Posted by admin on Nov 30, 2021 in |
Euphorbia hirta Linn. (Euphorbiaceae), commonly known as ‘Dudhy’ is an annual medicinal herb of Kumaun Himalaya Uttarakhand. It is an invasive plant used in conventional medicine to treat various diseases such as gastrointestinal disorders, respiratory system disorders, and asthma. The present review is designed to compile updated information on E. hirta, including its medicinal uses, phytochemicals, as well as biological activities. Qualitative and quantitative phytochemical studies on E. hirta revealed the presence of various chemical compounds in which flavonoids, terpenoids, and phenols are the major constituents. These monomeric compounds and crude extracts from E. hirta have also been screened for pharmacological activities in-vivo and in-vitro. Different parts of the plant have interesting antimicrobial, antioxidant, antidiabetic, and antitumor properties. Some traditional uses of this plant, such as in gastrointestinal disorders, bronchitis, and asthma, also indicated its high medicinal potentiality. E. hirta has been proved a valuable medicinal plant for the tribal people living in the rural region of Kumaun Himalaya. The crude hydroalcoholic extract of E. hirta has more pharmacological...
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Posted by admin on Nov 30, 2021 in |
Ticagrelor is a platelet aggregation inhibitor. It is used for the prevention of stroke, heart attack, and other events in people with the acute coronary syndrome, meaning problems with the blood supply in the coronary arteries. It acts as a platelet aggregation inhibitor by antagonising the P2Y 12 receptor. Its half-life is up to 12 h with the hepatic type of metabolism and biliary excretion. This review provides the pharmacokinetic and pharmacodynamics of the Ticagrelor, which also includes the review on pharmaceutical analytical techniques like High-performance liquid chromatography, Reverse phase – High-performance liquid chromatography, Bio-analytical techniques, UV spectrometry with the impurities, pharmaceutical dosage forms, bulk, and its formulations used for determination and validation. This review helps us to get updated information on validation of drug-Ticagrelor till current...
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Posted by admin on Nov 30, 2021 in |
The excavation for new delegates into the chemotherapeutic family and modernization of existing candidates are evergreen goals of cancer researchers. It is quite interesting to make out that the plant kingdom has gifted us with an array of anti-cancer compounds, reporting over 60% of the drugs today coming out from natural sources such as plants, marine organisms, and micro-organisms. With the evolution of modern analytical tools, the chemical composition of active principle in each of the plant parts is being elucidated, and more plants are being analyzed for their pharmacological application and nominated to the list of medicinal plants. Members of the Verbenaceae family, such as Clerodendrum infortunatum crowns in medicinal values tricked with a worthless treasure of phytochemical constituents, many of which remain mysterious. This paper reviews the different aspects of Clerodendrum infortunatum concerning its phytochemical constitution, traditional usage, and potential possibilities in the treatment and prevention of cancer. The source materials were browsed from Pubmed and Google by word search for Verbenaceae, Clerodendrum, Cancer, etc. Clerodendrum infortunatum,...
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Posted by admin on Nov 30, 2021 in |
In spite of huge investigations, the pathology of Alzheimer’ sdisease (AD) is uncertain. Vessels dysfunction is a critical mark of AD. Research has stated like beta-amyloid (Aβ) results augmented vascular development in brains, a pathway observed in AD patients. In AD, cerebral endothelium releases pro substances for β-amyloid plaque and neurotoxins that kill cortical neurons. Vascular vulnerable features and neural, vascular dysfunction related through hypo or hypertension, hypercholesterolemia, diabetes mellitus, smoking, oxidative stress, and iron overload have been invented to play essential parts in the pathogenesis of stroke and AD. Antiangiogenic agents and small molecule kinase blockers are being examined and approved for anticancer therapy and showed normal blood vessel growth in the affected areas. Endothelial cells (EC) are triggered by the angiogenesis of cerebral ischemia and hypoxia. Outcomes of epidemiological research show that chronic administration of NSAIDs, statins, H2 antihistamines, or calcium-channel blocker sappearstoavert AD. This is mainly due to the ability of the drugs to prevent angiogenesis. Many previous reviews on pathogenesis on AD have explained neuronal...
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Posted by admin on Nov 30, 2021 in |
Beta-blockers are widely used in combination with Ivabradine in people with coronary heart disease (CHD), one of the leading causes of death. Thus, monitoring of these drugs is important because it is accessible to manage heart failure amongst people with CHD. In addition, its quality control is fundamental to provide quality medicines. Method of analysis can be the first step in the rational use of pharmaceuticals. In this context, a detailed study of literature and official compendia for the pharmaceutical quality control of Ivabradine and Metoprolol were done. Among the analytical methods in the evaluation of Ivabradine and Metoprolol, HPLC is predominantly followed by HPTLC and UV. It was found that in the literature that analysis of Ivabradine and Metoprolol-based pharmaceutical products are more common than analysis of Ivabradine and Metoprolol in biological matrices. Pharmaceutical analyses have an impact on analytical decisions as well as effective and reliable results. The method must be suitable for the intended investigation. Although, there is a lack of Analytical Methods for estimation of...
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