Volume 16 (2025) - Issue 11, November
Review Articles
REVIEW ARTICLE ON QBD APPROACHES TO IMPROVE NANOTECHNOLOGY BASED DRUG PRODUCT
Quality by Design (QbD) is a systematic approach in pharmaceutical development that focuses on predefined objectives, scientific understanding and quality risk management. It involves defining a Quality Target Product Profile (QTPP), identifying Critical Quality Attributes (CQAs), Critical Material Attributes (CMAs) and Critical Process Parameters (CPPs). It is implemented for control strategies t...
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NUCLEAR MEDICINE: A COMPREHENSIVE REVIEW
Nuclear medicine is a branch of medicine that evaluates body functioning and diagnosis and treats the disease by using radiopharmaceuticals or radio tracers. 131-iodine was the first commercially used nuclear medicine for the diagnosis and treatment of thyroid disease. Nuclear medicine emits alpha, beta (ß- and ß+) and gamma rays, which are used for the diagnosis and treatment. Nuclear imaging s...
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THE IMPACT OF AGE-RAGE PATHWAY IN BREAST CANCER: NOVEL STRATEGIES FOR TREATMENT AND PREVENTION
The receptor for advanced glycation end-products (RAGE) and its ligands, particularly advanced glycation end-products (AGEs), serve as a crucial molecular link between diabetes and breast cancer. Chronic hyperglycemia and insulin resistance in diabetes promote excessive AGE formation, which, upon binding to RAGE, triggers inflammatory and oncogenic signaling cascades, including NF-κB, PI3K/Akt, M...
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NEEM, ALOE VERA, AND TURMERIC: A REVIEW OF THEIR SYNERGISTIC POTENTIAL IN POLYHERBAL CREAMS FOR PSORIASIS SCAR MANAGEMENT
Psoriasis, a chronic inflammatory skin condition, which leads to residual scarring to patients. Conventional treatments for these scars have limitations, driving interest in herbal remedies. This review examines the potential of Neem (Azadirachta indica), Aloe vera (Aloe barbadensis Miller), and Turmeric (Curcuma longa), individually and in combination, for managing psoriasis scars, particularly w...
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GREEN NANOTECHNOLOGY IN FOCUS: PLANT-MEDIATED SYNTHESIS AND APPLICATIONS OF BISMUTH NANOPARTICLES
The green synthesis of bismuth nanoparticles (BiNPs) using plant extracts presents a sustainable and eco-friendly alternative to conventional nanoparticle fabrication methods. Bismuth, a low-toxicity post-transition metal, exhibits unique physicochemical properties suitable for applications in biomedicine, imaging, catalysis, and environmental remediation. Traditional synthesis approaches often in...
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Research Articles
FORMULATION AND DEVELOPMENT OF RIMEGEPANT LOADED IN-SITU NASAL GEL FOR TREATMENT OF MIGRANE BY EXTENDED-RELEASE DRUG DELIVERY
Migraine treatment efficacy is often limited by conventional oral delivery systems. The objective of this study was to formulate and optimize a thermoreversible in-situ nasal gel of Rimegepant to provide extended drug release and improve therapeutic effectiveness. Rimegepant-loaded thermoreversible in-situ nasal gels were formulated using varying concentrations of Poloxamer 407 and Gellan Gum thro...
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PHARMACOGENETIC QUALITY ASSESSMENT WITH IN-VITRO ANTIOXIDANT, ANTI-INFLAMMATORY, CYTOTOXICITY, AND ANTI-BACTERIAL POTENTIAL AGAINST PERIODONTAL PATHOGENS
Background: Herbal extracts have beneficial effects on humankind, so scientific research on their characteristics is necessary. Objective: Our investigation aims to analyze the pharmacognostical, phytochemical constituents, standardization, free radical scavenging activity, in-vitro anti-inflammatory activity, and cytotoxicity activity of the HAE of Ashvakatri, an herbal drug. Material and Method:...
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DESIGN AND EVALUATION OF SULPHONYL UREA DERIVATIVES AS THERAPEUTIC CANDIDATES FOR TYPE 2 DIABETES MELLITUS BY PERFORMING IN-SILICO STUDIES
Diabetes mellitus - Type 2 Diabetes Mellitus (T2DM) in particular - is a long-term inherent metabolic disorder that is seriously problematic with regards to global health. Sulfonylureas are a class of widely-used oral hypoglycemic drugs aimed at type 2 diabetes mellitus, targeting ATP-sensitive potassium channels through sulfonylurea receptor 1 (SUR1). This study intends to design and evaluate nov...
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CHEMICAL COMPOSITION AND GC-MS PROFILING OF THE STEM OF SYZYGIUM TAMILNADENSE (RATHAKR. & CHITRA), AN ENDEMIC SPECIES OF THE WESTERN GHATS, NILGIRIS, TAMIL NADU, INDIA
Plants have evolved to produce a vast array of natural compounds with significant health-promoting properties. Medicinal plants remain crucial resources for contemporary drug discovery and development. This study presents the first scientific investigation into the medicinal potential of Syzygium tamilnadense (Rathakr & Chitra), a rare and endemic species of the Myrtaceae family native to the ...
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2,4,5-TRIPHENYL IMIDAZOLE: DESIGN AND IN-SILICO STUDIES OF 2,4,5-TRIPHENYL IMIDAZOLE DERIVATIVES AGAINST COVID-19 MAIN PROTEASE (MPRO:6Y84)
This paper deals with the in-silico evaluation of novel 2,4,5-triphenyl imidazole derivatives for their antiviral activities. The 2,4,5-triphenyl imidazole is synthesized using a traditional method that uses benzil, ammonium acetate, benzaldehyde, and glacial acetic acid, and characterized using IR spectroscopy. A series of 2,4,5-triphenyl imidazole derivatives 3(a-f) and 4(a-f) were designed by u...
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ANALYSIS OF CAESAREAN SECTION RATE ACCORDING TO MODIFIED ROBSON’S CLASSIFICATION AT TERTIARY CARE CENTRE IN JAIPUR, RAJASTHAN, INDIA
According to WHO guidelines and US Healthy initiative 2000, the cesarean section rate should not be beyond 15 %. The aim of this study is to analyze caesarean section rate at tertiary care centre according to Modified Robson’s classification. Methods: The present study was carried out retrospectively at Department of Obstetrics & Gynecology, SMS Medical College, Jaipur, Rajasthan from May 20...
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FORMULATION AND EVALUATION OF CIPROFLOXACIN NIOSOME GEL FOR OCULAR DELIVERY
This study aimed to formulate and evaluate ciprofloxacin-loaded niosomes for sustained ocular drug delivery and enhanced bioavailability by increasing residence time in the eye. Niosomes were prepared via thin film hydration using Tween 80, 60, and 20 at three different concentrations, keeping cholesterol and drug ratios constant. These vesicles were assessed for drug encapsulation efficiency and ...
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COMPUTATIONAL DESIGN, SYNTHESIS, ANALYSIS AND EVALUATION OF NEW SPIRO [INDOLINE-THIAZOLIDINE] DERIVATIVES FOR ANTI-INFLAMMATORY AND ANTIOXIDANT PROPERTIES
In this study, a series of novel N-(2,4'-dioxospiro[indoline-3,2'-thiazolidin]-3'-yl) isonicotinamide derivatives (VIa-l) were synthesized by cyclizing N1- (2-mercaptoacetyl) isonicotinohydrazide with various 5,6,7-substituted isatins. Structural confirmation of the new compounds was achieved using IR, Mass, H1, and C13 NMR spectroscopy techniques. In-silico molecular docking studies were conducte...
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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF BUPIVACAINE AND MELOXICAM IN SYNTHETIC MIXTURE
Bupivacaine and Meloxicam are used in combination for treatment of Pain relief. Objective of present work was to develop simple, precise, accurate methods for simultaneous estimation of both drugs using HPTLC and RP-HPLC method. In HPTLC method silica gel G- F254 TLC plate as a stationary phase and a mobile phase of Toluene: Ethyl acetate: Methanol: Formic acid (6:2:1.5:0.5 v/v/v/v) used to resolv...
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A STUDY OF THE PRESCRIPTION PATTERN OF ANTIHYPERTENSIVE DRUGS IN PREGNANCY INDUCED HYPERTENSION IN A TERTIARY CARE TEACHING HOSPITAL IN ASSAM
Worldwide, hypertension represents one of the most common complications of pregnancy. Hypertensive disorders continue to occur globally, complicating 5-20% of pregnancies. Its incidence varies from 2 to 8% of pregnancies in developed countries reaching 10% or more in developing countries. Hypertension in pregnancy is defined as systolic blood pressure (sBP) ≥ 140 mmHg and/or diastolic blood pres...
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IDENTIFICATION AND CHARACTERIZATION OF IMPURITIES IN SULPHACETAMIDE INJECTABLE FORMULATION BY STABILITY-INDICATING UPLC-ESI-MS/MS METHOD FOLLOWING ICH GUIDELINES
Sulphacetamide is a sulfonamide antimicrobial widely used in injectable formulations for ocular and systemic bacterial infections. However, its chemical sensitivity to environmental factors poses a significant challenge for formulation stability, requiring a comprehensive impurity profiling approach. The current study aimed to develop and validate a stability-indicating UPLC-ESI-MS/MS method for t...
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PREVALENCE AND DRUG UTILIZATION PATTERNS OF GENITOURINARY TRACT INFECTIONS IN FEMALES OF REPRODUCTIVE AGE GROUP: A COMPREHENSIVE STUDY
Genitourinary tract infections (GUTIs) are a common health concern among females of reproductive age, with significant implications for reproductive and overall health. These infections can lead to complications such as Pelvic Inflammatory diseases, Pyelonephritis and Chronic kidney failure. Furthermore, this leads to poor social and economic impact, particularly in developing nations such as Indi...
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PHARMACOLOGICAL TREATMENT OF ALCOHOL DEPENDENCE SYNDROME IN A TERTIARY CARE HOSPITAL – A CROSS-SECTIONAL STUDY
Alcohol dependence syndrome (ADS) is an important condition causing significant morbidity and mortality contributing to 20-30% of all hospital admissions in India. There are various pharmacological agents available that are equally effective in the treatment of ADS along with psychotherapy. Hence this study is conducted. This is a cross-sectional study conducted in the inpatient department of Psyc...
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A PROSPECTIVE OBSERVATIONAL STUDY ON PRESCRIBING PATTERN ANALYSIS IN DERMATOLOGICAL DISEASES: A TERTIARY CARE HOSPITAL IN TAMIL NADU
Dermatological disorders are among the most common ailments seen in outpatient departments in India. Rational prescribing plays a critical role in ensuring safe and cost-effective therapy for such patients. This prospective observational study was conducted to analyse the prescribing patterns in the dermatology outpatient department of a tertiary care hospital over a six-month period. A total of 2...
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BEYOND THE BIN: EXPLORING KNOWLEDGE ON BIOMEDICAL WASTE MANAGEMENT AMONG NORTHERN INDIA’S HEALTHCARE WORKERS
Background: Poor management of biomedical waste (BMW) poses severe health and environmental risks, especially during the COVID-19 pandemic that saw an excess of infectious waste. The Biomedical Waste Management Rules of 2016, subsequently amended in 2018, provide guidelines for safe disposal; however, there remain considerable gaps in knowledge among healthcare personnel. The present research asse...
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FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF COLCHICINE
This study aimed to develop and assess a fast-dissolving oral film (FDOF) for colchicine, targeting enhanced patient compliance and rapid therapeutic onset, particularly for acute gout management. Colchicine, a powerful anti-inflammatory medication, often faces patient adherence challenges due to gastrointestinal side effects and delayed onset in conventional oral forms. FDOFs offer a compelling a...
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A VALIDATED STABILITY-INDICATING HPTLC-PDA METHOD FOR TOLNAFTATE BULK AND STANDARD DRUG
To estimate Tolnaftate in the presence of its forced declination products, a straightforward and quick stability indicating High Performance Thin Liquid Chromatography -Photo Diode Array (HPTLC-PDA) approach was created and validated. The methodology used Toulene: Chloroform: Methanol (311 v/v) as mobile phase and SunQSil C18 column (250mm×4.6mm, 5µm) as stationary phase. Retention time of tolna...
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IMAGING SPECTRUM OF TESTICULAR TUMOURS ON DOPPLER SONOGRAPHY
This study investigates the imaging characteristics of testicular tumors through the use of Doppler sonography, emphasizing its significance as a first-line, non-invasive diagnostic modality for the evaluation of testicular masses. Testicular tumors represent a significant clinical concern due to their potential malignancy and impact on male reproductive health. High-resolution ultrasonography com...
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