Posted by admin on Mar 31, 2022 in |
Natural molecules from plants are vital sources to explore potent lead molecules in the drug discovery process. Plants as A source of medicine is an ancient practice in India. The Indian subcontinent is a wide repository of medicinal plants that are being used in the traditional system of medicines. Kalanchoe is one of the medicinal plants; the succulent leaf juice is prepared by grinding the leaves mechanically and is a Tyler-made medicine being prescribed by traditional practitioners to combat various diseases and disorders. Various species of Kalanchoe find an important place in traditional medicine across the globe. This review article is a systematic compilation of recent updates on the worldwide ethnopharmacological uses and phytomolecules as therapeutic markers, pharmacological profiles, pharmacokinetic studies and SAR of bufadienolides from varied species of Kalanchoe. The systematic compilation of review articles will direct the scientific community to focus their research by doing further molecular and targeted throughput screening of the lead molecules from Kalanchoe, results in drug discovery from the potent herbal plant Kalanchoe....
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Posted by admin on Mar 31, 2022 in |
Tea brewed from the plant Camellia sinensis is the second most popular beverage consumed worldwide after water. The first two leaves and the leaf bud are mainly used for commercial tea production, and depending on the variation of processing techniques, it is primarily categorized into -white tea, green tea, oolong tea, and black tea. Different varieties of tea are known for their contribution in little to a large amount of bioactivity or sensory attributes due to variation in the chemical constituents, thus providing health benefits. Throughout the years green tea has been extensively investigated by researchers for its health benefits; however, black tea is now emerging as more beneficial to health and catching serious attention by researchers. Apart from the methylxanthines, amino acids, phenolics, and catechins, the two major components, i.e., the TFs and TRs are solely responsible for black tea’s characteristic color and taste and are proven to have health benefits. This review aims to provide available information on Theaflavins (TFs), their bioactivity, and, most importantly, the various...
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Posted by admin on Mar 31, 2022 in |
Rheumatoid arthritis (RA) is a general inflammatory disorder touching about 1.3% of the grown-up census of the world. Over the last two decades, a significant development has been done in the thoughtfulness of RA pathophysiology, best outcomes, and successful treatment strategy, and the credit of the significance of diagnostic agents and treating RA near the beginning. Earlier than novel treatments were obtained, RA caused notable incapability and deaths. At present, it is customary that principal diagnostic agents and therapy are significant and helpful. Development in the treatment of RA made it likely to manipulate signs in inflammatory arthritis. The early hour diagnosis and treatment of RA can prevent or reduce the progression of joint erosion to about 90% of patients; by this means irreversible disability can be prevented. In advance and more effective treatment significantly improves the prognosis of RA. The advancement of novel instruments to assess disease activity and recognize remission has brought about innovative treatment strategies to inhibit RA ahead of joint damage forever. The pharmacological therapy...
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Posted by admin on Mar 31, 2022 in |
The majority of current drug delivery systems are existed as water-insoluble drug delivery systems but rarely water-soluble drug delivery systems. Low aqueous solubility is a common problem in pharmaceutical development. About 40% of commercialized drugs and as many as 90% of drugs in the discovery are low aqueous soluble. When given through traditional dosage forms, such drugs fail to be soluble and have limited bioavailability, so they tend to show limited therapeutic effect and often fail. Various methods to solubilize drugs usually involve a combination of pH modifiers, salt forms, co-solvent systems, surfactants, or complexation. A complex drug system is generally a complex system incorporated with API and compatible excipients to produce the desired effect. Complex drug systems are simply referred to as uncommon products that were not typical tablets. However, with the rise of insoluble API biologics, complex drug systems are quickly gaining importance. Most used complexes include phosphor lipid complex, chitosan complex, cyclodextrins complex, phosphatidylcholine complex. Complex drug systems are employed in various areas for treating various...
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Posted by admin on Mar 31, 2022 in |
The presentation of this work aims to update professionals on issues associated with selecting the film former in the film coating process. Film coating finds applicability in a diverse field that may be for conventional (immediate) release and modified-release intended for enteric/ delayed-release or barrier membrane controlled release (extended-release). In the pharmaceutical field, film coating of the substrate is achieved by spraying the coating material in liquid medium onto them. The formulation of coating material is a solution or dispersion of film-forming polymers and excipients in aqueous or organic solvents. Film formers are the chief amongst the component of coating formulation that delineates the functional properties of the film-coated pharmaceutical along with other factors like additives, process, equipment, technology and many others. Polymers used as film former are available in different grades, determined by their molecular weight and viscosity. Their glass transition temperature (Tg), along with the grade of polymer, influences the film coating process along with the functional properties of the film coat. Summarised information on the technical...
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