Posted by admin on Aug 31, 2022 in |
The interaction/incompatibility of drug excipients is a major concern in formulation generation. Compatibility tests for drug excipients constitute an important step of the production of all dosage forms in the preparation stage. The possible physical and chemical interactions of drugs and excipients can influence chemical, physical, therapeutic properties and the dosage form’s stability. The current review involves a fundamental mode of drug degradation, a process of physical, chemical and biopharmaceutical interaction between drugs and excipients. The study of incompatibility is explored in various thermal and nonthermal methods. Once the interaction form is identified, further steps can be taken to enhance drug and dose stability. Current and potential reviews of case studies relating to drug and excipient interactions and their unavoidable incompatibilities have also been studied to deepen greater information about such drug solution scenarios. From the review, we conclude that the subsequent use of the thermal and nonthermal methods provides information for the drug-excipient interaction, which can aid the production of safe dosage forms by selecting an...
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Posted by admin on Aug 31, 2022 in |
Litsea, an outsized genus comprising 400 species of evergreen trees or shrubs, distributed chiefly in tropical and subtropical Asia, Australia, and therefore the Pacific Islands, belongs to the Lauraceae. Litsea polyantha is found throughout North, East, and Central India at an altitude of 1,200 m. It is often planted as an ornamental plant. It is mostly grown as an honest source of fodder for the livestock. It is alittle to medium-sized evergreen tree attaining a height of 21 m and a girth of 1.8m. Barks are dark grey or pale brown colour, exfoliating in quite small polygonal corky scales. In Folklore medicines-Bark, Stem, Roots and Leaves are wont to treat various diseases and disorders. The bark of Litsea polyantha is mildly astringent and used for diarrhea. Powdered bark and roots are used for pains, bruises, contusions and for fractures in animals. Previous chemical investigation of this plant has revealed the presence of beta-sitosterol and actinodaphnine within the bark and an arabinoxylan containing D-xylose and L-arabinose during a molar ratio...
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Posted by admin on Jul 31, 2022 in |
Background: Guanfacine is a drug used to treat ADHD (attention deficit hyperactivity disorder) and treatment for hypertension from 1986, approved by the FDA. Recently it had been deduced that Guanfacine could also be employed in smoking cessation as a pharmaceutical aid. This could be attributed to the physiological effect that the drug has on the human body, such as decreased heart rate and blood pressure. An increase in heart rate and blood pressure leads smokers to light up a cigarette to ease their stress. Therefore, Guanfacine could be used potentially for nicotine cessation. Guanfacine could be used in combination with other conventional drugs already existing for this very purpose. It has to be mentioned that before employing this drug in the use of smoking cessation, a lot more studies have to be conducted with a much greater sample size to assess if there are any other adverse effects or any other limitations which could vary among different individuals and also assess the optimal amounts of dosage that would be...
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Posted by admin on Jul 31, 2022 in |
The novel coronavirus disorder 2019 (COVID-19) outbreak commenced in early December 2019 in the capital metropolis of Wuhan, Hubei province, People’s Republic of China and precipitated a world pandemic on march 11, 2020. Though some the international locations have succeeded in slowing down the price of the unfold of this pandemic, most the international locations throughout the globe are nevertheless persevering with To journey and growing vogue in the increase and unfold of this lethal disease. Hence, in the present day scenario, it has grown to be necessary to manipulate and eventually irradicate this lethal sickness using a nice vaccine. An RNA-based vaccine would possibly be greater superb than ordinary as vaccines to deal with a pandemic treatment. However, administration of acute seizures in sufferers with COVID19 as properly as administration of PWE and COVID19 wishes to think about doable drug-drug interactions between antiseizure capsules and candidate tablets presently assessed as therapeutic preferences for COVID-19. In this paper, we look at moral troubles and public conversation challenges associated with...
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Posted by admin on Jul 31, 2022 in |
Remarkable numbers of people have a false belief in naturally obtained herbal medicines as they are safe to use, omitting the fact that herbal medicines have pharmacological action like allopathic medicines. Many plants are poisonous and there is less safety data available for herbal medicines. Adverse drug reactions associated with herbal medicines are overdose and toxicity, herb interactions and hypersensitivity reactions. The potential side effects, the quantity of intake, risk of herbal medicines should be adequately developed. Herbal medicines, which are well studied, are not tested in the groups of the population like pediatrics, pregnant or breastfeeding women, geriatrics, or people with multiple co-morbidities. Many herbal medicines are under-examined, and their harmful effects sun known. The patients cannot be intimated properly about the risks and benefits unless the physician fails to show evidence about potency or side-effects of herbal medicines. The high demand for standard herbal medicines puts pressure on high-demand species and plants, leading to the extinction of selected species and plants. It is essential to take measures...
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