Posted by admin on Dec 31, 2021 in |
Euphorbia hirta Linn. (Euphorbiaceae), commonly known as ‘Dudhy’ is an annual medicinal herb of Kumaun Himalaya Uttarakhand. It is an invasive plant used in conventional medicine to treat various diseases such as gastrointestinal disorders, respiratory system disorders, and asthma. The present review is designed with the aim to compile updated information on E. hirta including its medicinal uses, phytochemicals, as well as biological activities. Qualitative and quantitative phytochemical studies on E. hirta revealed the presence of various chemical compounds in which flavonoids, terpenoids and phenols are the major constituents. These monomeric compounds and crude extracts from E. hirta have also been screened for pharmacological activities in-vivo and in-vitro. Different parts of the plant have interesting antimicrobial, antioxidant, antidiabetic, and antitumor properties. Some traditional uses of this plant, such as in gastrointestinal disorder, bronchitis, and in asthma, also indicated its high medicinal potentiality. E. hirta has been proved a valuable medicinal plant for the tribal people living in the rural region of Kumaun Himalaya. The crude hydro-alcoholic extract of E....
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Posted by admin on Dec 31, 2021 in |
An extensive range of studies have shown plant extracts and their phyto-constituents efficacy, proposing them as a promising alternative for treatment or as adjuvants in human diseases such in skin, gastrointestinal, systemic and dental conditions, due to various active components presence, ease of access and reduced side effects. Indeed, depending on solvent used to obtain the extract, its active molecules may vary, including flavonoids, tannins, alkaloids, terpenes, sesquiterpenes, sterols, among others. Extract content (crude/partition/fraction) has pharmacological advantages over isolated compounds, due to pleiotropic activity and synergistic effect between components. Due to factors such as low bioavailability, solubility, and stability, it is difficult to translate its in-vitro and in-vivo effects into clinical picture, besides that pharmacological effects full potential cannot be exploited. However, in recent decades, extraordinary advances have been made in new drug delivery systems for the encapsulation of active plant metabolites, thus helping to improve different medicinal plant-based therapies and product efficacy. The current review highlights the importance of nanocarriers loaded with plant extracts as an alternative for dental, dermatological, gastrointestinal,...
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Posted by admin on Nov 30, 2021 in |
Psoriasis is a chronic inflammatory skin disease characterized by red, scaly and raised patches, and it has affected nearly 2-3% of the population worldwide. This skin disorder occurs when the immune system sends faulty signals that result in the speeding up of the skin cell cycle. Psoriasis is histologically characterized by marked hyperproliferation of keratinocytes, neutrophils, and a dense inflammatory infiltrate of T cells. Vascular dilation and proliferation are also observed. The primary defect in psoriasis patients was believed to be an abnormal epidermal cell proliferation. Psoriatic skin exhibits an advanced state of lipid peroxidation. It has been suggested that antioxidant treatment can help in the management of the disorder. Literature indicates that polyphenolic compounds found in plants have a positive effect on many chronic diseases. Natural polyphenols, recognized as potent antioxidants, are multi-functional molecules that can act as anti-inflammatory and antiproliferative agents through the modulation of multiple signalling pathways. This characteristic could be advantageous for the treatment of multi-causal diseases, such as psoriasis. Genistein is one of such...
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Posted by admin on Nov 30, 2021 in |
Oral administration of drugs is considered a convenient route; however, various drugs that are insoluble in water or cannot permeate across gastrointestinal tract membrane cannot be delivered by this route. To enhance the permeability through the physiological barriers, lipophilic drugs are introduced but, lipophilic drugs have low oral bioavailability. To enhance the bioavailability, a third-generation lipid matrix was introduced as nanostructured lipid carriers (NLCs), which are a mixture of solid lipids mixed with some incompatible liquid-lipids. NLCs have been reported to be an alternative system to emulsions, liposomes, microparticles, solid-lipid nanoparticles (SLNs). This article mainly focuses on the types and methods of preparation, advantages, the applicability of NLCs in the present and in the near...
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Posted by admin on Nov 30, 2021 in |
Male infertility has remained a complex multi-factorial disease and needs advanced molecular studies. The development of effective diagnostic capabilities has resulted in the desire to create minimally invasive tests to help in the understanding of the etiology of male infertility. In recent times, research on human sperm proteomics has gained momentum and provides detailed information regarding spermatozoa’s functional state. Sperm proteome changes are seen in many male infertility cases linked conditions. A Revolution in omics and the availability of advanced proteomic tools have increased the knowledge and understanding of the causes of male infertility. Proteomic tools and techniques including liquid chromatography, mass spectroscopy and MALDI-TOF are employed in sperm proteins profiling towards identifying the molecular pathways that are defective in infertile men. Proteomic information empowers better comprehension of sperm biochemistry and provides data that aids in improving reproductive outcomes in infertility patients. Therefore, this review explores the proteomic concepts and techniques for spermatozoa proteome analysis. It also examines the proteomic approaches, including the role of sperm proteomic data, in...
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