Posted by admin on Jul 31, 2025 in |
The aim of the study is to evaluate the prevalence and impact of advancements in the diagnosis and treatment of Adenosine Deaminase Severe Combined Immunodeficiency (ADA-SCID) and propose novel strategies for improved management and therapeutic outcomes. A comprehensive review was conducted according to PRISMA guidelines, focusing on advancements in ADA-SCID. Gene variant data were analysed using databases like dbSNP and ClinVar, with pathogenicity assessed using tools such as SIFT and PolyPhen. The methodology includes a comprehensive review of studies from 1970–2024 was performed, emphasizing diagnostics (e.g., TREC screening, genomic sequencing) and therapies (e.g., enzyme replacement therapy, HSCT, and gene therapy). The study highlighted the pathogenic variants of the ADA gene contributing to ADA-SCID, diagnostic challenges, and the associated vaccination risks. Current therapeutic approaches, including enzyme replacement therapy, hematopoietic stem cell transplantation, and gene therapy, were reviewed, emphasizing their benefits and limitations. Novel therapies, such as CRISPR-Cas9 base editing, in-utero stem cell transplantation, and iPSC-derived treatments, demonstrated promising potential for future management of ADA-SCID. The review consolidates insights into ADA-SCID...
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Posted by admin on Jul 31, 2025 in |
Andrographolides are bioactive compounds derived from the plant Andrographis paniculata that have gained attention for their potential as an immune modulator. Research indicates that andrographolides exhibit anti-inflammatory, antioxidant, and immunomodulatory properties. It can enhance the activity of immune cells, such as macrophages and T lymphocytes, and modulate cytokine production, which helps balance immune responses. Clinical studies suggest that andrographolides may be beneficial in treating respiratory infections, reducing inflammation, and potentially providing protective effects against autoimmune conditions. Andrographolides have been shown to inhibit key inflammatory pathways, including the NF-κB, MAPK, and STAT3 signalling pathways, which play crucial roles in the immune response. Andrographolides have been studied in combination with conventional chemotherapy drugs, showing a synergistic effect that enhances the efficacy of chemotherapy while reducing side effects. While results are promising, more extensive clinical trials are necessary to establish its effectiveness and safety for long-term use. Andrographolides show potential as a natural immune-supportive agent, warranting further exploration in integrative health...
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Posted by admin on Jul 31, 2025 in |
Pharmaceutical technology has been using artificial intelligence more and more in recent years. This technology can help save time, money and also very helpful while improving understanding of the links between various formulation and process parameters. To tackle both specific and complex issues, artificial intelligence (AI) leverages human knowledge and gains knowledge from the solutions it generates. Drug development could undergo a revolution thanks to remarkable increases in processing capacity and advances in artificial intelligence. Reduced efficiency and rising R&D expenditures are currently making it difficult for the pharmaceutical industry to continue its medication development programs. Artificial intelligence (AI) has been used more and more in many facets of society, but especially in the pharmaceutical business. The use of AI in several areas of the pharmaceutical business, such as clinical trials, medication repurposing, drug discovery and development, and increasing pharmaceutical production, is highlighted in this article. Moreover, AI boost clinical trials process by identifying suitable candidates and predicting treatment outcomes and maximised efficiency and accuracy. In personalized medicine, AI...
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Posted by admin on Jul 31, 2025 in |
Introduction: The use of traditional herbal medicines in conjunction with modern pharmaceuticals is a growing trend. However, the concurrent use of these therapies can lead to significant pharmacological interactions affecting drug metabolism, efficacy and safety. Objective: This systematic review aims to provide a comprehensive overview of pharmacological interactions between traditional herbal medicines and modern pharmaceuticals, highlighting common interactions, elucidating underlying mechanisms and offering clinical recommendations. Methods: A systematic search was conducted in databases including PubMed, MEDLINE and the Cochrane Library for studies published up to July 2024. The review included clinical trials, observational studies, and reviews that examined interactions between herbal medicines and pharmaceuticals. Data were extracted and assessed for quality using the Cochrane risk-of-bias tool and the Newcastle-Ottawa Scale. Results: Out of 3,245 records identified, 50 studies were included in the qualitative synthesis and 20 studies were included in the quantitative synthesis. Common herb-drug interactions were identified, such as St. John’s Wort with antidepressants and anticoagulants, Ginkgo Biloba with anticoagulants and anticonvulsants, and Ginseng with antidiabetic drugs and...
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Posted by admin on Jul 31, 2025 in |
Micronutrient deficiencies are an important driver of morbidity and mortality associated with non-communicable diseases. According to the World Health Organization, more than two billion individuals are micronutrient deficient worldwide, with India home to over half of them. India needs to actively fight against the severe effects of malnutrition since, despite the nation’s strong economic growth and declining poverty rate a sizeable section of the population still has sub-optimal nutrition. This review primarily focuses on the current situation of micronutrient status in the nation, including driving factors that contribute to micronutrient deficiency, clinical perspective and challenges, role of supplementation, long-term and sustainable strategies to reduce micronutrient deficiency, as well as challenges in adapting the micronutrient supplementation practices as in the developed world by the Indian community. To achieve India’s optimum nutritional status, it is required to identify strategic initiatives to overcome practical challenges and implement the right balance of biofortification, nutritional diversification, and sufficient...
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