Posted by admin on Apr 30, 2020 in |
Taxol is an important drug used for the treatment of various types of cancer. It is primarily obtained from Taxus brevifolia bark and has a long history of the developmental program of 50 years. It functions as a microtubule-stabilizing compound and inhibits mitosis of cancer cells, thereby providing a protective role in the treatment of cancers. In addition to it, taxol also interferes with a number of biochemical pathways and protein to bring about apoptosis and cell death. Since its inception, taxol has undergone various levels of modifications and formulations with a motive of making its action more effective. This has led to the development of Paclitaxel by Bristol-Myers Squibb for large scale commercialization. Consequently other semi-synthetic variants such as Docetaxel and Cabazitaxel were also developed for better actions. All these compounds are collectively called as Taxanes and contain a common ringed baccatin III structure in its molecule. This review is an attempt to illustrate the gradual development of anticancer taxanes from its precursor Taxol and its various pharmacological...
Read More
Posted by admin on Apr 30, 2020 in |
Type 2 diabetes mellitus (T2DM) is a chronic disease, and most patients ultimately require two or more anti-hyperglycemic drugs along with lifestyle changes to achieve and maintain glycaemic control. Sodium-glucose co-transporter 2(SGLT2) inhibitors, such as Dapagliflozin, are the newest class of antidiabetic drugs approved for the treatment of T2DM. Dapagliflozin is a highly selective SGLT2 inhibitor that decreases glucose reabsorption by kidneys and thus lowers blood glucose by increasing glucose excretion in urine output. Dapagliflozin effectively improves glycaemic control by increasing the renal excretion of excess glucose. In clinical trials, dapagliflozin has been well-tolerated and safe to be administered to the major population. It has additional benefits of weight loss, low risk of hypoglycemia, reduction in blood pressure, and cardiovascular benefits. Dapagliflozin can be administered as monotherapy on in combination with other antidiabetic drugs. Thus, Dapagliflozin offers a novel treatment option for type 2 diabetes mellitus with additional...
Read More
Posted by admin on Apr 30, 2020 in |
Plants form the basis of human and animal life. Plants are better choice for medicinal applications when compared to synthetic chemicals and the nature has provided various types of medicinal plants. Jasminum grandiflorum Linn. (family Oleaceae) is a night bloomy flowering plant and is an important source of methyl jasmonates which find utility in plant defense, fruit ripening, plant growth senescence and other physical processes. The aroma plant Jasminum grandiflorum Linn. is native to tropical and warm temperate regions and the plant is observed to have favorable properties which can be used to treat numerous ailments. The leaves of the plant find clinical use in Ayurveda for wound management. The flowers of the plant are used to adorn the women coiffure. In this article, an attempt has been made to provide an updated review on this plant with focus on the isolation and quantification of chemical constituents, medicinal potential and patents on the medicinal and cosmetic formulations comprising Jasminum grandiflorum...
Read More
Posted by admin on Apr 30, 2020 in |
COVID-19 is a disease caused by the novel coronavirus, which was initially called 2019-nCoV, consequently termed as SARS-CoV-2 by the experts of the International Committee on Taxonomy of Viruses (ICTV) as it is exceptionally alike to the virus that caused the SARS outbreak in 2002 to 2003. World Health Organization already had declared COVID-19 as an international emergency as the disease is spreading at alarming levels. COVID-19 has affected more than 1,016,372 people around the world and killed more than 53,238 people. And even where the virus hasn’t yet spread, hospitals and clinics around the world have been preparing for a rush forward of coronavirus patients as a priority over everyday illnesses they treat. The label ‘international emergency’ has triggered governments of various countries to activate vigilance plans and probably take emergency measures to protect the public, such as more strong travel and trade restrictions. It is being observed that this is the first time this kind of virus, a coronavirus, has been labeled a pandemic, “but at the...
Read More
Posted by admin on Apr 30, 2020 in |
The mammalian central nervous system is composed of the brain and spinal cord. The brain is protected by the blood-brain barrier (BBB) that allows selective traffic of substances into the brain. Fluoride is a highly toxic and reactive element. We get exposed to fluoride due to its common use in toothpaste, dental gels, non-stick pans, razor blades, etc. Fluoride also enters our food chain through fishes that are cultivated in water bodies, which get contaminated with fluoride from running water from farms around it. Fluoride can accumulate on our body and cause toxic effects. In the context of fluoride, it is reported that fluoride exposure causes various toxic effects in our body, including the central nervous system as well. Fluoride is known to cross the blood-brain barrier and enter our brain tissue. It interferes with the normal metabolic process of the brain, generates free radicals and causes various toxic effects therein. Fluoride has been found to be linked to various pathogenic conditions of the brain as well. In this...
Read More
