Posted by admin on Apr 30, 2022 in |
Bangladesh is gifted with the world’s largest bay, rich in untapped resources that are undeniably beneficial to human wellbeing and the national economy. However, the people of Bangladesh have not yet been capable of using the vast marine resources of the Bay of Bengal due to a lack of adequate funds and technological limitations. On the other hand, countries like Japan, China and Indonesia utilize their resources from the sea and develop therapeutic agents and molecules to produce efficient lifesaving drugs. Nowadays, marine habitat is considered one of the most resourceful areas for natural product research. Marine organisms possess enormous biological, biochemical, and biosynthetic potential. Likewise, bioactive compounds from marine microorganisms opened the door for novel therapeutic compounds discovery and development, i.e., anti-cancer, antibiotics, antifungals, and antiparasitic. Marine endophytes from algae and sponges are almost endless sources of novel compounds with numerous potential therapeutic applications due to their enormous diversity and intrinsic ability to create natural products of medical and pharmaceutical significance. There are nearly 257 pharmaceutical companies in...
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Posted by admin on Apr 30, 2022 in |
Inflammation is a host immune response initiated by the activation of inflammatory cascades resulting from any tissue injury. During the inflammatory response, multiple inflammatory mediators are released to restore the organ function and integrity by activating various inflammatory mediators. The presence of these molecules in the tumor microenvironment led to studies on the molecular pathways that are modulated during the inflammation to cancer transition. RB pathway is one such signaling pathway becoming more recognized in the microenvironments of pancreatitis and pancreatic ductal adenocarcinomas. RB1 is known to have multifunctional roles in the cellular growth and development processes, including apoptosis and autophagy. The RB protein in a dephosphorylated state negatively regulates the cell cycle at different checkpoints, thereby influencing the G1 to S phase progression. Besides its cell cycle activity, recent reports suggest that RB protein has a role in the pathogenesis of inflammation. The deregulation in the expression of RB protein is said to play an active role in stimulating the pro-inflammatory molecules, consequently resulting in inflammatory responses during...
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Posted by admin on Apr 30, 2022 in |
Perchlorate has been found in drinking water and surface waters in the United States of America, Canada, and India. It is primarily associated with the release of perchlorate from defense and military operations where rocket and satellite operation production takes place. Natural sources of perchlorate contain certain fertilizers and potash ores. Although it is a strong oxidant, perchlorate is very persistent in the environment. At high concentrations perchlorate can affect the thyroid gland by inhibiting the uptake of iodine. As per WHO gives a maximum tolerable daily intake of 0.01mg/kg body weight for perchlorate. Above 15 ppb intake of perchlorate, it changes normal to an abnormal condition of a living being. Perchlorate is measured in environmental samples primarily by ion chromatography. It can be removed from water by anion exchange or membrane filtration, biological and chemical processes. It remains stable for long times in water and soil in normal atmospheric...
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Posted by admin on Apr 30, 2022 in |
Food adulteration is an enduring concern to date, and its detection and food authentication are some of the major approaches which can eradicate adulteration. This article reviews modern analytical techniques which are currently used for optimization and identification of adulterants. The Analytical techniques reviewed are distributed in three sections- Computer vision, Spectral and spectral Imaging techniques, and Electrical Techniques. Computer vision is a very advanced technique, allowing the analysis of several parameters with accurate and precise results. The hazardous effect of adulteration and future challenges and impacts are briefly discussed. The Previous decade is considered to be a massive success for food adulterant detection as it involved a chemometrics study. The use of chemometrics with analytical techniques is briefly discussed. Chemometrics is the science of extracting information from the chemical system by data-driven means. The inevitability of food in perspective to the current COVID-19 pandemic is very strong, and authenticated food is a prior...
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Posted by admin on Apr 30, 2022 in |
In the last decades, diabetes has become one of the most prevalent health concerns worldwide. Diabetes is a metabolic disease that causes hyperglycemia and is associated with altered insulin production (type 1 diabetes) or with insulin-resistance (type 2 diabetes). The present work aims to point out the relevance of glipizide as an alternative treatment for type 2 diabetes and discuss the different delivery systems developed for this drug. With this in mind, we performed a nonsystematic search in different databases like PubMed, Google Scholar, Science Direct and the FDA’s and some other web pages, using key words as search criterion. Because glipizide is a drug with a short elimination half-life, a dosage of two to three tablets per day is needed, depending on the therapeutic requirements of each patient. The as aforementioned has led different research groups to develop new delivery systems for this drug; among them are nanoparticles, nanosuspensions, microspheres, self-emulsifying systems, matrix tablets, osmotic tablets, and gastroretentive systems. The developed systems have been aimed at reducing the...
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