Posted by admin on Mar 31, 2021 in |
Biosimilars are the most promising medicines for treating complex diseases. The first biosimilar was approved in India in 2000, and since then, there is no looking back. CDSCO in collaboration with DBT has developed new guidelines in 2012, which were revised in 2016 for pre and post-marketing approval of biosimilars in India. India is one of the leading manufacturers of biosimilars catering to domestic and international market. Soon it will have a vast opportunity to develop more similar biologics as the patent of many biologics is scheduled to expire by the year 2020. India has emerged well in global market of biosimilars. India started its journey with near about US$ 250 million biosimilar market in 2015 and it is estimated to reach around US$ 40 billion in India while US$ 240 billion in world by 2030. Biosimilars are the boon in treating...
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Posted by admin on Mar 31, 2021 in |
Cancer, according to WHO, is a generic terminology for a group of diseases that are characterized by abnormal growth of cells. This uncontrolled, abnormal growth is beyond the natural boundaries of normal cell growth, which can then metastasize to adjoining or distant sites of the body and/or to the organs. Cancer is the second most leading cause of mortality and has resulted in 9.8 million deaths in 2018 alone. Efforts to explore newer anticancer drugs have significantly increased in recent years. Appropriate preclinical experimental screening models can help us apprehend the pathogenesis, complications, and testing of various therapeutic agents. Both in-vitro, as well as in-vivo models are available for the screening of compounds. A preclinical screening model should have a high sensitivity and reproducibility. This review summarizes some conventional as well as newer experimental screening models used for preclinical screening of test compounds for the treatment of...
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Posted by admin on Mar 31, 2021 in |
There has been an exponential growth in plant-based products during the last few decades for the treatment of various ailments. According to literature, about 25% of prescribed drugs are of plant origin globally. One such important plant is Asystasia gangetica, also known as ‘Chinese violet’ or ‘Ganges primrose’ is an ornamental, scattering, groundcover herb. The plant is about 0.30 to 0.60 m in height, mainly distributed in sub-Saharan tropical Africa, Arabia, and tropical Asia (including India). Ethnobotanically, the decoction of its leaves is effective in the treatment of rheumatism, stomachache, anthelmintic, heart pains, asthma, astringent, diaphoretic, woman infertility, etc. It is mainly reported to contain chalcone, biflavons, glucoside, amino acid, iridoid glycoside, etc. Pharmacologically plant is reported to possess anti-asthmatic, anti-hypertensive, anti-diabetic, anti-hyperlipidaemic, anti-microbial, anti-oxidant activity, anti-snake venom, etc. The present review is an attempt to describe the important medicinal properties of A. gangeticain the traditional and modern scientific research. It is concluded that the plant has numerous therapeutic potential which need to be...
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Posted by admin on Mar 31, 2021 in |
Colon targeted drug delivery system is a significant part of the pharmaceutical dosage form. Because the colon targeted formulation system only responds to the colon-specific physiological conditions, a triggering mechanism is required. Site of colon provides local and systemic drug delivery. Inflammatory bowel disease can be treated by localized delivery of drugs. The systemic side effect can be decreased by aiming the medications directly to the colonic cycle. Rectal and oral formulations are the major drug targeting strategies that target the colon by pressure, pH, and micro-flora triggered the release of the drug. Formulation of colon targeted system is a complicated process involving substantial efforts. This article discusses the advantages, limitations, primary and advanced approaches, and evaluation of colon-specific systems and provides information regarding some of the formulations available in the market to treat colon-related disorders. This article also focuses on current and future prospects in the area of colon-targeted...
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Posted by admin on Mar 31, 2021 in |
India is renowned for its rich biodiversity and the Western Ghats, because of its varied topography and ecological conditions support a very rich flora including medicinally valuable aromatic and non-aromatic plant species. The Western Ghats are additionally documented for diversity within the ethnic communities; they have been utilizing the plant wealth for medicinal purposes and have proven successful for generations. Coleus, one of the largest genus of the family Lamiaceae, is well known for its aromatic medicinal plants of ethnomedicinal importance. Among the different species within the genus, Coleus amboinicus and Coleus barbatus are the most documented species with a wide variety of traditional medicinal uses in ayurvedic as well as folklore medicine. Even though the plants such as Coleus malabaricus, Coleus mollis, Coleus urticifolius, Coleus fruticosus, Coleus bishopianus, Coleus paniculatus and Coleus caninus of the Western ghats reported to possess enormous ethnomedicinal uses, very little is known regarding the chemical constituents and biological activities of these species. Numerous new species have additionally been recognized from this area. This...
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