Posted by admin on Aug 31, 2021 in |
The non-invasive technique in which a variety of nanoparticles are used to deliver the chemotherapy drug to the location of metastatic cancer has fewer side effects, high bio-availability, and high bio-stability of a drug. The anti-proliferative activity of EGCG is very efficient against a variety of cancer, but the problem is that it can’t withstand the environment of an intestine. One of the nano-system is Spanlastic (type of niosome system) which can carry both lipophilic and hydrophilic drugs. Spanlastic is capable of holding a large amount of drugs; also, the penetration potential of spanlastic is very efficient due to the addition of cholesterol and ethanol in it. Non-ionic surfactant made up of Span-60 (mono-stearate), and the edge activator made of Tween-80 increases the flexibility and deformability of the system. Ethanol injection will be used to prepare the EGCG loaded spanlastic system. After preparing, the Z-average diameter, polydispersity index, and spanlastic will be determined by dynamic light scattering (DLS) and, with the help TEM imaging, will check the shape and...
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Posted by admin on Aug 31, 2021 in |
Covid-19, caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is a life-threatening disease that has been declared a global pandemic. Even with the intervention of numerous medical systems to combat Covid-19, an effective remedy is not yet in sight rather than supportive therapies accompanied with anti-viral drugs and vaccines. The usage of these medicines has caused for unexpected side effects, and at present, various mutant forms of this virus have been identified from different countries. Hence, the necessity of an effective treatment regimen is highly expected. The attention direct towards Traditional Medicine (TM) is increasing day by day as it is well known for immune modulation. Therefore, this review was conducted with the aim of systematically reviewing the relevant literature of TM based on clinical studies conducted on Covid-19 patients and provides a summary on the evidence-based potential use of TM in the treatment of Covid-19. This review was conducted by using the databases; Science direct and PubMed for studies published from 1st of December 2019 to...
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Posted by admin on Jul 31, 2021 in |
Andrographolide is a labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata Nees (Acanthaceae). Andrographolide is isolated by various processes and the simple method is the maceration process. It is bitter in taste and used as hepatoprotective, cholinergic, antispasmodic, stomachic, anthelmentic, alterative, blood purifier, and febrifuge. It promotes the secretion of bile in the liver and is used in jaundice, torpid liver, cold and upper respiratory tract infection. It is also used in the treatment of snake bites and is found to be more effective than the anti-snake venom generally used. Hesperidin is a flavanone glycoside isolated from the peels of Citrus sinensis (Rutaceae). Hesperidin plays an important role in plant defense mechanisms. Hesperidin is commonly isolated by two laboratory processes maceration and continuous percolation method. The major pharmacological actions of the hesperidin reported are anti-hyperlipidemic, cardioprotective, antihypertensive, antidiabetic, antioxidant, anti-inflammatory, and antiartherogenic activity. However, what is noteworthy about this paper is highlighting the evidence-based overview on the chemical and physical nature of Andrographolide and Hesperidin along...
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Posted by admin on Jul 31, 2021 in |
Cancer initiates from the transformation of normal living cells into malignant cells via a multistage event that usually advances from a pre-cancerous phase to a malignant tumour. Anti-metastatic drugs or anti-neoplastic drugs prevent and regulate the growth of onco cells. Based on the mode of drugs, the universally anticancer drugs market is categorized into cytotoxic, targeted, and hormonal drugs. The targeted drugs class is further divided into monoclonal antibodies, tyrosine kinase inhibitors, and others. The worldwide anticancer drugs market falls into five regions: North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa. Cancer is considered the second largest cause of death globally and is responsible for an estimated 9.6 million deaths in 2018. Globally, about 1 out of 6 deaths is due to cancer. Approximately 72% of deaths from cancer occur in developed and developing countries. Synthetic drugs and other modes of treatment are pre-existing. Chemotherapy treatments have its own limitations due to their toxic effects on non-targeted tissues and it further leads to health...
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Posted by admin on Jul 31, 2021 in |
Euphorbia fusiformis Buch.-Ham.ex D. Don, (Synonym: Euphorbia acaulis Roxb) is an infrequent, medicinal, geophytic herb of the family Euphorbiaceae. It is distributed only in few pockets of India, Nepal, Africa and China. In India, it is found to grow in Maharashtra, Karnataka, Gujarat, Goa, Rajasthan, Andhra Pradesh, Madhya Pradesh, Uttar Pradesh, Bihar, Tamil Nadu and West Bengal. Traditionally, local tribal people of India had been using this plant to treat headache, arthritis, gout, paralysis, diarrhoea, abdominal diseases, abdominal tumor, liver disorders, urinary stones, chronic wound cracks, skin disease, eczema and poor lactation. In scorpion and snake bites, plant latex was used as an antidote. Phytochemical analysis of the plant demonstrated the presence of number of primary and secondary metabolites such as flavonoid, phenol, proteins, saponin, phytosterol, triterpenoids, fixed oil and fats. It also contains vitamin C, vitamin E, and minerals. Some of the important phytoconstituents found in roots of Euphorbia fusiformis are Caudicifolin, Ellagic acid, 3, 3′-di-O methylellagic acid and Euphol. Sesquiterpenes, aliphatic compounds and small amount of monoterpenes...
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