Posted by admin on Jun 30, 2020 in |
Helicobacter pylori (HP) as a non-invasive microbe, has been cloned in the stomach. The most important side effects of HP are inflammation, peptic ulcer (PU) and gastric cancer (GC). Control of inflammation, leads to preventing other HP side effects and antibiotic resistance, therefore it is important to use of natural anti-inflammatory compounds. In present study, review the effect of Zingiber officinale (Z. officinale) in controlling side effects of HP in human. Related articles were collected in Google Scholar, Pub Med, Science direct, Scientific Information Database and Scopus. For this purpose, using the terms pylori, Zingiber officinale and Ginger in the title of the all articles published to 2020. Based on search results, were absorbed 15 articles in Google Scholar, 10 articles in Pub Med, 1 articles in Science direct, 1 article in Scientific Information Database and 13 articles in Scopus. After removing the same articles, protocols and no English language articles, finally reviewed, 8 English-language articles and 1 Farsi language article. Regard to long-term treatment of HP and the...
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Posted by admin on Jun 30, 2020 in |
This review enumerates the classification, role, and importance of carbohydrate derivatives and glycomimetics. Carbohy-drates are polyhydroxy aldehydes or ketones. Carbohydrates are the most abundant dietary source of energy for all organisms. They are precursors for many organic compounds such as fatty acids and amino acids. They can participate in the structure of cell membranes and cellular functions such as cell growth, adhesion, and fertilization. Glycomimetics are the compounds of low molecular weight based on the structure of functional carbohydrates. The rational style of tiny molecule glycomimetics that exhibit improved drug-like properties like enlarged affinity, blood serum half-life, stability, and bioavailability. Currently, two successful drugs for influenza (Tamiflu, Relenza) are mimicking (Glycomimetics) the transition state of the enzymatic cleavage of the terminal N-acetyl neuraminic acid. A hopeful example is the antibody 2G12, which has been shown to neutralize HIV infectivity. The functional carbohydrates identified in these recognition processes themselves do not make good drug candidates. Rather, their bioactive conformations in their receptor sites can be empirically determined by physicochemical methods...
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Posted by admin on Jun 30, 2020 in |
Nanotechnology is going to revolutionize the world. According to the National Nanotechnology Initiative (NNI), nanotechnology refers to the study of all particles in the range of 100 nanometers or less. One of the most important advantages of the smaller particle size is the ratio of surface atoms or molecules to the total number increases. That means they have large surface areas that lead to increase in surface activity and produce changes in their physical properties and biological properties. In the pharma-world, the applications of nanotechnology mean drugs containing nano-sized active ingredients. They are well used to cure HIV, Cancer and other harmful diseases; they can restore lost tissue at the cellular level, useful for monitoring, diagnosing and fighting sickness. The smaller drug delivery systems permit the deposition of medications in previously inaccessible areas of the body; it also has great importance in the treatment and diagnosis of certain diseases like cancer. A recent discovery in the field of drug delivery is target therapy, which improves the diagnostic tests and...
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Posted by admin on Jun 30, 2020 in |
The contemporary development in the drug delivery system is a seamless process. Any delivery system targeting a molecule to a particular site is always been appreciated. This requirement can be fulfilled through a specialized drug delivery system that can easily target the drug at the site of action without compromising its efficacy and quality. Few new drugs typically cannot be effectually delivered by conventional dosage form. Hence, benefits from targeted, localized delivery of therapeutic agents are other driving forces for the current scenario. Nanosponge technology has been introduced to assist the release of drug in a controlled manner over time to reduce systemic toxicity and severe reactions. Nanosponges are tiny sponges with a size of about a virus (250 nm-1 μm), which consist of cavities that can be filled with a wide variety of hydrophilic as well as hydrophobic drugs, which can be further incorporated into a pharmaceutical dosage form such as oral, parenteral, topical or inhalation. The sighting of nanosponge has become a noteworthy step in overcoming certain...
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Posted by admin on Jun 30, 2020 in |
Plants have great potential for the treatment and management of many diseases and have been used in many countries for the treatment of different diseased conditions. The medicinal value of plants lies in their bioactive phytochemical constituents that produce definite physiological actions in living beings. Many medicinal plants contain some chemical constituents that may cause harmful effects to humans if consumed in large quantities. Alkaloids occurring in large amounts could make plants poisonous despite its medicinal effects. Datura metel L., a member of the family Solanaceae, is known as Jimson weed and in Arabic known as “Jaozmasel”, is one of the well-known folk medicinal herbs with wide application, Chemical investigation of which revealed its components as alkaloids, carbohydrates, and proteins among which alkaloids including scopolamine, hyoscyamine and atropine are the main active ingredients that exhibits various activities, such as anti-asthmatic, sedative, analgesic and anti-rheumatoidal effects. Besides of medicinal usage, D. metel is one of the most abused plants all over the world because of its unrestricted availability, especially in...
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