Volume 16 (2025) - Issue 10, October
Review Articles
INVESTIGATING HERB-DRUG INTERACTIONS: THE EFFECT OF TINOSPORA CORDIFOLIA ON CYTOCHROMES P450 METABOLISM, CLINICAL IMPLICATIONS AND GUIDE TO HEALTHCARE PROFESSIONALS
Tinospora cordifolia (TC), family Menispermaceae, a widely used herb in Ayurvedic formulations, is known for its therapeutic advantages in the treatment of fever, urinary problems, managing diabetes, metabolic disorders, dysentery, and enhancing immune function. However, its concurrent intake with commonly prescribed drugs raises alarms about potential herb-drug interactions. This review objective...
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ADDRESSING THE GLOBAL THREAT OF ANTIMICROBIAL RESISTANCE: EMERGING APPROACHES, INNOVATIONS, AND RETHINKING STRATEGIES FOR FUTURE CONTROL
Antimicrobials are vital agents that combat dangerous microorganisms, but increasing resistance to these drugs is a major challenge to global health security. AMR occurs when the intended killing drugs lose their effectiveness because pathogens have learned how to adapt and become resistant to them mainly as a result of overusing, misusing or using antibiotics in ways that are not suitable. Adheri...
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OPHTHALMIC MONKEYPOX: A COMPREHENSIVE REVIEW ON OCULAR INVOLVEMENT, DIAGNOSIS, TREATMENT AND VACCINATION
Ocular monkeypox, a rare but severe consequence of monkeypox virus infection (an Orthopoxvirus), presents with various ophthalmic issues, from conjunctivitis and keratitis to, in severe cases, corneal ulcers and vision loss. Transmission occurs via Close contact with sick people, contaminated objects, or respiratory droplets can spread the infection. Among the symptoms include inflamed eyes, swell...
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A COMPREHENSIVE REVIEW OF FORMULATION METHODS OF CHEWABLE TABLET- A NOVEL APPROACH
Chewable tablets are produced using various manufacturing processes, each with its own unique characteristics and advantages. The most common method includes wet granulation, dry granulation, direct compression, extrusion, melt granulation, fluid bed granulation, compression coating, 3D printing. Each process offers distinct benefits, such as improve tablet strength better taste masking and increa...
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EXPLORING THE MEDICINAL POTENTIAL OF DRACAENA REFLEXA LAM.: A COMPREHENSIVE REVIEW OF ITS THERAPEUTIC APPLICATIONS
Ayurveda is the traditional frame of health care known since old times. Dracaena reflexa is a plant of the Asparagus family with a few important phytochemical constituents utilized to treat different illnesses. In particular, its uses were widely employed in the traditional system of medicine. The present review was pointed to evaluate the phytochemistry, pharmacological properties, botanical desc...
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INNOVATIONS IN NASAL FORMULATIONS: ADVANCES IN TREMOR TREATMENT
Tremors are a neurodegenerative disorder (ND) characterized by the involuntary movement of body parts such as the soft palate, hands, jaw, tongue, and head. As of February 2020, the Online Mendelian Inheritance in Man (OMIM) database contained over 594 genetic conditions. Tremors can originate due to improper functioning of certain areas of the brain or due to genetic inheritance and is prominentl...
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REVIEW ON BIOSYNTHESIS OF NANOPARTICLES AND ITS ROLE IN TARGETED DRUG DELIVERY
Bio-nanotechnology has emerged as an integration of biotechnology and nanotechnology. The nanoparticles are described as particles with sizes ranging from 1 to 100 nanometers. Nanoparticles exist in many forms such as spherical, cylindrical, platelets, tubes, etc. Nanotechnology is an area that is flourishing, creating an effect in all fields of human life. Biological synthesis employs plant leaf ...
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INTEGRATED CARDIAC ELECTROPHYSIOLOGY: FROM DIAGNOSIS TO THERAPY IN ARRHYTHMIA MANAGEMENT
Cardiac electrophysiology has undergone significant advancements in recent decades, revolutionizing the diagnosis and treatment of heart rhythm disorders. This narrative review explores the integration of diagnostic and therapeutic approaches in modern arrhythmia management. We discuss the evolution of electrophysiology studies, highlighting their crucial role in guiding ablation procedures and tr...
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Research Articles
STABILITY OF REBAUDIOSIDE M UNDER ACIDIC CONDITIONS AND ITS DEGRADATION PRODUCTS
Current study aims to evaluate stability of Rebaudioside M, a sweet component of Stevia rebaudiana, using a typical pH (2.8, 3.2, 3.8 and 4.2) and temperature (5 °C, 20 °C, 30°C, 40 °C) for 26 weeks, range that simulated both relevant and extreme beverage storage conditions. Photostability of mock beverages at pH 3.8 was determined at 25 °C /60% relative humidity (RH) with fluorescent light e...
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SENSORY AND NUTRITIONAL PROFILING OF SAUROPUS ANDROGYNUS LEAVES BY MEANS OF DRYING TECHNOLOGIES
Objective: The purpose of this study was to compare the impact of various drying methods, such as sun drying, Sunshade drying, hot air oven drying, and Deep freeze-drying technologies, on the elucidation of sensory and nutritional profiles in Sauropus androgynous leaves. Methods: Fresh Sauropus androgynous leaves were used for various drying techniques, such as Sunshade, sun drying, hot air oven, ...
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FASCIN 1 IN UROTHELIAL CARCINOMA OF THE URINARY BLADDER: EVALUATION AND ITS CORRELATION WITH PATHOLOGICAL STAGE OF THE TUMOR
Introduction: In urothelial carcinomas, the degree of invasion plays a major role in prognostication and treatment assessment. In certain instances, evaluating invasion on standard histopathological sections may be challenging. Actin-bundling protein fascin is implicated in the migration of tumour cells and is expressed more intensely in invasive tumours. Objectives: To evaluate the expression of ...
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RANDOMIZE CONTROL TRAIL OF HYPERTENSIVE PATIENTS UNDERGOING QUALITY OF LIFE INVESTIGATION
Background: The study assesses lifestyle management of CAD in a tertiary care center, focusing on patients demographics and quality of life (QOL) among hypertensive female patients. Materials and Methods: This descriptive and interventional study was conducted. A total of 140 hypertensive women were selected using simple random sampling. Inclusion criteria included female patients with a documente...
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INFORMATIVENESS OF EPIGENETIC CHANGES IN THE SIGIRR GENE IN INFANTS WHO DIED FROM NECROTIZING ENTEROCOLITIS
Necrotizing Enterocolitis (NEC) is a severe gastro-intestinal disease primarily affecting premature infants, especially those born at or before 32 weeks of gestation, and is associated with high morbidity and mortality rates, characterized by intestinal inflammation and necrosis. The purpose of this study was to investigate the role of genetic factors in the development of necrotizing enterocoliti...
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IN-VITRO AND IN-SILICO STUDY OF BUTEA MONOSPERMA FLOWER
The active compounds present in plants gained attention for their biological activity and this makes them important for the pharmaceutical industries. Butea monosperma has significant role in traditional medicines. Its leaves, bark, and flower have an important role against diabetes, filariasis, ulcers, inflammations, etc. However, till date no detailed phytochemicals profiling in flowers of B. mo...
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EFFECTIVENESS OF POST-EXPOSURE ANTI-RETROVIRAL PROPHYLAXIS IN BABIES BORN TO HIV-POSITIVE MOTHERS AT GOA MEDICAL COLLEGE: A RETROSPECTIVE STUDY
Vertical transmission remains a major contributor to paediatric HIV infections despite significant advancements in antenatal care and the use of antiretroviral therapy (ART) and post-exposure prophylaxis (PEP). These measures have successfully reduced mother-to-child transmission rates, yet non-compliance with prescribed regimens continues to pose significant challenges. This retrospective study e...
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ASSESSMENT OF AWARENESS OF DEPRESCRIBING AMONGST DOCTORS OF A TERTIARY CARE HOSPITAL
Introduction: Deprescribing is an essential pillar in rational prescribing with literature citing a reduction in the number of drugs consumed, mortality and reducing referrals requiring emergency care by more than half, while also slashing healthcare cost. Deprescribing is a developing field with a steep learning curve due to prevalence of multiple prescribing sources (Ayurveda) and there is no co...
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KNOWLEDGE, ATTITUDE AND PRACTICE OF SELF-MEDICATION AMONG MEDICAL STUDENTS: A QUESTIONNAIRE-BASED STUDY
Background: Self-medication is a common practice among medical students due to their exposure to pharmacological knowledge and easy access to drugs. This reflects a gap between knowledge and behavior driven by perceived convenience and confidence in their medical knowledge. Objectives: To assess the knowledge, attitude, and practice (KAP) of self-medication among undergraduate medical students usi...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MYO-INOSITOL AND METFORMIN HYDROCHLORIDE IN BULK AND DOSAGE FORM
A simple, sensitive, specific, accurate reversed phase high performance liquid chromatographic method was developed for the simultaneous estimation of Metformin HCl and Myo-Inositol in bulk and pharmaceutical dosage form. RP-HPLC separation was achieved on C-18 (250mm x 4.6mm, 5µm) column. The mobile phase composed of Water: Acetonitrile: Methanol (50:30:20 % v/v/v) [HPLC Grade] at flow rate 1ml/...
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PHYTOCHEMICAL PROFILING OF ASTERACANTHA LONGIFOLIA AND MORINGA OLEIFERA: A COMPARATIVE ANALYSIS OF SOXHLET AND MICROWAVE-ASSISTED EXTRACTION METHOD
Plants have rich deposits of phytochemical constituents, which are responsible for their medicinal uses. Different extraction methods like Soxhlet and microwave-assisted extractions are used to isolate these phytochemicals from plant materials. However, there is a lack of studies on a comprehensive comparison of phytochemical profiles obtained from different plant materials using Soxhlet and micr...
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ASSESSMENT OF SILVER NANOPARTICLES DERIVED FROM AVERRHOA CARAMBOLA LEAF EXTRACT AS A NOOTROPIC -INTERVENTION FOR ALZHEIMER’S DISEASE
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is characterized by cognitive decline and memory impairment, often associated with oxidative stress, amyloid plaque accumulation, and neuroinflammation. In the quest for alternative therapeutic strategies, nanotechnology combined with phytochemistry offers a promising avenue. This study investigates the synthesis, characterizati...
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IN-SILICO COMBINATORIAL INHIBITION EFFECT ANALYSIS OF NSAIDS AGAINST MMP-9 FOR THE TREATMENT OF CANCER
Overexpression of Matrix metalloproteinases (MMPs) in cancers promotes tumor by degrading the barrier of extracellular matrix and angiogenesis. MMP-9 plays a major role in the progression of cancers by enhancing migration, cell survival, angiogenesis, epithelial-to-mesenchymal transition, immune response induction, and tumor microenvironment formation thus, it is considered as a lead drug target t...
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PHARMACOGNOSTIC STUDY OF THE FRUIT AND SEED OF SEABUCKTHORN (HIPPOPHAE RHAMNOIDES SUBSP. TURKESTANICA ROUSI) – A SUPER PLANT OF THE COLD DESERT OF INDIA
Hippophae rhamnoides subsp. turkestanica Rousi. (seabuckthorn), a multipurpose plant growing in the cold desert of the Union Territory of Ladakh, India. The plant samples were collected from Skurbuchan, located at 34° 26' 07" N and 76° 42' 38" E, along the Indus River bank in the Union Territory of Ladakh, India. The samples are shade-dried. The microscopic observations are examined under diff...
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SPECTRAL ANALYSIS OF PETROLEUM ETHER AERIAL PART EXTRACT OF GRANGEA MADERASPATANA USING GAS CHROMATOGRAPHY-MASS SPECTROMETRY
Grangea maderaspatana, commonly known as Madras carpet / Indian chickweed and belonging to the Asteraceae family. This plant is widely distributed throughout the tropical and subtropical regions of Asia and Africa and traditionally employed in the management of respiratory, gastrointestinal and dermatological disorders. Grangea maderaspatana plant has also demonstrated potential anti-inflammatory,...
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DRUG PRESCRIBING PATTERN IN SURGICAL WARDS IN A TERTIARY HEALTH CARE TEACHING HOSPITAL
Aim and Objective: evaluate the pattern of drug prescription in patients admitted in surgery wards of a tertiary care teaching hospital. Materials and Method: A prospective cross section observational study was conducted over a period of 6-months from January 2021 to June 2021 in surgical ward at tertiary care teaching hospital in Maharashtra. Patients above 18 years and receiving medical treatmen...
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PHARMACOLOGICAL ASSESSMENT OF ANTI-ANAEMIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF CURCUBITA PEPO SEEDS AND MACROTYLOMA UNIFLORUM GRAINS IN RATS
This study aimed to assess the anti- anemic activity of Macrotyloma uniflorum grains and Curcubita pepo seeds against Phenylhydrazine- induced anemia in albino rats. It was done by two extraction methods. In extract-1, Macrotyloma uniflorum was collected and soaked in water for whole night and next morning the grains were tied in a clean cloth and left for 3-4 days (Sprouted). The sprouted grains ...
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STUDY OF CLINIC PATHOLOGICAL EVALUATION OF PATIENTS PRESENTING WITH CERVICAL LYMPHADENOPATHY IN A TERTIARY CARE TEACHING HOSPITAL
This dissertation investigates the clinicopathological characteristics of patients presenting with cervical lymphadenopathy in a tertiary care teaching hospital, with the goal of establishing a comprehensive diagnostic and management framework for this prevalent condition. The study analyzed a cohort of 150 patients, revealing that infectious etiologies accounted for 62% of cases, predominantly du...
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