Posted by admin on Sep 30, 2025 in |
Tinospora cordifolia (TC), family Menispermaceae, a widely used herb in Ayurvedic formulations, is known for its therapeutic advantages in the treatment of fever, urinary problems, managing diabetes, metabolic disorders, dysentery, and enhancing immune function. However, its concurrent intake with commonly prescribed drugs raises alarms about potential herb-drug interactions. This review objectives to provide a guide to healthcare professionals (HCP) providing comprehensive knowledge of common pharmacokinetic and pharmacodynamic interactions of TC, focusing on its effects on cytochrome P450 (CYP) enzyme metabolisms, which is critical for the biotransformation of various commonly prescribed drugs. This review also highlighted the mechanism of interaction and clinical implications. By referring to this review, HCP can manage concurrent administration of TC and commonly prescribed medicines, ensuring education to the patient for their safety. Despite the frequent claims that herbal products are natural and safe, it is incorrect to undervalue clinically significant herb-drug interactions or ineffectiveness. Therefore, a careful clinical implication examination has been conducted to assess the effects of TC when used together with commonly prescribed...
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Posted by admin on Aug 31, 2025 in |
Invasomes, within the scope of transdermal medication delivery and cosmetic formulations, nowadays have emerged as impressive technology and are described in comprehensive detail in this review paper. Essentially, invasomes are built from a unique substance, techniques, and processes that can enable active compounds to penetrate easier into the skin than standard liposomes, with the help of phospholipids, ethanol, and terpenes while remaining within the skin boundaries and decreasing systemic absorption. This paper discusses the advantages of invasomes over the conventional delivery systems, including enhanced bioavailability and targeted delivery of therapeutic agents. Other aspects discussed include advancements in nanotechnology and process automation to reduce the production cost and enhance the scalability without any compromise on quality. Review of applications of invasomes in dermo-cosmetic products focuses on their role in treating skin dysfunctions. In summary, it is underscored in this paper that invasomes can revolutionize skincare formulations and hence help overcome multiple dermatological...
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Posted by admin on Aug 31, 2025 in |
It is leukaemia, where immature white blood cells keep growing at a very fast pace and disrupt normal blood production. While there are many advances in treatment, genetics diversity, drug resistant and technological limits remain. Likewise, such AI combined with multi dimension approaches (genetics, transcriptomics, proteomics, metabolism, and epigenetics) has altered leukaemia research. Divining the diagnosis, risk assessment and precise plan for effective treatment from vast amounts of data allowed by AI is possible. In addition, it shortens the time of diagnosis, predicts responses to therapy, and explains how it fails. By integrating AI into mitigation of CML, tyrosine kinase inhibitor is first identified and targeted therapy is guided by other key biomarkers. Same is the case for AML which is mitigated by CK inhibitors and FLT3 inhibitors. Interruption and identification of various pathways by metabolomics and proteomics provide new therapeutic targets. More and more clinical studies show that AI assisted multi-omics strategies add value in making personalized care, reducing relapse, and increasing survival. Since challenges such as data...
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Posted by admin on Aug 31, 2025 in |
Cancer remains a major cause of mortality worldwide, with chemotherapy serving as a cornerstone of cancer treatment. While effective in targeting malignant cells, chemotherapy is associated with debilitating side effects, including cachexia a complex, multifactorial syndrome characterized by unintentional weight loss, muscle wasting, fatigue, and reduced physical function. This condition arises from cancer progression and chemotherapy-induced toxicity, compounded by systemic inflammation, oxidative stress, and mitochondrial dysfunction. Chemotherapy agents trigger the release of pro-inflammatory cytokines, promote the generation of reactive oxygen species, and activate the ubiquitin-proteasome system, all of which contribute to skeletal muscle atrophy. The resulting impairment in physical function, diminished treatment tolerance, and worsened prognosis significantly impact patient outcomes. Unlike general cancer-associated muscle wasting, chemotherapy-induced cachexia involves unique mechanisms, including the activation of nuclear factor kappa beta and mitogen-activated protein kinase pathways by agents such as Cisplatin. Cachexia is further aggravated by side effects such as reduced appetite, nausea, and fatigue, leading to myosteatosis and deterioration in muscle mass and function. Current therapeutic approaches include pharmacological agents such...
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Posted by admin on Aug 31, 2025 in |
The prevalence of psychiatric disorders in AUD, the association between the severity of AUD and psychiatric disease, the influence of treatment of AUD on relief of psychiatric symptoms and vice-versa has been studied in various parts of the world. In India, the influence of various socio-economic factors and the lifestyle of the individuals is different to other parts of the world. There is paucity of the literature regarding the association of AUD with psychiatric disease, influence of AUD on pharmacotherapy of psychiatric disorders, the quality of life of patients with co-existing AUD and psychiatric disorders. This review aims to study the association and co-occurrence of AUD and psychiatric disorders and influence of combined disorders on the...
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