Posted by admin on Jun 30, 2021 in |
Sarcoidosis is a rare autoimmune inflammatory disease, which is difficult to diagnose due to a lack of approved clinical tests. It has been observed in each race, and highest among the Scandinavia, African-American but Asians are less vulnerable to it. It affects most prominently adults from the age group of 20 to 60. The main characterized symptom of this disease is non-caseating granulomas, specifically in the lungs and lymph nodes progressing to lungs impairment to pass oxygen, and finally total failure of lungs as well as heart. The main cause of sarcoidosis is immune irregularities in genetically predisposed individuals which manifests antigen(s) like microorganism or their products, due to an ex-aggregated immune response. There is no specific treatment available, although corticosteroids help in disappearing its symptoms. While more than 50 percent of the patients don’t require any treatment and illness goes on its own, only 10% require treatment in which severe symptoms developed and last long. The current review enlightens the pathogenesis of the disease, clinical indications, diagnostic evaluation,...
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Posted by admin on Jun 30, 2021 in |
Bhavaprakasha is unique in the sense that it shows the slow amalgamation of traditional Indian materiamedica with several new additions which came to the Indian subcontinent through trade and exchanges with foreign civilizations. The Nighantuportion of Bhavaprakasha is an excellent repertoire of herbs and minerals used in Ayurveda. Several plants with properties related to augmentation of ocular function like chakshushya, and to the treatment of eye diseases are mentioned in Bhavaprakashanighantu. Many of these drugs have been subjected to various biomedical in-vitro and in-vivo studies globally over the past decades. They hold the promise of being new therapeutic agents against various ocular diseases like cataracts, diabetic retinopathy, which have no efficient treatment options in existence at the moment. There are more drugs yet to be studied upon. This article is a review of drugs with pharmacological properties related to ocular function or management of eye diseases described in Bhavaprakasha Nighantu and the modern scientific research done on them in recent...
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Posted by admin on Jun 30, 2021 in |
Background and Aim: Coronavirus 2019 (COVID-19) is a pervasive emergency affecting 1-5% of children, among whom the majority are with preexisting comorbidities. This commentary aim is to highlight two such prominent childhood comorbidities, i.e., asthma and type 1 diabetes mellitus (T1-DM), with their pathophysiological link to COVID-19. Method: We searched the Google Scholar and PubMed databases till August 15, 2020, and retrieved the data connected to our aim for reviewing. Results: Asthma and T1-DM in children affect the COVID-19 progression due to their interlinked disease mechanisms with infection. Th-2 (T-helper) low endotype asthma and TI-DM connect by decreased ACE (angiotensin-converting enzyme) receptor expression, whereas Th-2 high endotype intensifies the COVID-19 via declining the IFNs (interferons) related anti-viral effect. Addressing these comorbidities therapeutically in this pandemic includes continuity in respective disease control treatment plans with the use of pressurized metered-dose inhaler (pMDI) with a spacer rather than nebulizers or keeping the low incidence of exacerbations by inhaled/oral corticosteroid and/or Montelukast in children with asthma is recommended. In the case of...
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Posted by admin on Jun 30, 2021 in |
Pectinases are the pectinolytic enzymes that constitute an important component of the plant cell wall and of wide use with their target as pectins. Pectinases cover three different enzymes: Pectin-esterases (PE) act upon ester bonds in pectin breaking them into simpler forms, Polygalacturonases (PG) target the bonds between the galacturonosyl residues, and Pectate lyases (PL) target the alpha 1,4 glycosidic bond. These enzymes can be biosynthesized with the help of various microbes, including bacteria and fungi, using biological waste as a source of nutrients, carbon, and energy. These are commercially important because of their extensive use in the food and textile industry, clarification of beverages, maceration of plant tissue, treatment of wastewater, pulp liquefaction, textile industry and plant fiber processing, coffee, tea and oil extraction, de-gumming plant fibers, and improvement of chromaticity and stability of red wines. This review mainly aims at the pectinase’s, their types, mechanism of action, and the substrates on which they act. It also gives a broad view of the applications of these enzymes in...
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Posted by admin on May 31, 2021 in |
The focus of the current article is to prepare the chrono-modulated dual release formulation using various optimization techniques. The conventional formulations as the Controlled Release Drug Delivery System (CRDDS) are not effective in the chronomodulated formulation. The advancement in research and development in CRDDS leads to the formulation of chronomodulated formulations. Dual release tablets are those in which two drugs are given in a single tablet in different layer as to avoid the incompatibility problem or single drug is given in two different layers as maintenance dose and loading dose. The formulation is fruitful in various diseases such as diabetes, arthritis, asthma, etc., and provides compliance to the patient as a patient has no need to wake up during night hours to take the mediation. The Quality by Design (QbD) techniques is used to make the formulation as much as safe and efficacious. By applying the QbD, product variability is reduced and leads to quality improvement, risk reduction, and production enhancement. In conclusion, chronomodulated drug delivery system using QbD...
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