Posted by admin on Dec 31, 2020 in |
The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body and also to achieve and maintain the desired drug concentration. This could be achieved through multiparticulate dosage form like beads which are divided into many individual units, so, called subunits, each exhibiting some desired characteristics. Micro particulate drug delivery systems have various well-known advantages over single unit dosage form. Preparation of microbeads drug delivery system is one of the alternatives which involve neither use of harsh chemical nor elevated temperature. The conventional techniques involve the use of ionotropic gelation method, emulsion gelation method, polyelectrolyte complexation method, etc. The majority of work has been done on the preparation of microbeads by ionotropic gelation method rather than other methods owing to its ease of preparation. The ionotropic gelation method is based on the ability of polyelectrolytes counter ions to crosslink to form a hydrogel sustained release...
Read More
Posted by admin on Dec 31, 2020 in |
The human gut is colonized by an inherent group of microorganisms that cohabits with us and plays a critical role in maintaining homeostasis. Evidence is being piled up, showing the roles of gut micro-flora in the severity and consequences of COVID-19. The gut-lung cross talk is thought to mediate this outcome resulting in an alteration of gut-microbiome, a phenomenon known as gut-dysbiosis during the progression of SARS-CoV-2 infection. A destabilization of gut-microbial homeostasis can upset the host immune system causing critical outcomes in COVID-19 patients with preexisting co-morbidities like CVD and diabetes. This review underlies the interaction between gut micro-flora and SARS-CoV-2 infection and the consequent clinical risk factors. While we are still in the hunt for effective medication and vaccine, the administration of prebiotics along with probiotics as a prophylactic treatment for the management of patients with COVID-19 could help reduce the pro-inflammatory state leading to the new insights of novel...
Read More
Posted by admin on Dec 31, 2020 in |
Lipid–polymer hybrid nanoparticles (LPNs) are next-generation core-shell nanoparticle structures comprising polymer cores and lipid/lipid–PEG shells, which produce complementary characteristics of both polymeric nanoparticles and liposomes, specifically in terms of their physical stability and biocompatibility. Recently the LPNs have been shown to have superior in vivo cellular delivery efficacy compared to that obtained from polymeric nanoparticles and liposomes. Since their inception, the LPNs have advanced significantly in terms of their preparation strategy and scope of applications. LPN preparation has undergone a significant shift from the traditional two-step method to the now widely used two-step method, which is more complex principal-wise and yet easy to perform, relying on self-assembly of lipid and polymer. This has resulted in a better product and high production throughput as well. Unlike the initial days when LPNs were used mainly for single drug delivery in anticancer therapy, now they are widely used in combinatorial and active drug targeted delivery, delivery of genetic material, vaccines, and in advanced diagnostic procedures as well. This review throws light on...
Read More
Posted by admin on Dec 31, 2020 in |
Biopharmaceuticals or biologics are the therapeutic agents which are biomolecules (DNA, Protein, Peptide, RNA, antibodies) in nature. These are high molecular weight (300-1000000Da) molecules, which deify Lipinski rules. At present, a large portion of the market share is occupied by protein biotherapeutics. However, peptide-based therapeutics is replacing protein biotherapeutics, as the former has a broad spectrum of action, high activity at low concentration, efficiency, safety, target selectivity, etc. Currently, there are more than 130 proteins and 140 peptide-based therapeutics in the market, and around 500 peptides are in preclinical development. To release the drug at the target site with maximum efficacy and minimum side effects, the selection of a drug delivery route is very important. Some of the drug delivery routes are Oral drug delivery system (DDS), Parenteral DDS, Topical DDS, Pulmonary DDS, Nasal DDS, Brain targeted DDS, Stem cell DDS, Peptide DDS, Self-assembled peptide DDS, Rectal DDS, etc. In comparison to small molecules drug delivery system, there are very few delivery options for the biotherapeutics due to the...
Read More
Posted by admin on Dec 31, 2020 in |
The coronavirus pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is unique and unprecedented in many respects and has challenged healthcare systems worldwide. Currently, there is no specific treatment or cure in the Western medicine system. Research is underway to develop effective vaccines and medications for the disease. In this scenario, the scientific community must think about Complementary and Alternative medicinal systems available worldwide. This review will present an overview of the coronavirus, including its history of origin, spread, and epidemiology, along with a comparative view of SARS-CoV, SARS-CoV-2, and MERS. An attempt was also made to highlight the role of traditional systems of medicine in preventing the coronavirus pandemic by providing an overview of the concept of the epidemic, its pathogenesis, and prevention strategies in two of the most popular systems of traditional medicine, namely, Traditional Chinese Medicine (TCM) and...
Read More
