Posted by admin on Jul 31, 2025 in |
A topical drug delivery system involves applying medication to the skin for therapeutic effects or to treat skin disorders. Traditional gels often struggle to deliver hydrophobic drugs effectively, a challenge that can be overcome with emulgels. Emulgels, which combine emulsions and gels, create a dual-release control system that enhances medication efficacy. This innovation is essential in topical delivery systems, significantly improving bioavailability and patient compliance. Emulgel are widely utilized in numerous cosmetic products and for medical applications such as analgesic, antifungals, anti- inflammatory and anti-acne therapies. These topical administration systems have the major benefit of being able to avoid first-pass metabolism, which increases the active compounds’ bioavailability. Emulgels are non-greasy, thixotropic, and easily spreadable, having beneficial qualities for dermatological uses. They also have a longer shelf life because they are water-soluble, emollient and simple to remove. Emulgels are a noteworthy advancement in the field of topical drug administration because of their translucent and visually pleasant look, which also improve user experience. It is a very productive area of research...
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Posted by admin on Jul 31, 2025 in |
Aquasomes are a highly advanced nanoparticulate transport system in nanotechnology. It is mostly utilized for medication delivery. These carriers are differentiated by their three-layered structure, which includes a solid nanocrystalline core (often calcium phosphate or ceramic diamond), a polyhydroxyoligomeric film, and functional properties. The core is solid mechanical strength and stability, but the carbohydrate covering protects the bioactive compounds from dehydration and denaturation. Aquasomes are typically ranging from 60 to 300nm, making them appropriate for a variety of biomedical applications. One of the key benefits of aquasomes in their capacity to deliver medicines, proteins, peptides and genes to particular locations in the body with high precision. This tailored delivery technology increases medicinal efficacy while minimizing negative effects. Additionally, aquasomes provides delayed and prolonged release of the encapsulated compounds, which improves overall treatment outcomes. Aquasomes have demonstrated great potential for delivering insulin, vaccinations and other medicinal substances. Their biocompatibility and capacity to maintain the stability of sensitive molecules make them an adaptable tool in creation of improved drug delivery...
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Posted by admin on Jul 31, 2025 in |
Background: Capsaicin, a bioactive compound derived from the dried fruit of the Solanaceae family, is widely recognized for its therapeutic potential. Its mechanism of action involves interaction with TRPV1 receptors, leading to analgesic effects and modulation of neurogenic inflammation. Objective: This review explores the therapeutic applications of capsaicin, particularly its role in treating non-allergic rhinitis, neuropathic pain, and inflammatory conditions. It also highlights its potential in preventing pneumonia and cluster headaches. Methods: A comprehensive review of existing clinical studies and randomized controlled trials (RCTs) observational studies, and systematic reviews, Randomised placebo- controlled, double blind study, Clinical case series with pre-post outcome assessment was conducted to evaluate capsaicin’s efficacy, and mechanisms of action. Special emphasis was placed on intranasal formulations and their impact on nasal sensory nerve Fibers. Results: Capsaicin has demonstrated significant benefits in reducing nasal symptoms, improving nasal airflow, and alleviating neuropathic pain. Repeated nasal applications have been shown to provide prolonged relief for idiopathic rhinitis, while intranasal capsaicin has been effective in cluster headache prevention. Studies indicate...
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Posted by admin on Jun 30, 2025 in |
Circadian clock is an impressive timing system responsible for the control of several metabolic, physiological and behavioral processes. Chronotherapeutic is an approach that aligns the timing of drug delivery with the rhythms of diseases or disorders to optimize therapeutic responses and minimize side effects. This method ensures the purposeful and controlled release of medications in varying amounts over a 24-hour period. Chronotherapeutic drug delivery systems are becoming increasingly important in pharmaceutical technology, as they reduce dosing frequency and toxicity while delivering drugs in sync with the circadian rhythm (CR) of specific diseases, ensuring optimal treatment when symptoms are at their peak. Eventually, the benefit goes to the patient due the compliance and convenience of the dosage form. Chronotherapy is the conveying drugs in the body at the target site by maintaining perfect synchronicity with circadian rhythms. Chronotherapy refers to the use of circadian, ultradian, in radian& seasonal or other rhythmic cycles in the application of therapy. Some of the conditions, which may be significantly benefited, are hypertension, myocardial infarction,...
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Posted by admin on Jun 30, 2025 in |
Hydrogels are three-dimensional polymeric network structures having high water content. Stimuli-responsive or smart polymers are macromolecules that show a significant physiochemical change in response to small changes in their environment. These smart hydrogels with chemical and structurally responsive moieties show excellent characteristics of reacting under different environmental conditions such as temperature, pH, light, magnetic field, ionic factors, etc. These polymers have the ability to observe a change (stimulus) in their environment, respond to it immediately, and then return to their original shape/state when the stimulus is removed. Due to the high-water content of hydrogels and more similarity with biological tissues, hydrogels provide an ideal environment for cell survival, and structure which mimics the biological tissues. More water content, soft consistency and low interfacial tension with biological fluids makes them biocompatible. Due to their superior biocompatibility and low toxicity hydrogels have a significant role in the biomedical fields. In biomedical field, these super intelligent hydrogels have gained a significant interest in tissue engineering, drug delivery, diagnostics, imaging and optics. The...
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