Posted by admin on Nov 30, 2021 in |
The earliest anecdotes of ‘medical device’ dates back thousands of years. In 7000 BC, Neolithics used flint-tipped drills and bowstrings for dentistry. However, regulation of medical devices has only happened recently. Modern medical devices are used for the diagnosis, cure, mitigation, treatment, or prevention of disease. This industry is one of the most dynamic, disruptive, and fastest-growing among all segments in healthcare. However, there are challenges. The transition from innovation to patient care and eventually financial success has proven to be the Achilles hill for most organizations attempting to create a niche within the industry. There has been a multitude of problems to deal with. Financial, operational, technological, and regulatory issues have been plaguing the industry for years. Thankfully, with the advent of new-age technologies like artificial intelligence and machine learning, we are witnessing a paradigm shift in this space. In this review article, we delve deep into the history, evolution, and challenges in the medical devices space. We also look at the emerging technologies that are shaping the...
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Posted by admin on Nov 30, 2021 in |
Mucormycosis is an opportunistic fungal infection caused by a member of the order Mucorales. It is an angio-invasive fungal infection because of its propensity to invade blood vessel walls, resulting in catastrophic tissue ischemia (restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism), infarct (tissue death that is necrosis) due to inadequate blood supply to the affected area. Mucorales fungi are distributed worldwide and found in soil and decaying organic substrates. The most common microbiologically confirmed infecting members of the order Mucorales are Rhizopus, Mucor, Cunninghamella bertholletiae, Apophysomyces elegans, Absidia, Saksenaea and Rhizomucor pusillus. The incidence of mucormycosis has increased significantly in patients with diabetes which is the commonest underlying risk factor globally. Recently, COVID-19 caused by SARS CoV-2 has further worsened the incidence of this disease. Diagnosis of mucormycosis remains challenging. The clinical approach to diagnosis has a low sensitivity and specificity; however, it helps raise suspicion and prompt the initiation of laboratory testing. Histopathology, direct examination, and culture remain essential tools,...
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Posted by admin on Nov 30, 2021 in |
Pharmaceutical preparation mostly contains active ingredients and excipients. The function of excipients to improve the physicochemical properties of pharmaceutical manufacturing products. In pharmaceutical preparation, polymer plays a key role act as excipients in any dosage formulation development. Polymers are derived from the source of natural and synthetic. The polymer should have basic properties such as stable, biocompatible, non-toxic, economical, biodegradable, and hydrophilic and influence the release of the drug. For designing any pharmaceutical dosage form, the selection of polymer play a key role because due to polymer diversity. Natural polymers help in the improvement and control of the pharmacokinetics of the drug. In recent times, pharmaceutical manufacturing companies use a natural polymer to resolve the problem of side effects and drug release in sustained release formulation. The polymers which isolate naturally are mostly polysaccharides. Here in this review discussion of natural polymer source, solubility, chemical nature, and pharmaceutical application for novel drug...
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Posted by admin on Oct 31, 2021 in |
The field of nanotechnology is one of the notable active analysis areas in modern material science. Recent advances in Nanoscience and nanotechnology have led to the development of nanoparticles, which ultimately decrease potential health and environment hazards. Interest in developing environmentally friendly procedures for the synthesis of metallic nanoparticles has been increased. The purpose is to minimize the negative impact of synthetic procedures, their accompanying chemicals, and derivative compounds. Nanoparticles produced by green technology are more superior when compared to those manufactured with physical and chemical methods based on it eliminates the use of most expensive chemicals and also use less energy along with formation of environmental byproducts. In the synthesis of metallic nanoparticles, natural resources have been used. The exploitation of different biomaterials for the synthesis of nanoparticles is considered a valuable approach in green nanotechnology. This review provides an overview of the mechanisms of green synthesis of metallic nanoparticles and their...
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Posted by admin on Oct 31, 2021 in |
Oral cancer is one of the lethal cancers, having first rank in India and sixth most deadly cancer in world and most of the time occurs due to improper lifestyle and adverse habits. Cancers of the lung, oral cavity, pharynx, larynx, esophagus, urinary bladder, renal, pelvic and pancreas are among the neoplastic diseases induced by smoking. Epidemiological studies have firmly identified the connection between smoking and oral cancer. In the review, we have discussed about the risk factor of oral cancer, recent advancement in treatment of oral cancer and cases in Karnataka state of India. We focused on the reason of oral cancer, as many studies suggested that tobacco (smokeless and smoking), excessive consumption of alcohol, and exposure of radiation are the main causing agents of oral cancer. People adopted tobacco socially in India and there is something to worry about that people are not aware that tobacco is primary causal factor of oral cancer. In present study, we focused on the treatment of oral cancer and what modification...
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