Posted by admin on Apr 30, 2025 in |
Introduction: The space environment induces distinct modifications in astronaut physiology that necessitate the attention of medical professionals and researchers. These alterations stem from various space related factors including radiation, disrupted sleep-wake cycles and notably the absence of Earth’s gravitational pull, which has traditionally been crucial for establishing normal bodily functions and balance. It has been noted that exposure to microgravity leads to a dysregulated human immune system at the cellular level, potentially posing health risks for astronauts. Methods: The completion of this study involved consolidating information from classical Ayurvedic literatures, academic research papers, guidelines, as well as searching databases such as PubMed and MedLine. Results and Discussion: Radioprotective agents encompass substances such as antioxidants and similar compounds containing sulfhydryl groups along with adaptogens, are agents that enhance resistance to radiation. Typically derived from natural sources, these biological protectors defend against mild ionizing radiation by regulating immune responses and enhancing the body’s own antioxidant mechanisms, thus enhancing overall resistance in biological systems. Ayurvedic medicinal plants exhibit a promising ability to...
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Posted by admin on Apr 30, 2025 in |
This review paper provides a comprehensive overview of the role of machine learning (ML) in drug discovery and development within the pharmaceutical industry. It begins by outlining the foundational concepts of machine learning, highlighting its ability to enhance decision-making and improve accuracy through data analysis. The paper emphasizes the growing adoption of ML techniques across the pharmaceutical sector, showcasing their potential to streamline drug discovery processes, reduce costs, and minimize reliance on animal testing. It categorizes various machine learning methods, such as supervised, unsupervised, semi-supervised, and reinforcement learning, and discusses their applications in drug discovery, including predicting drug efficacy, optimizing lead compounds, and validating safety biomarkers. Furthermore, the paper delves into advanced ML techniques like transfer learning, multitask learning, and active learning, which address challenges related to data scarcity and enhance model performance. The discussion also covers specific algorithms such as Support Vector Machines, Decision Trees, and Artificial Neural Networks, illustrating their utility in predicting biological properties and improving drug design. Ultimately, the paper concludes that the integration of...
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Posted by admin on Apr 30, 2025 in |
The kidney is an important organ in waste filtration, plays a central role in maintaining body homeostasis. The management of kidney stones includes several techniques over the period of time which involve Percutaneous Nephrolithotomy (PCNL), Shock wave lithotripsy (SWL) and Ureteroscopy (URS). Ureteroscopy has undergone considerable innovations over the last few decades. Laser technologies have further advancement for kidney stone removal that is Holmium fiber laser technique and thulium fiber laser technique. Holmium laser technique removes the stone by dusting and fragmenting it. The selection of technique depends on stone type, size and location. Thulium fiber laser has higher precision and efficiency due to its shorter wavelengths and continuous-wave emission characteristic. These technological advancements have resulted in more positive patient outcomes due to reduction in recovery times and fewer complications. This review provides complete overview of the physiology of the kidney, composition of kidney stone, factors affecting on their formation and the management techniques with focusing on the development of ureteroscopy and the latest laser technologies for kidney stone...
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Posted by admin on Apr 30, 2025 in |
Several fast-dissolving drug delivery systems have been designed to address issues like accurate dosing in liquid dosage formulation (suspension, emulation, syrup etc.) and swelling problems in solid dosage form (capsule, Tablet etc.). To fill these gaps fast-dissolving drug delivery system have been designed to address these issues. Biggest advantage of having Oral thin Film is, it can be taken without water, Easy to tackle and carry. Oral thin film formulates with various polymers, plasticizers, active pharmaceutical ingredients, sweetening agents, flavoring agents, coloring agents, stabilizing saliva enhancing agents and thickening agents. The method of preparation for oral thin film were reported are solvent casting, Semisolid casting, Hot melt extrusion, Solid dispersion extrusion and rolling. The current evaluation gives an account of different formulations methods of preparation and quality control of the fast-dissolving oral thin film. Stable drug-type tablets and capsules are inconvenient to administered for many pediatric and geriatric...
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Posted by admin on Apr 30, 2025 in |
Haemangiomas are vascular lesions caused by abnormal blood vessel proliferation, especially in children. Kasabach-Merritt syndrome (KMS) is a rare and life-threatening thrombocytopenia and consumptive coagulopathy associated with aggressive vascular tumors in infancy and younger children. Kasabach-Merritt phenomena is a unique phenomenon in kaposiform hemangioendotheliomas (KHE) and tufted angiomas (TA), occurring in 70% of KHE cases and less often in TA instances. Risk factors for KMS include patient age under 6 months, lesion size greater than 5.0 cm, and the presence of a mixed lesion. Diagnosis of KMS is essential for preventing hemorrhagic complications and establishing a treatment plan. Physical examination, imaging, and biopsy are essential for identifying the underlying vascular tumors. Severe thrombocytopenia, a component of Kaposiform hemangiomas, is a potentially fatal side effect of vascular tumors in children. Treatment aims to manage thrombocytopenia and avoid lethal outcomes. According to SEOP (Spanish Society of Pediatric Oncology) guidelines for vascular tumors complicated by KMS, including vincristine, aspirin, and ticlopidine (VAT therapy). Corticosteroids are the most commonly used acute treatment for...
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