Posted by admin on Mar 31, 2022 in |
A progressive neurodegenerative brain disorder with motor & non-motor are signs of Parkinson’s disease or idiopathic parkinsonism. Parkinsonism is characterized in striatal region by the deterioration of Substantia nigra pars compacta & dopamine depletion in Dopaminergic neurons. In Parkinsonism research, the prime purpose is to recognize the pathogenesis, strategies & implementation of therapeutic frameworks that regulate the disease progress. Versions of toxins are even starting to be used to anticipate what might arise in individual Parkinson’s disease. There is indeed, ton of advancement to be developed especially with reference to the design of experimental models which can precisely determine productive clinical neuroprotective substances. For Parkinsonism research, modern pharmacological, neurotoxin-induced, genetically altered & cellular models become presently accessible. Although caution should be exercised in the initial detection of neurodegenerative illnesses, data imply that future progress is secure, possible and probable to boost clinical care. In this overview, comprehensive information on key features of in-vivo & in-vitro models presently available has been...
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Posted by admin on Mar 31, 2022 in |
Prunus amygdalus Batsch (family-Rosaceae), popularly known as Badam, Almond, is the most important familiar nuttree for global nut production that includes apples pears, prunes and raspberries. Almond seed skin is a prominent source of polyphenolic compounds, mainly phenolic acids, bioflavonoids, flavanones, isoflavones, flavonol glycosides and lignans that are reported in a ripened nut. Bioflavonoids such as flavanolglycosides, chieflycatechins, epicatechin, procyanidins and flavonol include 3-hydroxyflavone backbone glycosides, particularly isorhamnetin, isorhamnetin, naringenin and kaempferol are novel agents isolated from ripened seeds. The review aims to renew the interest in this promising plant, thus stimulating researchers to go further with the study for discovering novel medicinal agents for the treatment and management of several kinds of ailments. The present study compiled a detailed and unique summary of traditional folk medicine Prunus amygdalus based on screening the various databases from traditional textbooks, Science Direct, Google Scholar, PubMed, Elsevier, Springer Nature, and Research Gate, etc. The kernels of the seeds are a major source of vitamin E and B, dietary fiber, essential elements calcium and...
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Posted by admin on Mar 31, 2022 in |
Re-establishing blood flow in ischemia is essential for rescuing cells from necrosis in any tissue or organ. However, reperfusion post cerebral ischemia may worsen the condition and lead to “cerebral reperfusion injury”. In cerebral reperfusion injury, significant changes observed are infarct size, behavioural deficits, hematoma formation, inflammatory mediators, and oxidative stress markers that represent the extent of brain injury. Experimental in-vivo and in-vitro models mimicking the necessary neurological and pathological process are vital in the research of pathogenesis of cerebral reperfusion injury and the development of credible therapeutic drugs. This review explains the currently used in-vivo as well as in-vitro models to study cerebral reperfusion injury ranging from animal-based models like middle cerebral artery occlusion model, emboli stroke model, two-vessel occlusion model, four-vessel occlusion model, photochemical stroke model, collagenase induced brain haemorrhage model, autologous whole blood induced haemorrhage model to cell lines. Also, advanced technology likes the synthetic microvasculature model has been discussed. This review also provides contemplative facts to set up authentic and relevant animal models to study...
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Posted by admin on Mar 31, 2022 in |
Mucormycosis is a new fungal disease that increased the morbidity and mortality rate in this present scenario. It’s difficult to diagnose and cure due to proper scientific evidence is not yet being designed. The disease’s prevalence appears to be rising. In high-income nations, hematological malignancies are the most prevalent underlying illness, while uncontrolled diabetes is usually linked to pulmonary mucormycosis in low-income nations. Mucormycetes can be detected or identified using histopathology and molecular tests, and they can be recommended as important add-on techniques to augment standard diagnostic techniques. Reversal of underlying predisposing factors, early delivery of active antifungal medications at the appropriate dosage, thorough excision of all diseased tissues and different adjuvant treatments are all part of a successful therapy strategy mucormycosis. Liposomal amphotericin B antifungal medications have been added to our antifungal arsenal, but amphotericin B remains the medication of choice for first antifungal therapy. Despite attempts to better understand the pathophysiology of mucormycosis, early diagnosis and intensive treatment, the disease’s fatality rate remains...
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Posted by admin on Feb 28, 2022 in |
Imidazole has a special role in heterocyclic chemistry, and its derivatives have piqued interest in recent years due to its diverse chemistry and pharmacology properties. Imidazole is a nitrogen-containing heterocyclic ring that is essential in biology and pharmaceuticals. As a result, imidazole compounds have piqued the attention of researchers for more than a decade. Thus imidazole compounds have been an interesting source for researchers for more than a century. Antibacterial, anticancer, anti-tubercular, anti-fungal, analgesic, and anti-HIV activities are among the biological activities of imidazole derivatives. This paper aims to look back on the biological activities of imidazole over the years. A large number of imidazole derivatives are available. The incorporation of the imidazole nucleus is an important synthetic Strategy in drug discovery. The high therapeutic properties of imidazole-related drugs have prompted medicinal chemists to develop a slew of new chemotherapeutic agents. In clinical medicine, imidazole medications have a broader application in treating a variety of conditions. Imidazole can be synthesized using a variety of...
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