Posted by admin on Aug 31, 2021 in |
A Novel virus, coronavirus 2 (SARS-CoV-2), in 2019 from Wuhan, China which is globally expanded, causing the severe acute respiratory syndrome. Coronavirus is transmitted human to animal or human to human through airborne droplets. Coronavirus causes respiratory infections like pneumonia, cold, sneezing and coughing, while in animals, it causes diarrhoea and upper respiratory diseases. The virus outbreak has been declared a public health emergency of international concern by the World Health Organization (WHO), Since Covid -19 rapidly spread throughout the world from the Hunan seafood market at Wuhan, South China. The virus enters into the human cell through the membrane ACE-2 exopeptidase receptor. WHO and ECDC guided to stay away from a public place and close contact with contaminated individuals and pets. Coronavirus (2019-CoV), first and foremost, was isolated on 7th January 2020 at Wuhan market China. Here we have encapsulated the current clinical features data to guide budding Covid-19 about the Prevention, Diagnosis, Treatments and Prevention. Throughout the world, the disease has caused a range of degrees of...
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Posted by admin on Aug 31, 2021 in |
Microorganisms that live their life in places with high salt concentrations are known as Halophiles. Halophilic bacteria play a majority role in hypersaline environments than other microorganisms. These Halophiles are having intense strategies of adaptation and tolerate them to sustain their survival in the saline extreme, such adaptation in hypersaline environments makes them to give unique attention to the researcher for their biological properties. The diversity of halophiles bacteria incorporates aerobic and anaerobic phototrophs, aerobic heterotrophs, fermenters, denitrifies, sulfate reducers, and methanogens. The biotechnological important of the halophilic bacteria, such as producing a Novel bioactive compounds, industrially important enzyme, Bio-surfactants, Stabilizers Exopolysacharides, Probiotics etc. Secondary metabolites are organic compounds produced by bacteria, fungi, or plants which are not directly involved in the normal growth, development, or reproduction of the organism. Some common examples of secondary metabolites include ergot alkaloids, antibiotics, naphthalenes, nucleosides, phenazines, quinolines, terpenoids, peptides, and growth...
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Posted by admin on Aug 31, 2021 in |
Herbal medicine is the source of primary health care due to its cultural acceptability and better compatibility with the human body and lesser side effects. Resha-e-Makka (Zea mays) is an important medicinal plant in the Unani system of medicine (USM) due to its multiple therapeutic properties. The review has been reviewed, compiled, and analyzed using references from major databases like classical text and indexed journals. The plant is known to treat different systemic ailments due to the presence of Saponins 3%, Alkaloid, Bitter glycoside, Stearic acids, Tannins, Amine 0.05% etc. In USM, the pharmacological actions of Resha-e-Makka are anti-inflammatory, diuretic, Lithtontroptic, astringent, muhallil Balgham, etc. Zea mays is reported for its antibacterial, anti microbial, anti-deperssant, anti-diabetic, hypolipidemic, antioxidant, hepatoprotective, antimalarial, antipyretic, analgesic, anti-inflammatory, anti-cancer, etc. activity. The review explores the pharmacological, phytochemical, and therapeutic properties of Zea mays Lin. Many pharmacological activities mentioned in Unani medicine are validated and many activities need further exploration due to the immense therapeutic scope in this...
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Posted by admin on Aug 31, 2021 in |
Poor aqueous solubility has been one of the major challenges in modern drug delivery as it hinders the absorption process leading in the decrease of bioavailability. As a consequence of low water solubility of drugs, low oral bioavailability is a growing challenge to the development of new pharmaceutical products. There has been a consistent increase in the number of new pharmacologically active lipophilic compounds that are poorly water-soluble. Approximately 40% of new drug candidates are lipophilic and exhibit poor water solubility. One of the popular approaches of oral bioavailability and solubility enhancement is the utilization of lipid-based drug delivery systems – self microemulsifying drug delivery system (SMEDDS). Self-micro emulsifying drug delivery system (SMEDDS) is one of the exclusive approaches to increase bioavailability by improving solubility for the poorly aqueous soluble drug and to increase the oral absorption of highly lipophilic drugs. These systems have unique property to form oil in water emulsion under gentle agitation provided by digestive motility of the stomach and intestine. A greatest advantages of incorporating...
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Posted by admin on Aug 31, 2021 in |
The noble coronavirus SARS-CoV-2 results in a devastating, multisystem disease among which COVID-19 pneumonia creates serious complications and most of COVID-19 related deaths. COVID-19 patients develop a systemic inflammatory response through interleukin (IL) and tumor necrosis factors. In COVID-19 patients, cytokine storm controlling is the key step for treatment because cytokine attacks own body cells instead of fighting with the virus. We reviewed several literatures to summarize the safety and efficacy of LD-RT in COVID-19 patients. Low dose chest radiation may reduce the inflammation in the lungs in severely ill patients. The radiation offset an immune system called AS a cytokine storm. Several randomized/non-randomized, single/multi-centered, open/close clinical trials are underway in U.S, India, Iran and around the globe. Early studies showed LD-RT reduces the inflammatory cytokines, time of hospitalization, duration of ventilation, and a number of deaths. However, some researchers warned for radiation-induced cancer (lung, breast, and esophageal) and cardiovascular diseases. So, further extensive preclinical studies should be conducted to identify the risk-benefit ratio in COVID-19...
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