Posted by admin on Mar 31, 2022 in |
Ziziphus rugosea member of Rhamnaceae family, is found in the deciduous and semi-evergreen forests of Western Ghats, India. It is commonly known as suran in Hindi. chunukoli in Urdu, badara in Sanskrit, and toran in Marathi. Z. rugosa is traditionally used in the treatment of skin diseases, mouth ulcers, dropsy, boils, diarrhea, tachycardia, syphilis, miscarriage, misconception, flatulence, hysteria, And as astringent. It has been investigated foranti-diabetic, anti-inflammatory, α-glucosidase inhibitory, cytotoxic, antioxidant, antibacterial, anthelmintic, analgesic, and insecticidal activities. It is reported to contain diverse classes of secondary metabolites like alkaloids, flavonoids, glycosides, saponins, triterpenoids, tannins and phenolics. Several constituents are reported from different parts of this plant cyclopeptide alkaloids (rugosanin-A, amphibine-D, rugosanin-B, sativanin-H, nummularine-P), pentacyclic triterpenoids (2-α-hydroxyursolic acid, oleanalic acid, alphitolic acid, betulinaldehyde, betulin, betulinic acid, lupeol), flavonoids (kaempferol, quercetin, myricetin, apigenin, apigenin-7-o-glucoside, kaempferol-4-methylether, kaempferol-3-o-rhamnoside, luteolin, luteolin -7-o-glucoside), dihydroxy benzoic acid (vanilic acid), quinoline (isoquinoline). The present review is an attempt to connect the traditional use of Z. rugosa to its phytochemistry and pharmacology, thereby opening up new avenues in...
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Posted by admin on Mar 31, 2022 in |
In recent times, the use of radiopharmaceuticals in Medical Imaging and Nuclear medicine has increased. They are a special group of pharmaceuticals with short-shelf life in their final state, and their preparation has been done with utmost care. Due to the inherently hazardous nature of radionuclides on the one hand and the associated concern about radiation safety for patients and staff handling them on the other, this necessitates extreme caution during their manufacture, dispensing, storage and disposal. Therefore there is a need for the implementation of the regulatory guidelines to improvise the quality, safety, and potency of radiopharmaceuticals. This review mainly highlighted the regulatory framework for handling, disposal, and clinical trials of radiopharmaceuticals according to India, Europe Union and USA guidelines. However, in India Cosmetic and Drug act 1940 and rules govern the pharmaceutical industries for the regulatory framework and in Europe and the USA, they follow the EANM and USFDA guidelines. This guideline helps to improvise and remove the barrier for submission to regulatory authorities. The review article...
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Posted by admin on Mar 31, 2022 in |
The essential part of robots in the medical services framework is principal limiting individual to individual contact defilement and guaranteeing cleaning disinfection. Robots can be defined as an artificially intelligent physical systems capable of interrelating with the environment. The term robot was coined from the Czech what “robota” which implies serf/worker. Robots are classified as Receptionist robots, Surgical robots, Ambulance robots, Service robots, Telemedicine robots. During this pandemic, these mechanical frameworks can diminish the danger of irresistible illness transmission among forefront medical services laborers and afterward make it a potential advance to assess, accentuate, screen, and treat the patients from a safe distance, accordingly bringing down the responsibility of medical care staff. Robots are all around planned with UV light to sanitize the rooms and even themselves. Teleoperated robots in the medical care framework turn into the laborers’ eyes, ears, and bodies in the Isolation Ward, which might be dependable during this COVID-19 pandemic. This mechanical innovation will assume a vital part during this basic stage in certain spaces...
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Posted by admin on Mar 31, 2022 in |
A progressive neurodegenerative brain disorder with motor & non-motor are signs of Parkinson’s disease or idiopathic parkinsonism. Parkinsonism is characterized in striatal region by the deterioration of Substantia nigra pars compacta & dopamine depletion in Dopaminergic neurons. In Parkinsonism research, the prime purpose is to recognize the pathogenesis, strategies & implementation of therapeutic frameworks that regulate the disease progress. Versions of toxins are even starting to be used to anticipate what might arise in individual Parkinson’s disease. There is indeed, ton of advancement to be developed especially with reference to the design of experimental models which can precisely determine productive clinical neuroprotective substances. For Parkinsonism research, modern pharmacological, neurotoxin-induced, genetically altered & cellular models become presently accessible. Although caution should be exercised in the initial detection of neurodegenerative illnesses, data imply that future progress is secure, possible and probable to boost clinical care. In this overview, comprehensive information on key features of in-vivo & in-vitro models presently available has been...
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Posted by admin on Mar 31, 2022 in |
Prunus amygdalus Batsch (family-Rosaceae), popularly known as Badam, Almond, is the most important familiar nuttree for global nut production that includes apples pears, prunes and raspberries. Almond seed skin is a prominent source of polyphenolic compounds, mainly phenolic acids, bioflavonoids, flavanones, isoflavones, flavonol glycosides and lignans that are reported in a ripened nut. Bioflavonoids such as flavanolglycosides, chieflycatechins, epicatechin, procyanidins and flavonol include 3-hydroxyflavone backbone glycosides, particularly isorhamnetin, isorhamnetin, naringenin and kaempferol are novel agents isolated from ripened seeds. The review aims to renew the interest in this promising plant, thus stimulating researchers to go further with the study for discovering novel medicinal agents for the treatment and management of several kinds of ailments. The present study compiled a detailed and unique summary of traditional folk medicine Prunus amygdalus based on screening the various databases from traditional textbooks, Science Direct, Google Scholar, PubMed, Elsevier, Springer Nature, and Research Gate, etc. The kernels of the seeds are a major source of vitamin E and B, dietary fiber, essential elements calcium and...
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