Posted by admin on Oct 31, 2021 in |
Since ancient times, humans have always been captivated by nature and have explored natural products. To combat against novel emerging and reemerging diseases and tremendous side effects imposed by recent therapies, scientists have again taken an interest in natural resources. To date, plants have been the major source of natural bioactive compounds, but recently fungi have got more attention. Amongst fungi, edible and medicinal mushrooms have come out as a rich source of bioactive metabolites. Since long back, they are being consumed heavily because of their outstanding flavour, aroma, nutritional value, and medicinal properties. Both edible, as well as medicinal mushrooms, synthesize bioactive compounds known as secondary metabolites i.e., polysaccharides, steroids, terpenes as well as peptides. Such metabolites possess many medicinal properties like anti-oxidant, anti-tumor, anti-diabetic, anti-cancer, anti-ageing, and also anti-obesity. Furthermore, mushroom secondary metabolites are prioritized over other natural compounds due to their non-toxic nature and low or no side effects. This review mainly covers sources and types of secondary mushroom metabolites and their therapeutic...
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Posted by admin on Oct 31, 2021 in |
Peripheral neuropathy refers to many conditions that involve damage to the peripheral nervous system. In this article, we would like to discuss various aetiological factors and their manifestations, pathophysiology, diagnosis and treatment strategies of peripheral neuropathy. Generally, peripheral neuropathy is caused by many underlying disease conditions such as Diabetes mellitus, Shingles (postherpetic neuralgia), Vitamin B-12 deficiency, Alcoholism, Autoimmune disorders (Rheumatoid arthritis, Systemic lupus erythromatosus), Lyme disease, Syphilis, HIV, Exposure to toxins (lead), chemotherapies and Hereditary disorders such as Charcot-marie-tooth. The clinical presentations of peripheral neuropathy generally involve pain, burning or tingling sensations in the distribution of the affected nerves mostly in the hands and feet. The diagnosis of PN includes a physical examination, blood tests, a keen study of medical history, family history and lifestyle of the subject. Patients with peripheral neuropathy typically do not respond to traditional analgesics (paracetmol, NSAIDs) or weak opioids because these do not focus on treating various types of symptoms of PN. However, some Antidepressants, Serotonin or epinephrine reuptake inhibitors (SNRIs), Topical therapies and...
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Posted by admin on Sep 30, 2021 in |
Background: Hepatocellular carcinoma (HCC) represents the third most common cause of death in the world. It is resistant to most chemotherapeutics and associated with a poor prognosis. Unani system of medicine offers effective treatment for various chronic liver diseases. These treatments have shown reversal of inflammation and fibrosis in various clinical conditions. In the present study, we have reviewed Unani formulations to identify plant drugs that are valuable for the development of novel and effective drugs in management of HCC. Method: PubMed and Google Scholar were searched using mesh terms ‘hepatocellular carcinoma’; ‘liver diseases’ ‘name of individual Unani formulation and plant drug’. The outcome of interest included formulations used for liver diseases; phytochemical and pharmacological information of individual plant drugs. The additional information sources were the National Formulary of Unani Medicine and Unani Pharmacopoeia of India (Formulation). The outcome of interest was the composition and applications of formulations prescribed for liver diseases. Result: Total of 710 unique formulations were searched, out of which 59 formulations having hepato-protective, hepatotonic, deobstruents,...
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Posted by admin on Sep 30, 2021 in |
Green synthesized gold nanoparticle is one of the most promising drug delivery approaches with biocompatibility and biodiversity. Various plant sources such as Aegle marmelos, Eugenia jambolana, Soursop, Persea Americana, Terminalia chebula, Aloe arborescens, Musa paradisiacal, Alternanthera philoxeroides, Cissus quadrangularis, Sterculia acuminate, Garciniaindica choissy, Eucalyptus globulus, Rosmarinus officinalis, Punica granatum, Pistacia atlantica, Pistacia integerrima, Juglans regia, Curcumae kwangsiensis; fungal sources as Pleurotus cornucopiae var. citrinopileatus, Cladosporium cladosporioides; other microbial sources as Magnusiomyces ingens LH-F1, Micrococcus yunnanensis, Padina tetrastromatica are used to develop biocompatible gold nanoparticle with veritable diversified particle size and applicability profile as anticancer (especially against breast cancer, liver cancer, ovarian cancer and lung cancer), antibacterial agent, photo luminescent, heavy metal sensor, etc. If biogenic sources are composed of a large number of hydroxyl and carboxylic acid groups, it can behave as reducing agents to develop gold nanoparticles with immense biomedical and pharmaceutical applications. This novel approach and data are very much encouraging and may be considered as one platform for searching all the important green synthesized gold nanoparticles...
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Posted by admin on Sep 30, 2021 in |
Isatin, a heterocyclic moiety, is a significant scaffold in medicinal chemistry. Isatin contains a nitrogen atom at position 1 and two ketone groups at positions 2 and 3. It consists of two cyclic rings, one of which is a six-membered ring, and the other is a five-membered ring. It is a resourceful nucleus for the synthesis of several pharmacologically active molecules. Isatin itself acquires an extensive range of biological activities. Currently, the design of unique isatin derivatives as potent drugs is the key role of the researchers. The focus of this present study is to overview the recent literature published on isatin derivatives. In this review, some of the pharmacological activities of isatin derivatives such as anticancer, antibacterial, antiviral, antifungal, antioxidant, antitubercular, anti-malarial, antidiabetic, anticonvulsant, analgesic, and anti-inflammatory activities were reported. From these studies, isatin has been established as the more promising candidate for further research and investigations in many...
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