Posted by admin on Feb 28, 2022 in |
Tissue specificity is the essential need of the hour to cut down clinical abnormalities. Allowing desired drug concentration to reach the target site is the current trend of the drug delivery system. Laminin is an active component of the basal lamina and present in most cells and organs has shown great utility in this case. It is a heterotrimeric glycoprotein containing an α-chain, a β-chain, and a γ-chain and found in different isoforms. Laminin influences cell differentiation, migration, adhesion, neurite outgrowth, and angiogenesis. The active peptides screened from the whole-length laminin have been incorporated to develop targeted or tissue-specific approaches. This is because full-length laminin has many active sites and triggers various downstream signaling and functions. Laminin-derived peptides along with various carriers or vectors ensure specific binding to target tissues. The particular therapeutic or diagnostic agent is successfully targeted to the diseased site because of the affinity of peptide sequence towards the cell membrane receptors. Promising applications of laminin-derived peptides are observed in diagnostics, therapy, chemotherapy, and gene therapy....
Read More
Posted by admin on Feb 28, 2022 in |
Tyrosine kinase inhibitors generally having a narrow therapeutic window and large inter-patient variability. In order to support its therapeutic drug monitoring, fast and accurate methods are needed to supporting the pharmacokinetic-guided dosing in patients treating with various tyrosine kinase inhibitors (TKIs) either alone or in combination in bulk, formulations or human plasma using HPLC and detection with tandem mass spectrometry (HPLC-MS/MS), gas chromatography with mass spectrometry, spectrofluorimetry and UV-Visible spectrometry. Literature suggested that the methods developed and validated are good for accuracy, precision, and assay for all TKIs studied. These methods are also applied for routine therapeutic drug monitoring and investigator-initiated research. In this review, we described different analytical methods used for the qualitative and quantitative estimation of all TKIs investigated till 2020 in assessing the quality of drugs by using HPLC, LC-MS, HPTLC, UPLC, UV-Visible spectrophotometry, spectrofluorimetry with a huge survey from the research articles published in various pharmaceutical and analytical chemistry journals. From this assessment, these methods were found to be superior based on the quantitative analysis...
Read More
Posted by admin on Feb 28, 2022 in |
Arbuscular mycorrhizal fungi (AMF) enjoy being the cynosure in most agro-ecosystems. These fungi benefit the plant in multiple ways. They improve plant growth by enhancing nutrient uptake and protecting the plant from various plant pathogens, thereby promoting plant diversity. These fungi improve plant tolerance to various abiotic stresses, such as salinity, drought, extreme temperatures, and heavy metals. They also provide aid in improving soil aggregation and soil stabilization, resultantly leaving a positive impact on ecosystem structure. The diversity of AMF varies among different habitats of the globe. The study of dynamics in the variety of these fungi in other host species in accordance with seasonal changes in a particular agro-climatic zone is significant to evaluate the natural status of these fungi in a specific region. It also becomes necessary to explore these fungal communities in different habitats for efficient utilization and conservation. The exploration of predominant AMF is also helpful in forming inoculums and its utilization for the production of better seedlings and their survival in adverse...
Read More
Posted by admin on Feb 28, 2022 in |
In this review, we are completely discussing different eras in pharmaceutical drugs/medicines, i.e., Biologics and biosimilars. These biologics can be called life drugs because they are deriving from living organisms, microbes, yeast, bacteria, and human blood products. These biologics are biopharmaceutical products that are derived from living organisms and are very complex in molecular structure, and do have very high molecular weight. The synthesis of these biologics is completely different from the small molecule drugs that are chemically synthesized. These biologics are synthesized by recombinant DNA technology. As these biologics are patented, they won’t allow the copying of these products. But they are now expiring their patents and leading their way to the development of their close copies, i.e., Biosimilars. Biosimilars are the copies of the biological which has to be proven as highly similar to that of their branded biologics for their efficacy and safety and has to be developed after the expiring of the patent term period of the biologics, like the generic drugs for the branded...
Read More
Posted by admin on Jan 31, 2022 in |
Rutin or quercetin-3-O-rutinose (C27H30O16) is an essential member of the flavonoid family, a classification of total components of plant phenolic compounds. Rutin is typically located in buck herb seeds. Broccoli fruits, especially citrus fruits, red apples, and berries and drinks such as beer, tea, and coffee. This bioflavonoid is accountable for imparting color and flavor to fruits and vegetables. Rutin is located in many other plants, such as participants of the Fagopyrum genera, F tataricum, usually regarded as tartarine buckwheat, is specifically prosperous in protein. It works as a coloring agent, meal, additive, and used in cosmetics. Also, rutin has a more potent therapeutic effect than other flavonoid derivatives and therefore it is used as a medication to deal with vascular diseases. Several metals such as mercury, aluminum, titanium, vanadium and nickel can be determined spectroscopically by rutin. Rutin incorporates a broad range of pharmacological properties. Traditionally, it is used as anti-microbial, anti-fungal, and anti-allergic agents. However, the contemporary study proved its multi-spectrum pharmacological benefits for treating several chronic...
Read More
