Posted by admin on Dec 31, 2020 in |
Lipid–polymer hybrid nanoparticles (LPNs) are next-generation core-shell nanoparticle structures comprising polymer cores and lipid/lipid–PEG shells, which produce complementary characteristics of both polymeric nanoparticles and liposomes, specifically in terms of their physical stability and biocompatibility. Recently the LPNs have been shown to have superior in vivo cellular delivery efficacy compared to that obtained from polymeric nanoparticles and liposomes. Since their inception, the LPNs have advanced significantly in terms of their preparation strategy and scope of applications. LPN preparation has undergone a significant shift from the traditional two-step method to the now widely used two-step method, which is more complex principal-wise and yet easy to perform, relying on self-assembly of lipid and polymer. This has resulted in a better product and high production throughput as well. Unlike the initial days when LPNs were used mainly for single drug delivery in anticancer therapy, now they are widely used in combinatorial and active drug targeted delivery, delivery of genetic material, vaccines, and in advanced diagnostic procedures as well. This review throws light on...
Read More
Posted by admin on Dec 31, 2020 in |
Biopharmaceuticals or biologics are the therapeutic agents which are biomolecules (DNA, Protein, Peptide, RNA, antibodies) in nature. These are high molecular weight (300-1000000Da) molecules, which deify Lipinski rules. At present, a large portion of the market share is occupied by protein biotherapeutics. However, peptide-based therapeutics is replacing protein biotherapeutics, as the former has a broad spectrum of action, high activity at low concentration, efficiency, safety, target selectivity, etc. Currently, there are more than 130 proteins and 140 peptide-based therapeutics in the market, and around 500 peptides are in preclinical development. To release the drug at the target site with maximum efficacy and minimum side effects, the selection of a drug delivery route is very important. Some of the drug delivery routes are Oral drug delivery system (DDS), Parenteral DDS, Topical DDS, Pulmonary DDS, Nasal DDS, Brain targeted DDS, Stem cell DDS, Peptide DDS, Self-assembled peptide DDS, Rectal DDS, etc. In comparison to small molecules drug delivery system, there are very few delivery options for the biotherapeutics due to the...
Read More
Posted by admin on Dec 31, 2020 in |
The coronavirus pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is unique and unprecedented in many respects and has challenged healthcare systems worldwide. Currently, there is no specific treatment or cure in the Western medicine system. Research is underway to develop effective vaccines and medications for the disease. In this scenario, the scientific community must think about Complementary and Alternative medicinal systems available worldwide. This review will present an overview of the coronavirus, including its history of origin, spread, and epidemiology, along with a comparative view of SARS-CoV, SARS-CoV-2, and MERS. An attempt was also made to highlight the role of traditional systems of medicine in preventing the coronavirus pandemic by providing an overview of the concept of the epidemic, its pathogenesis, and prevention strategies in two of the most popular systems of traditional medicine, namely, Traditional Chinese Medicine (TCM) and...
Read More
Posted by admin on Nov 30, 2020 in |
Background: In honor of a dutch botanist, Abraham Munting, the tree was named Muntigia calabura L. The Jamaica cherry, M. calabura is a shrub or tree which is native to Jamaica, Brazil, Mexico, and North America. M. calabura is a well-known, fast-growing tree clasped with different medicinal and health benefits. Different parts of the tree are being used for various ailments in different parts of the world. Objective: To summarize updated information regarding the pharmacological activities of Muntingia calabura L. Materials and Method: Few databases like Google Scholar, Science Direct, and Pub Med were used for the literature survey. Google and Bing search also carried out using the common and scientific names of the plant as keywords. For reviewing, articles that are related to ecology and agriculture are excluded. And articles that were not in the English language were also excluded. Results: Above mentioned search engines yielded 47 articles. Among them, 17 articles which were published between 2015 and 2019 were selected for inclusion in this review. From the...
Read More
Posted by admin on Nov 30, 2020 in |
Nowadays, a very large proportion of new drug candidates arising from drug discovery programs are water-insoluble and, for that reason, poorly bioavailable. The trouble is even more complex for drugs that belong to the BCS Class II category. To overcome these problems, nanotechnology is used to enhance the solubility as well as bioavailability of poorly soluble drugs. In the ocular drug transport system, ocular infections are dealt with by various topical drug applications in the form of solutions, suspensions, and ointment. These conventional dosage forms go through from the problems of poor ocular bioavailability due to minimal ocular residence time because of various anatomical and pathophysiological barriers prevailing in the eye. Nanotechnology refers to the particle size range of 1–1000 nm. Nanosuspensions are a part of Nanotechnology. Nanosuspensions are defined as the submicron colloidal dispersions of pharmaceutically active ingredient particles in a liquid phase, the measurement under 1μm, without any matrix material, which is stabilized by surfactants and polymers. Major concerns with topical ocular delivery include poor drug absorption...
Read More
