Posted by admin on Jan 31, 2022 in |
Cancer is a diverse category of diseases involving the growth of unchecked cells. Cancer cells uncontrollably divide and expand, creating malignant tumours that can invade surrounded parts of the body. Carbon nanotubes (CNTs) consist solely of a carbon atom organized into a tubular form in a sequence of condensed benzene rings. These sheets are rolled at a particular and distinct angle and the properties of the nanotubes are determined from the combination of the radius and rolling angle. Because of their non-toxic nature and high fluorescence characteristics, carbon nanoparticles are shaped into a ligand that is unique to a highly expressed receptor for imaging and drug conveyance in malignant growth care. Carbon specks (C-dabs) and carbon nanotubes (CNTs) are leading the continuous discovery of carbon-based nanoparticles. CNTs are used as nano-carriers for anticancer drugs, including carboplatin, camptothecin doxorubicin via proper...
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Posted by admin on Dec 31, 2021 in |
Quality by Design (QbD) is an essential part of modern pharmaceutical development. QbD is a requisite for the design and development process for the pharmaceutical industry. QbD assists and encourages both the industries and FDA to inculcate a proactive, scientific and risk-based approach in the process and product development. It is based on a concept of building quality right from the start of the process rather than the final quality test of the finished product. An effective QbD approach provides insights and essential upstream throughout the development process which ultimately ends up offering a successful plan that reduces batch failures and recalls. It is also known as a structured lifecycle of product development and management. This review aims to present an overview of QbD implementation, its tools, elements, and methodologies, the involved ICH Guidelines, and the application in the current pharmaceutical sector. Under QbD, it is important to define the desired product performance profile i.e., Quality Target Product Profile (QTPP) and analyze, Critical Quality Attributes (CQA), Critical Process Parameter...
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Posted by admin on Dec 31, 2021 in |
Characteristics like dementia, behavioural and cognitive dysfunction, and memory decline may characterize Alzheimer’s disease (AD). A deterioration of short-term memory, inability to acknowledge new information, mood swings, difficulty recognizing words, forgetting names, and losing things are demonstrated by early disease. Popular emotional characteristics displayed by patients with AD are anger, aggression, and irritability. Today’s world attempts to treat various ailments have increased with medical advancements. There is still considerable research into medications capable of preventing or at least effectively altering the trajectory of AD, referred to as ‘disease-modifying medicines. Laboratory animals are helping to test new ways of treating illness. For the goal of developing therapeutics or disease-modifying agents, a vast array of experimental models were developed to simulate the human context of the illness. In animal studies, AD caused by chemical compounds may be helpful in deeper understanding the mechanism of disease and AD treatment. The anticholinergic drug Scopolamine induces amnesia in rodents. This analysis examines the various animal models frequently used to research the effect of novel...
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Posted by admin on Dec 31, 2021 in |
Tissues can be preserved for centuries under the conditions of extremely cold temperatures along with the neurological functions of the human brain. It is possible with the process of vitrification; here the cells of the brain are cooled to the cryogenic temperature without the formation of ice. Damage caused due to this process is theoretically reversible as like before, but practically, rejuvenation is possible only by the foreseeable technology which is specific. Injury caused to brain because of low or stopping of blood flow which is as a result of complex series of process which takes more than 6min of time to complete the limit of resuscitation technology. Damage of blood vessels occurs first then the brain tissues if the process of rejuvenation occurs for more than 6 min. For permanent death of neurons, many hours are required. The process of cryopreservation provides a chance for resuscitation by having an opportunity between legal death and permanent loss of life in both humans and animals. At appropriate conditions, the time...
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Posted by admin on Dec 31, 2021 in |
SARS-CoV-2 viral cause infection called COVID-19 was initially reported in China has resulted in a pandemic because it has spread in over 210 countries. This review summarized pathophysiology, clinical features, diagnosis, and COVID 19. The spread of SARS-CoV-2 viral infections is a matter of concern because of a mutant variant of virus. The COVID-19 infection is having 14 days incubation period. Fever, sore throat, cough, severe headache, breathlessness, myalgia and weakness are common symptoms observed in patients with COVID-19. Steps of replication of SARS-CoV-2 virus are attachment, penetration, uncoating, replication, assembly and release. Patients’ screening tests are complete blood count, C-reactive protein (CRP) and erythrocyte, sedimentation rate (ESR), D-dimer, serum ferritin, and others. The reverse transcription-polymerase chain reaction (RT-PCR) is the important diagnostic test of molecular genetic assays for detecting viral RNA. In-Patient of COVID 19 CT scan shows ground-glass opacities with or without consolidations in lung regions. In CT scan, standardized assessment scheme is CORAD classification and assessment of lung involvement can be done CT severity score index....
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