Posted by admin on Oct 31, 2025 in |
Psoriasis, a chronic inflammatory skin condition, which leads to residual scarring to patients. Conventional treatments for these scars have limitations, driving interest in herbal remedies. This review examines the potential of Neem (Azadirachta indica), Aloe vera (Aloe barbadensis Miller), and Turmeric (Curcuma longa), individually and in combination, for managing psoriasis scars, particularly within polyherbal cream formulations. The review covers the phytochemical composition, pharmacological properties, clinical evidence, and mechanisms of action of these herbs, along with formulation considerations, safety profiles, and future research directions. Neem, Aloe vera, and Turmeric possess anti-inflammatory, wound-healing, and skin-regenerative properties. Combining them may offer synergistic benefits for improving psoriasis scar appearance. Further research is needed to validate these effects and develop standardized, effective, and safe polyherbal...
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Posted by admin on Oct 31, 2025 in |
The green synthesis of bismuth nanoparticles (BiNPs) using plant extracts presents a sustainable and eco-friendly alternative to conventional nanoparticle fabrication methods. Bismuth, a low-toxicity post-transition metal, exhibits unique physicochemical properties suitable for applications in biomedicine, imaging, catalysis, and environmental remediation. Traditional synthesis approaches often involve toxic reagents and energy-intensive processes, whereas green synthesis leverages phytochemicals such as flavonoids, phenolic, terpenoids, and alkaloids as natural reducing and stabilizing agents. This review explores various plant-mediated methods for synthesizing BiNPs, emphasizing how factors like pH, temperature, and reaction time influence nanoparticle morphology and functionality. Analytical techniques including UV-Vis, FTIR, XRD, SEM, TEM, and zeta potential analysis are discussed in relation to nanoparticle characterization. The biomedical applications of green-synthesized BiNPs, particularly their antibacterial, anticancer, and imaging potential, are examined alongside their role in photocatalytic degradation of environmental pollutants. While promising, the field faces challenges such as variability in plant extract composition, limited mechanistic understanding, and lack of standardization in synthesis protocols. Addressing these issues is essential for the scalable and reproducible production of...
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Posted by admin on Oct 31, 2025 in |
Quality by Design (QbD) is a systematic approach in pharmaceutical development that focuses on predefined objectives, scientific understanding and quality risk management. It involves defining a Quality Target Product Profile (QTPP), identifying Critical Quality Attributes (CQAs), Critical Material Attributes (CMAs) and Critical Process Parameters (CPPs). It is implemented for control strategies to ensure product quality, safety and efficacy by using tools such as risk assessment, Design of Experiments (DoE), Process Analytical Technology (PAT) and Ishikawa diagrams support QbD throughout the product lifecycle. Simultaneously, Nanotechnology has revolutionized drug delivery by improving solubility, bioavailability and targeted delivery. Nano-pharmaceuticals like liposomes, polymeric nanoparticles and nanosuspensions benefit greatly from QbD principles. Integrating QbD into nano-drug development enables better control of particle size, zeta potential, drug loading, and release kinetics, which are critical for performance and safety. Computational tools and design optimization techniques further streamline this development. The integration of QbD and nanotechnology enhances the reliability, effectiveness, and regulatory compliance of advanced drug products. This synergy not only accelerates innovation and improves therapeutic outcomes...
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Posted by admin on Sep 30, 2025 in |
Cardiac electrophysiology has undergone significant advancements in recent decades, revolutionizing the diagnosis and treatment of heart rhythm disorders. This narrative review explores the integration of diagnostic and therapeutic approaches in modern arrhythmia management. We discuss the evolution of electrophysiology studies, highlighting their crucial role in guiding ablation procedures and treatment planning. The review examines radiofrequency ablation techniques, their mechanisms of action, and outcomes across various arrhythmia types. We also explore the progress in pacemaker technology, from traditional devices to leadless and physiological pacing systems. The synergistic use of these technologies in clinical practice is emphasized, demonstrating how their integration enhances patient care. We analyze patient outcomes, comparing the effectiveness of medical and interventional approaches, and discuss long-term safety and efficacy data. The review addresses special considerations for pediatric and elderly populations, as well as patients with comorbidities. Cost-effectiveness and resource utilization in electrophysiology procedures are also examined. Looking to the future, we highlight emerging technologies and approaches, including advanced mapping systems, novel energy sources for ablation, and the potential...
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Posted by admin on Sep 30, 2025 in |
Ayurveda is the traditional frame of health care known since old times. Dracaena reflexa is a plant of the Asparagus family with a few important phytochemical constituents utilized to treat different illnesses. In particular, its uses were widely employed in the traditional system of medicine. The present review was pointed to evaluate the phytochemistry, pharmacological properties, botanical description and microscopic characteristics of Dracaena reflexa leaves. The plant has a reliable number of important phytochemical constituents that are utilized as medications in different illness. Preparatory subjective phytochemical screening of Dracaena reflexa leaves extracts showed the presence of number of phytoconstituents such as alkaloids, flavonoids, terpenoids, saponins, amino acids, tannins, steroids, glycosides, carbohydrates and fats. Presence of these compounds contribute to the plant’s potential therapeutic properties, including antioxidant, pain relieving, anticonvulsant, anti-inflammatory, antimicrobial activities and wound healing properties. Further research into the pharmacological potential of Dracaena reflexa may reveal its therapeutic benefits. Various research findings suggested that Dracaena reflexa might be a valuable herbal medicine for a range of sicknesses, both...
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