Posted by admin on Mar 31, 2025 in |
Nanocrystals are crystalline particles having particle size range of 100 to 1000 nm. However, these nano-sized systems are thermodynamically unstable, stabilizers are required to incorporate them. The poorly soluble drugs lead to problems like poor absorption and therapeutic failure. One such method to overcome these solubility problems is the development of nanocrystals. These systems reduce particle size that increases surface area and hence dissolution. Nanoscience technology results in improving solubility, bioavailability and dissolution rate of poorly water-soluble drugs. According to the Noyes-Whitney equation, there is a direct relationship between dissolution rate and surface area of drug particles. Various methods of preparation nanocrystals are Crystallization method, Anti-solvent crystallization, High gravity-controlled precipitation. Evaluation of nanocrystals with different...
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Posted by admin on Mar 31, 2025 in |
Drugs taken by humans and animals find their way into rivers, lakes, and even drinking water and can have devastating effects on the environment. This review summarizes the research regarding pharmaceutical industry emissions and the health risks of pharmaceutical wastewater exposure.The present review is prepared by the extensive literature survey using different search engines like google.com, PubMed, SCOPUS, Medline, Ind Med, and the library of Galgotias University, Greater Noida. This review observed the consumption of medicinal products as one of the main sources of environmental contamination due to excretion (urine, feces) and improper disposal of unused or expired medicines (toilet, sink, litter). Some medicinal products, in particular anti-parasiticides, antimycotics, antibiotics, and estrogens, which can all have ecotoxicological effects, pose environmental risks in specific cases. The supervision of pharmaceutical waste poses a great challenge to policy planners, city administrators, medical personnel, and workers in the recycling industry. It is interdisciplinary, involving pharmacy, nursing, environment services, infection control, quality assurance, risk management, etc. According to the most recent data on water quality in...
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Posted by admin on Mar 31, 2025 in |
The combination of bioinformatics and AI improves the precision and productivity of medication development. Artificial intelligence (AI)-powered tools such as AlphaFold and Atomwise speed up the discovery process, and natural language processing (NLP) helps with literature mining and medication repurposing. Advanced approaches such as automated drug testing and quantum computing are also being studied. Despite challenges such as legal constraints and data quality difficulties, the report emphasizes the potential for these technologies to alter precision medicine in the future. This review looks at how bioinformatics and artificial intelligence are altering the pharmaceutical sector. Especially for complex diseases such as neurodegenerative disorders, conventional drug development approaches are costly, time-consuming, and yield low-quality results. AI methods such as machine learning (ML) and deep learning (DL) significantly speed up drug discovery by predicting drug-target interactions, optimizing drug design, and analyzing ADMET profiles. Meanwhile, bioinformatics facilitates the understanding of biological data by means of the analysis of proteomic, metabolomic, and genomic data. This allows greater...
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Posted by admin on Mar 31, 2025 in |
Recently care regarding functional finishing of medical apparels such as liquid/blood repellent and antimicrobial has increased due to the risk of harmful microbes generation on these fabrics while coming in contact with fluids such as blood, sebum etc. Of the various medical textiles, surgical apparels are important textile products as they protect health care workers from microbial contamination. As consumers have become more aware of hygiene and potentially harmful effects of microbes, the demand for antimicrobial finished clothing is increasing. Different chemicals and heavy metal finished fabrics even though provide good liquid/blood repellent and antimicrobial activity, but these compounds cannot be used for the development of surgical gown due to factors like toxicity and non-biodegradability. Over the last few years, several attempts have been made to replace petroleum products with renewable and biodegradable components. Hence, fabric finished with chitosan (natural polymer)-herbal bionanocomposite are considered significant for fulfilling these objectives. This review discusses different protective textiles prepared with different antimicrobial and liquid/blood repellent finish used in medical textiles. It also...
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Posted by admin on Mar 31, 2025 in |
Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity globally, with 17.9 million deaths in 2019. In India, the CVD epidemic is characterized by rapid accumulation, early age of disease onset, and high case fatality rates. India experienced a 59% increase in premature mortality from 23.02 million in 1990 to 37. Million in 2010. Despite improvements in diagnosis and treatment, heart disease remains prevalent, with a 50% chance of developing it by age 45. The main causes of CVD are ischemic heart disease and stroke. India’s age-standardized CVD death rate is higher than the global average. Artificial intelligence can enhance the identification and treatment of cardiovascular disease by improving quality control and enhancing medical professionals’ expertise. This technology can be used in standard clinical procedures, including nanotechnology-based interventions, risk factors determination, treatment regimens, and patient tracking for chronic cardiovascular diseases. This article highlights the global and Indian burden of cardiovascular diseases (CVD), with rising mortality and early disease onset. It emphasizes the need for improved diagnosis and...
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