Posted by admin on Oct 31, 2020 in |
The imbalance between aggressive (pepsin, Hydrochloric acid) and protective elements (bicarbonate and mucosa) in the inner lining of the stomach lead to the formation of peptic ulcers. The presence of Body fluids, mucosal hydrophobicity, fast epithelial cell recharging, and rich mucosal blood flow is involved in mucosal protection of the Stomach. Prostaglandins E2 and I2 are the predominant prostaglandins which synthesized by the gastric mucosa and known to hinder the emission of gastric acid and stimulate the discharge of body fluid and bicarbonate. The treatment of peptic ulcers can either be achieved with declination in aggressive elements or elevation of mucosal resistance in the stomach and duodenum with cytoprotective agents. In this review, 30 herbal medicinal plants have been discussed along with its respective extracts; these are Bauhinea veriegata, Euphorbia umbellata, Azadirachta indica, Centella asiatica, Indigo feratinctoria, Mangofera indica, Moringa oleifera, Mimosa pudica, Aegle marmelos, Lawsonia inermis, Tephrosia purpuria, Plantago lanceolata, Solanum nigrum, Annonas quamosa, Ocimum sanctum, Morus alba, Pinusrox burghi, Allium sativum, Hibiscus cannabinus, Emblica officinalis, Curcuma longa,...
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Posted by admin on Oct 31, 2020 in |
Carbuncle is a serious skin disease that affects tribal communities very quickly. The disease is generally caused by Staphylococcus aureus, Escherichia coli, or Streptococcus pyogens. Due to increasing drug resistance in these bacterial strains, it has become very difficult to treat carbuncle with modern antibiotics. The information about tribal peoples using invasive weeds to treat carbuncle is empirical due to the lack of scientific validation. In this review, we focused on the antibacterial potential of invasive weeds used for the treatment of carbuncle in Purulia district of West Bengal, India. Studies by many researchers showed that those invasive weeds strongly inhibited Staphylococcus aureus, Escherichia coli, and many other pathogenic bacterial strains. So, this review work scientifically validates the use of invasive weeds for the treatment of carbuncle by tribal peoples of Purulia. This review work will also help in the discovery of new antimicrobial agents from invasive weeds and introducing them to the modern day’s...
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Posted by admin on Oct 31, 2020 in |
Hydroxychloroquine (HCQ) belongs to the class of 4-aminoquinolines. It is a hydroxylated version of chloroquine with a similar mechanism of action but rather a safe profile. It is primarily an antimalarial drug but has been extensively used for treating rheumatoid arthritis, porphyria, discoid and systemic lupus erythematosus as well. Most recently, this drug has found a place in the treatment of COVID-19 with successful results. It is relatively a safer drug to treat COVID-19 in pregnant ladies, diabetic and hypertensive patients. This molecule has found its successful and safer use as a pediatric drug. The World Health Organization (WHO) has listed hydroxychloroquine as an investigational drug for efficacy against SARS-COV-II. COVID-19 is spreading at a tremendous rate, and we need a less expensive drug against the virus, especially in countries with high poverty. The production cost of this drug is very low, and so is its retail cost. These collective advantages of hydroxychloroquine make it a suitable, effective, safer, and readily available drug candidate for COVID-19...
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Posted by admin on Oct 31, 2020 in |
Gastro-retentive drug delivery system is the novel controlled release system that overcomes the problem like the first-pass metabolism, narrow index of absorption, unstable in intestinal pH, low bioavailability. Different approaches to GRDDS are floating, mucoadhesive, swelling, high density, magnetic drug delivery system. The floating drug delivery system is the most promising approach. The dosage forms remain buoyant for a longer duration of time in the gastric fluid due to the low density of dosage form. Gastric residence time is increased. In this system, there is site-specific drug delivery in the upper part of GIT. Drug release is a slow and controlled manner; drug absorption is increased. The bioavailability of drug is enhanced. Floating microspheres are gaining attention because it remains buoyant for longer time and uniform distribution of drug over the gastric fluid. Fluctuation in plasma drug concentration is reduced. Gastro-retentive dosage form prolong dosing interval reduce the frequency of drug administration so increase in patient compliance. GRDDS is useful for sustained/controlled drug delivery. This article gives an overview...
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Posted by admin on Sep 30, 2020 in |
The liver is the most vital organ in our body, involved in several vital functions such as metabolism, secretion, storage as well as detoxification of several drugs and xenobiotic. Liver cell injury caused by various toxic chemicals like certain antibiotics, chemotherapeutic agents, carbon tetrachloride, thioacetamide, excessive alcohol consumption microbes and so, on. Due to liver disease worldwide, approximately 2 million deaths, 1million due to complications of cirrhosis, and 1 million due to viral hepatitis and hepatocellular carcinoma have been found every year. Now a day number of synthetic medicine available in the market for the treatment of liver disorders, but they have lots of side effects. So, the developed countries recently give their interest in herbal drugs. Many Ayurveda herbs, such as Andrographis, Punarnava, kokum, and soon have a long history of traditional uses in revitalizing the liver and treating liver dysfunction from the various literature survey this can be concluded that the plant containing a high amount of terpenoids possess good hepatoprotective effect. There are some plants enriched...
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