Posted by admin on Apr 30, 2022 in |
Dementia, commonly Alzheimer’s disorder (AD), is a developing pandemic that presents profound challenges to healthcare systems, families, and societies in the course of the world. Alzheimer’s disorder, referred to as an innovative multifarious neurodegenerative disorder, is the essential motive for dementia in a late person’s life; brain developing older performs a pivotal feature in the pathogenesis and improvement of Alzheimer’s disease. Oxidative stress, a circumstance of unbalance between reactive oxygen species and antioxidants, provides a robust contribution to the excessive incidence of AD in old age subjects. The normal getting older technique is related to declines in positive cognitive abilities, such as processing speed and some factors of memory, language, visuospatial function, and executive function. Research in neurology has mounted decreases in the quantity of gray and white matter and upgrades in the feature of white matter that might also lead to cognitive changes determined with aging. It is necessary to think about these natural cognitive modifications because, first, they can have an effect on the daily functioning of...
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Posted by admin on Apr 30, 2022 in |
Antihistamines appear to be the mainstay in allergic reaction treatment. Allergy is rooted in the primary rejection reaction of parasites in which histamine derived from mast cells generates an immediate aggressive environment, and eosinophils are recruited for killing. Antihistamines are medicinal products used to treat allergic rhinitis, conjunctivitis, urticaria, cold and flu, tachyphylaxis, motion sickness, and acute allergic reactions. A vast number of animals can be used for this activity, with rodents (inbred mice and rats) and guinea-pigs being the most common models, which are easy to maintain and relatively economical compared to other available models. Therefore, animal models used in asthma are greatly useful in antihistaminic studies because they promise new insights into human allergic symptoms. The available in-vivo and in-vitro models are used to investigate the mechanism of action of drugs with antihistaminic activity. This work aims to bring all the different in-vivo animal models and in-vitro techniques together for conducting antihistaminic activity...
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Posted by admin on Apr 30, 2022 in |
Background: Over the last several years, there has been much research into the development and modification of new pharmaceutical substances. We have also been able to attain the newest in transdermal drug delivery system treatment with existing pharmaceuticals. We have successfully implemented numerous drug regimens with transdermal delivery systems as one of the most significant developments, offering numerous advantages. Main Body: The distribution of drugs takes place in a detached dose form from the skin-adhesive devices or patches by diffusing throughout the layer of skin to reach out systemic circulation. The worldwide market for transdermal drug delivery systems was reached United States Dollar 4,200.3 Million in 2016 with a predictable increase of compound annual growth rate at 7.5% over the estimated time (2017-2024). The factors like growth and increasing geriatric population in the chronic disease across the globe are promoting the development of the transdermal drug delivery market. Conclusion: We will examine the essential influence of pharmaceutical breakthroughs and the future prospects of non-invasive transdermal drug delivery systems in...
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Posted by admin on Mar 31, 2022 in |
Biosorption is a cure to atmosphere containing heavy metals and also an alternative to physical and chemical methods used for heavy metal removal. The main aim of this review is to highlight the various mechanisms of biosorption by using various biosorbent viz. microorganisms, no-living biomass, herbal plants for the removal of heavy metals. Industrialization, globalization has provided an ease to humans, but every comfort has its own disadvantages, in this case, it will increase heavy metal pollution which threatens the life of human, animals, and plants. Bio sorption used bio sorbent to remove heavy metal or sorbate and is economical. Nowadays, the natural biological material is used to remove heavy metals like vegetable waste and fruit peels. Herbal medicinal plants are also used to remove heavy...
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Posted by admin on Mar 31, 2022 in |
Costus igneus, commonly known as insulin plant, has been traditionally reported for its anti-diabetic, anti-oxidant, anti-inflammatory, anti-proliferative, anti-urolithiasis, hypolipidemic, neuroprotective and anti-microbial activity. This review is all about anatomical and morphological investigations of Costus igneus, including its medicinal use. Secondary metabolites of this plant such as b-sitostirol, corosolic acid, diosgenin, quercetin, catechine, oleic acid show mainly anti-diabetic activity. At present finding, Costus igneus have characteristic morphological, anatomical, and proximate features that could be used to differentiate it from other members of the Costaceae family. This review article collected information using the following searching engines such as Pub Med, Science Direct and Google Scholar, etc., and mainly focused on English written documents. The present review article attempts to explore various medicinal properties of Costus igneus (insulin plant) and mode of action of all major phytoconstituents as anti-diabetic activity for advanced research purposes and its suitable formulations development in the future for the welfare of...
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