Posted by admin on Nov 30, 2021 in |
Background: In the field of pediatrics, a number of herbo-metallic preparations are available which tend to enhance immunity in children. Various Ayurveda texts have mentioned these preparations, especially gold formulations like Swarna Prashan, Suvarnabindu, Suvarna Vacha, Kumarabharana Rasa etc. in children, and many clinical studies have also been published to establish their safety and efficacy. Material and Method: Subject-related published research articles from various journals were searched online through PubMed, Google Scholar and data of the articles were analyzed by following PICOS format to confirm their safety and efficacy in the paediatric population. Results: Total 7 clinical studies showing safety and efficacy of Ayurvedic herbo-metallic preparations in paediatric disorders such as Chronic tonsillitis, Upper Respiratory Tract Infection (URTI) and healthy children were treated with significant effect in their diseased condition and reducing the frequency of recurrent infections. No any adverse or toxic effect of any of these formulations was noticed. Conclusion: Gold preparations are found quite safe to use in pediatric disorders with proper dose and vehicle as well...
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Posted by admin on Nov 30, 2021 in |
Medicinal plants are a reservoir of biologically active compounds with therapeutic properties, and in that context, Opuntia ficus indica and other Opuntia species are of immense importance because of their nutraceutical and pharmaceutical values along with their anti-inflammatory effects, hypoglycemic, anti-hyperlipidemic effects, anti-atherogenic and anti-spermatogenic potential. The cactus Opuntia is a xerophytic plant grown in more than thirty countries, including Mexico, South America, South Africa and India. All parts of the plant, including pear, roots, cladodes, seeds and juice, have these pharmacological properties, which have been attributed to the presence of high content of phenolic acids, flavonoids such as quercetin, kaempferol, anthocyanin and ascorbate etc., and pigments such as carotenoids, betalains, tannins etc. Other reported phytochemical components such as biopeptides, phytoalbumins, minerals such as vitamin B1, B2, B3 and Vitamin C, soluble fibers also add to the medicinal properties of Opuntia spp. presence of these bioactive has made Opuntia a high potential plant that can be investigated for commercial production and consumption as a neutraceutical. The present review provides...
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Posted by admin on Nov 30, 2021 in |
Neurodegenerative diseases are progressive degeneration of certain nerve cells causing ataxias and dementia affecting millions of people worldwide. Transdermal drug delivery systems – “patches” represent an attractive alternative to the conventional method and have made an important contribution to the management of the various medical conditions. A transdermal patch is a medicated adhesive patch which delivers drug via skin to the systemic circulation in a controlled manner. The advancement of various sophisticated transdermal delivery technologies led to of increase in the number of approved drugs. This route of administration has several innate and major advantages that have the potential to benefit various patient populations, including those with nervous system disorders. The transdermal route is an ideal route for the management of chronic neurological conditions as they are capable of providing continued drug delivery and maintaining steadier plasma concentration of drugs thereby reducing adverse events. Moreover, a transdermal patch is convenient, efficient in enhancing medication therapy and patient compliance. This article reviews the rationale and scope of the transdermal route...
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Posted by admin on Nov 30, 2021 in |
Upper respiratory tract infections are the major cause of childhood morbidity leading to limit the day to day activities and school absenteeism. Diseases like tonsillitis, cough, and cold account for the maximum respiratory tract morbidities. Studies document that, in developing countries, on average, every child has five episodes of acute respiratory infections per year accounting for 30%-50% of the total pediatric outpatient visits and 20%-30% of the pediatric admissions. Ayurveda states that in children, the Prana, Dosha, Dhatu, Bala, Ojas are under developed, and therefore, they are the most vulnerable group in terms of illness. Therefore they should be supported externally to potentiate their immune system. Good immunity has a substantial role in sustaining the body and preventing various infections. Although available conventional management provides symptomatic relief, there is no conclusive evidence that they shorten the duration of symptoms. The use of antibiotic is also not empirical. Therefore it is the need of hour to find some alternative to provide relief in symptoms, potentiate the immune system to resist...
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Posted by admin on Nov 30, 2021 in |
Azetidinones (Azetidin-2-ones), more commonly known as β-lactams, are well-known heterocyclic moieties among the medicinal compounds mainly because of their diverse pharmacological activities such as antimicrobial, anti-inflammatory, anticonvulsant, anti-HIV, anti-parkinsonian, antidiabetic and antitubercular activities. Various com-parative studies of current azetidinone derivatives show an alarming increase in the bacterial resistance to the β-lactam nucleus may be due to irrational usage, which unfortunately led to less therapeutic usage. Hence new hybrids of Azetidinones with other drugs containing different heterocyclic rings found to possess broad-spectrum efficacy against various types of bacteria with β-lactamase inhibition to find great scope for future needs. This concept of hybrid molecules of different heterocyclic drugs would be a cost-effective and time-saving experiment in the process of drug discovery and development. In today’s world of diseases and expensive drugs which are not affordable for countries like India, this attempt would be noon. Hence this review is an attempt to focus on the possible hybrid molecules of Azetidinones with other heterocyclic drugs for various...
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