Posted by admin on Jun 30, 2022 in |
Mycosis is an opportunistic infection that attacks patients who are immunocompromised. Our immune system is designed to defend us against fungus and bacteria. The fungus can expand, penetrate and kill tissue because it lacks immunity. It’s everywhere, in soil and air and even in healthy people’s noses and snot, says the researcher. “As we work to defend ourselves from COVID-19 and live with it, another hazard termed Mucormycosis has emerged. Mucormycosis, a fungal infection caused by Mucor with a 50% fatality rate, maybe provoked by the administration of steroids, a life-saving treatment for severe and critically ill Covid-19 patients. Stay safe from Mucormycosis, a fungus that has been discovered in Covid-19...
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Posted by admin on Jun 30, 2022 in |
This manuscript aims to figure out updated information on the dry coating of powder (DCP). In pharmaceutical processes, the inevitable is handling of fine and ultra-fine particles (FUFP). Their higher surface area associated surface and surface attributes contribute chiefly to exhibited complex phenomenon like bulk behaviors, physicochemical property, performances and functionalities of pharmaceutical importance, and many others. Nowadays particle engineering techniques are extensively exploited to modify surface and surface attributes of FUFP to find their worthy applications and new functionalities. Among available diverse techniques for particle engineering DCP is advocated as a worthy and efficient one. The DCP is considered to have multidisciplinary applications in drug development and drug delivery. Process basis of DCP calls for attaching and/or fixing the particles of coating material (PCM) or guest particle (GuP) onto the substrate/core particle (S/CP) or host particle (HoP). Fixing/ attaching the PCM onto HoPs mandates their interaction that may be mechanical, chemical, thermal, electro-chemical and many others. Scientific literature and patents are evidencing diverse processes and methods for interacting...
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Posted by admin on Jun 30, 2022 in |
Herbal plants have long been known to have antifungal properties. The medicinal plants are prospective in aquaculture as an alternative to antibiotics and other anti-candida drugs. This article aims to review the reported herbal medicines with their research findings that have an enormous future prospective for the effective treatment of Candida infections. Various species of Candida were classified and their pathogenesis and mechanism of action were highlighted. Mechanisms of action of commonly used synthetic anti-candida drugs were compared to that of the herbal plants. Recent plant-based antifungal activity studies were analyzed. Ten species of candida, namely Candida albicans, Candida glabrata, Candida parapsilosis, Candida krusei, Candida dubliniensis, Candida lusitaniae, Candida guilliermondii, Candida rugosa, Candida zeylanoides and Candida tropicalis were found to be responsible for infection in human. Plant-based natural products were found to produce anti-candida actions based ongermination inhibition and formation of biofilm, cell metabolism, cell wall integrity, cell membrane plasticity, and induction of apoptosis. Around 20 research works were analyzed, and it was found that the majority of the...
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Posted by admin on Jun 30, 2022 in |
Polysaccharides are composed of monosaccharide’s linked by glycosidic bonds. These are abundantly available and are obtained from renewable resources. Polysaccharides provide an array of primary structures and conformations used in the pharmaceutical industry. Natural polysaccharides properties can be substantially modulated by chemical, physical, and enzymatic modifications and have received increased attention to expanding the landscape of application of polysaccharides in diverse sectors. Modifying the natural polysaccharides properties and structures gives functionally improved polysaccharides with excellent bioavailability, biocompatibility, structural stability, and versatile chemical. By modifying the physicochemical properties of polysaccharides, systems like micelles, hydrogels, liposomes, niosomes and vesicles are produced. The modified polysaccharides have a remarkable application in gene delivery, targeted cancer therapy, delivery of the drug, wound dressings, tissue engineering, nanocarriers, biosensors, pharmaceutical formulations, agricultural applications, and food industry. This article covers different types of polysaccharides and distinct methodologies applied during the new modified synthesis of polysaccharides and also the study of their properties after modification. This review also highlights the application of these modified polysaccharides in various pharmaceutical,...
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Posted by admin on Jun 30, 2022 in |
ACAT enzyme is found in human body and it maintains cholesterol homeostasis in the cell. This leads to deposition of cholesterol in our body as cholesteryl esters. Freely deposited cholesterol in the membranes of the cells is cytotoxic. This deposition causes atherosclerosis, Alzheimer’s disease, Xanthelasma, etc. The first substrate for ACAT is both medium & long fatty acyl CoA. Therefore, we studied the ACAT enzyme, its active site, location and activity to develop the inhibitors of ACAT as antihyperlipidemic agents with the heterocyclic compounds for drug designing. ACAT is having two active sites: histidine and aspargines. ACAT 1 is present in two chromosomes 1 and 7. Active site His-460 Of ACAT-I is responsible for catalysis. For docking studies these factors should be known so that the hetercyclic compound could be developed having inhibitory activity against ACAT. Further many literature review have been done to find a hetercyclic moiety having the antihyperlipidemic activity in which we found that benzene ring with thiazole and oxazole rings having side chain could get...
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