL ROOT CANAL TREATMENT – A RANDOMIZED CONTROL STUDY
Aim: Patients often experience varying degrees of pain during or after root canal therapy. This study aimed to the analgesic effect of the combination of intra-canal analgesics and Cryotherapy in controlling pain during non-surgical root canal treatment. Methodology: This Double-blind, parallel, randomized clinical trial included 76 patients (42 men and 34 women) within the age range of 18-65 year...
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