Posted by admin on Nov 30, 2019 in |
This paper is to review the green catalytic synthesis of organic reactions and discussed its advantages over the conventional method of synthesis. Recent advanced technologies have key trend to reduce the negative impacts of chemical environment and helps to obtain sustainability in chemical production. This review tries to bring many catalytic techniques that are safer in nature and more economical. We have considered those synthetic schemes which have significant role in pharmaceuticals industry and the different green catalyst employed in those reactions. These organic reactions have special advantages with the use of catalyst; there is better utilization of starting materials and minimum waste product formation. The main objective of these synthetic schemes is that there is least pollution to the...
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Posted by admin on Nov 30, 2019 in |
Antibiotic is the powerful invention of science to damage bacterial infections. But nowadays, the use of careless increasing doses of this antibiotic has led to increasing the resistant power of enemy bacteria. Bacteria are caused by many infectious diseases by proliferation within quorum sensing (QS) mediated biofilms. Quorum sensing can develop microbial pathogenic traits, including biofilm formation. Try to smash biofilms have led the identification of bioactive molecules evolved by prokaryotes and eukaryotes. The activity of these bioactive molecules is done by quenching the QS systems. For this reason, we need to inhibit quorum sensing, which may be done by various types of inhibitors called quorum sensing inhibitors (QSI). Synthetic and natural QSIs plays a vital role to inhibit QS. In this review, some examples of QS inhibitors like synthetic and natural based QS inhibitors are highlighted. This review is also focused on the inhibition of QS mechanisms and the application of QSI in various...
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Posted by admin on Nov 30, 2019 in |
Schizophrenia is a chronic and severe mental disorder that affects how a person thinks, feels, and behaves. People with schizophrenia may seem like they have lost touch with reality. Schizophrenia is a split personality disorder which is related to mental illness. Generally, schizophrenia affects approximately 1 percent of all adults’ population. Schizophrenia is different types such as paranoid in which auditory hallucinations occur, some time disorganized schizophrenia occurs in which disorganized speech and behavior are shown. The hypothesis of schizophrenia included dopamine hypothesis, glutamatergic hypothesis, GABAergic hypothesis. Pharmacologically, they are characterized as dopamine receptor antagonists, though many of them also act on other targets, particularly 5-hydroxytryptamine (5-HT) receptors. The antipsychotic agents are used for the treatment of schizophrenia. Based on pharmacologic action, the chemical structures of antipsychotic agents contain reserpine- like compounds, phenothiazines derivatives and compounds include various tricyclic derivatives with a central 7-membered ring to which methyl piperazine is linked. The activity of this group is widely scattered, containing among the weakest and more potent of the apomorphine...
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Posted by admin on Nov 30, 2019 in |
Inflammation is the vascular event shown by the body against the external material by activating different cells and releasing various chemical mediators to prevent noxious effects. Many drugs like steroidal and non-steroidal drugs are available till the date to treat inflammation but have a number of side effects and centralized on to counteract the COX and LOX pathways. This perspective will use to search for new drugs that can work to target other pro-inflammatory mediators involve in inflammation and act as target for the inhibition of inflammatory processes and minimize the side effects. The therapeutic targets are any proteins, receptors, pro-inflammatory mediators or enzymes that can be involved in the inflammatory reaction. The targeted therapy acts on it and inhibits targets to combat the inflammation. The recent study assembles the data on novel targets and future anti-inflammatory drugs and the best treatment for incurable inflammatory...
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Posted by admin on Nov 30, 2019 in |
The skin is the largest organ of the human body and easily accessible. It’s potential as an alternative route for administering drugs for both systemic and local effects has attracted considerable interest. Most of the topical medications which are applied on the skin or mucous membrane to treat ailments include a wide range of creams, foams, gels, lotions, ointments, eye drops, ear drops, etc. Topical drug delivery provides a convenient and effective system for the treatment of local pathological conditions (dermal drug delivery) or as the site for systemic drug administration (transdermal drug delivery). Nanostructured Lipid Carriers (NLCs) are drug-delivery systems composed of both solid and liquid lipids as a core matrix. It has been shown that NLCs exhibit several advantages for drug therapy over conventional carriers including increased solubility and stability, improved permeability and bioavailability, reduced adverse effects, prolonged half-life, and tissue-targeted delivery. NLCs have attracted expanding scientific and commercial vigilance in the last couple of years as alternate carriers for the pharmaceuticals. A new generation of NLCs...
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